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11.
Liang X Parkinson JA Weishäupl M Gould RO Paisey SJ Park HS Hunter TM Blindauer CA Parsons S Sadler PJ 《Journal of the American Chemical Society》2002,124(31):9105-9112
As platforms for the design of metal-based therapeutic and diagnostic agents, macrocycles are rigid enough to provide strong metal binding sites and orient functional groups stereoselectively, yet flexible enough to accommodate structural changes required for induced-fit recognition of biological targets. We consider the recognition of the Zn(II) complex of the bis-tetraazamacrocycle xylyl-bicyclam, a potent anti-HIV agent, by the coreceptor CXCR4, a G-protein-coupled receptor used by HIV for membrane fusion and cell entry. NMR studies show that the macrocycles of Zn(II)(2)-xylyl-bicyclam perchlorate exist in aqueous solution as two major configurations, trans-I (nitrogen chirality R,S,R,S), and trans-III (S,S,R,R). Acetate addition induced a major structural change. X-ray crystallography shows that the acetate complex contains the unusual cis-V cyclam configuration (R,R,R,R and folded) with bidentate coordination of acetate to Zn(II) plus second-coordination-sphere double H-bond formation between diagonal NH protons on the opposite cyclam face and acetate carboxylate oxygens. Detailed 1D and 2D NMR studies show that the major configuration of Zn(II)(2)-xylyl-bicyclam acetate in aqueous solution is cis-V/trans-I. Molecular modeling shows that an analogous cis-V site can be formed when Zn(II)(2)-xylyl-bicyclam binds to CXCR4, involving the carboxylate groups of Asp262 (Zn(II) coordination) and Glu288 (double H-bonding). The second cyclam can adopt the trans-I (or trans-III) configuration with Zn(II) binding to Asp171. These interactions are consistent with the known structure-activity relationships for bicyclam anti-HIV activity and receptor mutation. Consideration of the anti-HIV activity of xylyl-bicyclam complexes of other metal ions suggests that affinity for carboxylates, configurational flexibility, and kinetic factors may all play roles in receptor recognition. For example, Pd(II) cyclam complexes interact only weakly with axial ligands and are inflexible and inactive, whereas Co(III) cyclams bind carboxylates strongly, are configurationally flexible, and yet have low activity. Our findings should aid the design of new generations of active macrocycles including highly specific chemokine receptor antagonists. 相似文献
12.
Compared to Pt or Pd electrodes, Au is a poor catalyst for the direct anodic oxidation of HCOOH, but the formation of Au surface oxides in acidic solutions is accompanied by a fast oxidation of HCOOH. This fast reaction is not simply a secondary reaction of Au surface oxides since those oxides are kinetically stable in HCOOH solutions. They do oxidize HCOOH only via a slow and purely electrochemical process which occurs on free Au sites and is “driven” by oxide reduction. The fast HCOOH oxidation is due to a highly reactive intermediate which is able either to form stable Au oxides AunOm or to react with HCOOH. Our results are consistent with the model that by the charge transfer step a reactive non-equilibrium {Au…O> species is formed which converts to stable equilibrium oxides AunOm after migration and rearrangement steps. Pre-equilibrium <Au…O> oxidizes HCOOH and this oxidation is of lower order with respect to <Au…O> compared with the formation of AunOm. 相似文献
13.
Bao J Baker RK Doss GA Kayser F Kotliar A Miao S Parsons WH Rupprecht KM 《Organic letters》2002,4(11):1871-1873
[reaction: see text] Pentacyclic triterpenoid natural product correolide (1) was converted to ketone 2 via ozonolysis. An unusual fragmentation reaction of ketone 2 with LiCl was discovered. This reaction is general among several similar substrates examined and appears to be specific for the correolide-type E-ring structure (ketone). A mechanism involving a retroaldol reaction, a nucleophilic opening of the epoxide, and a subsequent acetoxy elimination reaction was proposed. 相似文献
14.
Govers HA Krop HB Parsons JR Tambach T Kubicki JD 《SAR and QSAR in environmental research》2002,13(2):271-280
Enthalpies of transfer at 300 K of various partitioning processes were calculated in order to study the suitability of 3D force fields for the calculation of partitioning constants. A 3D fulvic acid (FA) model of dissolved organic carbon (DOC) was built in a MM+ force field using AMI atomic charges and geometrical optimization (GO). 3,5-Dichlorobiphenyl (PCB14), 4,4'-dichlorobiphenyl (PCB15), 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)-ethane (PPDDT) and 2-chloro-4-ethylamino-6-isopropylamino-s-triazine (Atrazine) were inserted into different sites and their interaction energies with FA were calculated. Energies of hydration were calculated and subtracted from FA-contaminant interactions of selected sites. The resulting values for the enthalpies of transfer from water to DOC were 2.8, -1.4, -6.4 and 0.0 kcal/mol for PCB 14, PCB15, PPDDT and Atrazine, respectively. The value of PPDDT compared favorably with the experimental value of -5.0 kcal/mol. Prior to this, the method was studied by the calculation of the enthalpies of vaporization and aqueous solution using various force fields. In the MM + force field GO predicted enthalpies of vaporization deviated by +0.7 (PCB14), +3.6 (PCB15) and -0.7 (PPDDT)kcal/mol from experimental data, whereas enthalpies of aqueous solution deviated by -3.6 (PCB14), +5.8 (PCB15) and +3.7 (PPDDT) kcal/mol. Only for PCB14 the wrong sign of this enthalpy value was predicted. Potential advantages and limitations of the approach were discussed. 相似文献
15.
H. Bao S. Navaratnam B. J. Parsons G. O. Phillips 《Radiation Physics and Chemistry》1993,42(4-6):989-992
One-electron oxidation of the ferrous tris-PQ complex, a model for lipoxygenase, was attempted using oxidants such as •OH, N•3, Br•-2, Tl2+ and TlOH+. •OH was found to react with the complex with a bimolecular rate constant of (3.9±0.6)x109dm3mol-1s-1, a rate which is not very dissimilar to that for the reaction with the ligand PQ. However the product of the reaction was found to be a OH-adduct rather than a cation radical. No reaction was found to occur with N•3 or Br•-2. Both Tl2+ and TlOH+ reacted with the complex to form its oxidised species with rate constants of (7.0±1)x108dm3mol-1s-1 and (4.0±0.8)x108dm3mol-1s-1, respectively. From a comparison of the rate constants and the transient spectra it was concluded that the centre of oxidation is the ligand rather than the metal. 相似文献
16.
Frey M Harris SG Holmes JM Nation DA Parsons S Tasker PA Winpenny RE 《Chemistry (Weinheim an der Bergstrasse, Germany)》2000,6(8):1407-1415
Two polymetallic iron(III) complexes 1 and 2 have been synthesised from the known corrosion inhibitor 3-(4-methylbenzoyl)-propionic acid HL1 and their crystal structures determined. Coordination geometries extracted from these structures have been used as the basis for molecular modelling onto idealised iron(III) oxide surfaces as an aid to understanding the efficacy of inhibitors of the 4-keto acid type. The proposed mode of action involves 1,3-bridging didentate coordination of the carboxylate function of L1 to two FeIII ions, hydrogen-bond formation between the 4-keto group of L1 and a bridging surface hydroxy group, as well as close packing of the aromatic end groups, which should generate a hydrophobic barrier on the surface. Adsorption isotherm experiments have been used to compare the strengths of binding of related carboxylic acids onto iron(III) oxide surfaces and indicate that the presence of the 4-keto function leads to the formation of significantly more stable surface complexes. 相似文献
17.
18.
Akiba Y Beavis D Beery P Britt HC Budick B Chasman C Chen Z Chi CY Chu YY Cianciolo V Cole BA Costales JB Crawford HJ Cumming JB Debbe R Engelage J Fung SY Gonin M Gushue S Hamagaki H Hansen O Hayano RS Hayashi S Homma S Kaneko H Kang J Kaufman S Kehoe WL Kurita K Ledoux RJ Levine MJ Miake Y Morrison DP Morse RJ Moskowitz B Nagamiya S Namboodiri MN Nayak TK Olness J Parsons CG Remsberg LP Roehrich D Rothschild P Sakurai H Sangster TC Seto R Soltz R Stankus P Steadman SG Stephans GS Sung T 《Physical review letters》1996,76(12):2021-2024
19.
20.
R. N. Haward J. N. Hay I. W. Parsons G. Adam A. A. K. Owadh C. P. Boxnyak A. Aref-Azaf A. Cross 《Colloid and polymer science》1980,258(6):643-662
Summary In a tensile test ductile thermoplastics may give either uniform deformation or necking. Recently it has been found that those giving uniform deformation either, are known to have extended chain configurations in solution, or have chemical formulae with linear structures and relatively few flexible bonds. The observed differences in behaviour can be predicted from a viscosity retarded rubber elasticity model in which a constant related to chain flexibility is introduced, which quantifies the strain hardening of the material. It is argued that the early development of strain hardening generally interferes with the localization of plastic strain in shear bands or crazes (as well as in a neck) and correlates with the stress cracking performance of high density polythenes.There is now also some evidence that polymers with extended chain configurations have small values ofcp (the change in specific heat atTg) and that this figure has an apparent correlation with draw ratio for different polymers.In the case of P.V.C. however it is possible to cause a changeover from the normal necking behaviour to uniform deformation by quenching the hot material in ice water. This process is believed to eliminate a structure which develops slowly in P.V.C. and most other thermoplastics when they are annealed at temperatures near toTg. The elimination of this structure during yielding causes strain softening and also promotes plastic strain localisation.This physical ageing or annealing process is still not well understood. It almost certainly includes free volume effects but recent studies have shown that a redistribution of rotational isomers also occurs. These observation, if correct, have fundamental implications for the physics of glassy polymers.
Dedicated to Prof. Dr. Rehage on the occasion of his 60th birthday.
With 22 figures and 2 tables 相似文献
Zusammenfassung Beim Zug-Test erfolgt bei dehnbaren Thermoplasten entweder eine gleichmäßige Deformation oder eine Einschnürung. Erstere tritt auf bei Vorliegen ausgestreckter Kettenkonfigurationen in Lösung oder bei Makromolekülen linearer Struktur und relativ unbiegsamer Bindungen. Die beobachteten Unterschiede wurden anhand eines ViskositätsModells mit verminderter Gummi-Elastizität unter Zugrundelegung von Literaturdaten diskutiert. Die Kettensteifheit wird rechnerisch durch Einfügung einer Konstanten berücksichtigt; sie steht in Konkurrenz mit der Lokalisierung der plastischen Dehnung und korreliert mit dem Auftreten einer Spannungsriß-Bildung im Polyäthylen hoher Dichte. Es wird darauf hingewiesen, daß sich die spezifische Wärme von Polymeren mit ausgedehnter Kettenkonfiguration beiTg nur wenig ändert; dieser Effekt steht mit dem Dehnungsverhältnis verschiedener Polymerer in Einklang.Bei PVC kann jedoch durch Abschrecken des heißen Materials in Eiswasser ein Übergang vom normalen Einschnürungsverhalten zu einer gleichmäßigen Deformation erzielt werden; dieser Effekt ist durch die Unterdrückung einer speziellen Struktur bedingt und kann auch bei der Temperung anderer thermoplastischer Polymerer nahe beiTg auftreten.Die sich bei der physikalischen Alterung und bei der Temperung abspielenden Vorgänge lassen sich noch nicht erklären. Sie umfassen sicherlich Effekte des freien Volumens und die Rückverteilung von Rotations-Isomeren. Beobachtungen dieser Art sind von grundsätzlicher Bedeutung für die Physik glasartiger Polymerer.
Dedicated to Prof. Dr. Rehage on the occasion of his 60th birthday.
With 22 figures and 2 tables 相似文献