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441.
442.
The effect of the saturability of noncovalent interactions on the character of opioid activity of opioid receptor ligands belonging to different structural classes was investigated. A three-dimensional model for an opiate pharmacophore was used to show that the involvement of pharmacophore elements, which are responsible for the agonist ligand binding to opioid receptors, in intramolecular interactions gives rise to antagonistic properties. 相似文献
443.
The cleavage of a set of phosphate mono-, di-, and triesters having a Cu(II)-complexed 2-phenanthrolyl group at the ortho-position of a departing phenoxide was studied in water and ethanol. Experimentally observed pH/rate profiles, solvent deuterium kinetic isotope effects, and activation parameters are compared with those obtained in methanol. The pH/rate profile in each solvent exhibits an extended plateau due to solvent attack on forms designated as [Cu(II):1b/c](0) for the monoester, [Cu(II):2b](+), for the diester, and [Cu(II):3a](2+) for the triester. The solvent dkie values (k(H)/k(D)) for the three complexes are 0.91, 0.95, and 0.83 for decomposition of [Cu(II):1b/c](0) in water (W), methanol (M), and ethanol (E), 1.22, 1.09, and 1.29 for [Cu(II):2b](+) in W, M, and E, and 1.94, 2.2, and 1.96 for [Cu(II):3a](2+) in W, M, and E. Near unit, or slightly inverse values for the monoester are taken as evidence for little involvement of solvent in a highly dissociative TS for P-OAr cleavage, with slightly higher solvent dkie values for the diester signifying the onset of some solvent participation in assisting the nucleophilic displacement. The larger primary dkie for the triester gives evidence for a solvent-assisted delivery of ROH in the cleavage through a more associative mechanism. Activation parameters for each substrate in the solvents are compared, indicating that the transition from methanol to ethanol for each substrate involves a near cancellation of the ΔΔH(?) and -TΔΔS(?) values (25 °C) so that the respective rates in both solvents are very similar. The transition from alcohol to water produces variable effects, with ΔΔH(?) and -TΔΔS(?) values canceling for cleavage of the triester and being additive for the mono and diester, explaining their 100-500 rate reduction in passing from methanol to water. The rate enhancing effects of the Cu(II)-promoted leaving group assistance in all three solvents are substantial and estimated at 10(12)-10(15) for the monoester, 10(12)-10(14) for the diester, and 10(5) for the triester relative to their background reactions. 相似文献
444.
Stan Gudder 《Mathematica Slovaca》2012,62(6):1209-1230
We show that any decoherence functional D can be represented by a spanning vector-valued measure on a complex Hilbert space. Moreover, this representation is unique up to an isomorphism when the system is finite. We consider the natural map U from the history Hilbert space K to the standard Hilbert space H of the usual quantum formulation. We show that U is an isomorphism from K onto a closed subspace of H and that U is an isomorphism from K onto H if and only if the representation is spanning. We then apply this work to show that a quantum measure has a Hilbert space representation if and only if it is strongly positive. We also discuss classical decoherence functionals, operator-valued measures and quantum operator measures. 相似文献
445.
We consider the non‐local singular boundary value problem (1) where q ∈ C0([0,1]) and f, h ∈ C0((0,∞)), limf(x)=?∞, limh(x)=∞. We present conditions guaranteeing the existence of a solution x ∈ C1([0,1]) ∩ C2((0,1]) which is positive on (0,1]. The proof of the existence result is based on regularization and sequential techniques and on a non‐linear alternative of Leray–Schauder type. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
446.
We consider non-negative solutions of the semilinear elliptic equation in Rn with n?3:
−Δu=a(x)uq+b(x)up, 相似文献
447.
Christopher I. Maxwell C. Tony Liu Alexei A. Neverov Nicholas J. Mosey Robert Stan Brown 《Journal of Physical Organic Chemistry》2012,25(5):437-449
The base‐promoted solvolysis of a series of O,O‐dimethyl O‐aryl and O,O‐dimethyl O‐alkyl phosphorothioates (1) as well as O,O‐dimethyl O‐aryl and O,O‐dimethyl O‐alkyl phosphates (2) was studied computationally by density functional theory methods in methanol and water continuum media to determine the transition between concerted and stepwise processes. In addition, an experimental study was undertaken on the solvolysis of these series in basic methanol and water. The computations indicate that the solvolytic mechanism for series 1 involves lyoxide attack anti to the leaving group in a concerted manner with good leaving groups having pKaLg values < 12.3 in methanol and in a stepwise fashion with the formation of a 5‐coordinate thiophosphorane intermediate when the pKaLg > 12.3. A similar transition from concerted to stepwise mechanism occurs with series 2 in methanol as well as with series 1 and 2 in water, although for the aqueous solvolyses with hydroxide nucleophile, the transitions between concerted and stepwise mechanisms occur with better leaving groups than in the case in methanol. The computational data allow the construction of Brønsted plots of log k2?OS versus pKaLg in methanol and water, which are compared with the experimental Brønsted plots determined with these series previously and with new data determined in this work. Both the computational and experimental Brønsted data reveal discontinuities in the plots between substrates bearing O‐aryl and O‐alkyl leaving groups, with the gradients of the plots being far steeper than, and non‐collinear with, the O‐aryl leaving groups for solvolysis of the O‐alkyl‐containing substrates. These discontinuities signify that care should be exercised in interpreting breaks in Brønsted plots in terms of changes in rate‐limiting steps that signify the formation of an intermediate during a solvolytic process. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
448.
This paper is aimed at presenting a study on the optimization of the Biglide mini parallel robot, which comprises two-degree-of-freedom (DOF) mini parallel robots with constant struts. The robot workspace is characterized and the inverse kinematics equation is obtained. In the paper, design optimization is implemented with Genetic Algorithms (GA) for optimization considering transmission quality index and workspace. Here, intended to show the advantages of using the GA, we applied it to a multicriteria optimization problem of 2 DOF mini parallel robot. Genetic algorithms (GA) are so far generally the best and most robust kind of evolutionary algorithms. A GA has a number of advantages. It can quickly scan a vast solution set. Bad proposals do not affect the end solution negatively as they are simply discarded. The obtained results have shown that the use of GA in such kind of optimization problem enhances the quality of the optimization outcome, providing a better and more realistic support for the decision maker. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献