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171.
This article reviews recent developments in the application of capillary electrophoresis (CE) for the analysis of foods and food components. CE has been applied to a number of important areas of food analysis and is fast becoming an established technique within food analytical and research laboratories. Papers are reviewed that were published during the two years to date following the previous review (Electrophoresis 2001, 22, 4197-4206). 相似文献
172.
Alagona G Ghio C Iuliano A Monti S Pieraccini I Salvadori P 《The Journal of organic chemistry》2003,68(8):3145-3157
CD spectra of the chiral auxiliaries for enantioselective HPLC N-allyl-N'-methyl-3,12-bis(2-naphthyl)carbamoyloxy-7-(3,5-dinitrophenyl)carbamoyloxycholan-24-amide (1), N-allyl-N'-methyl-3-(3,5-dinitrophenyl)carbamoyloxy-7,12-bis(2-naphthyl)carbamoyloxycholan-24-amide (2), N-allyl-N'-methyl-3,7-bis(2-naphthyl)carbamoyloxy-12-(3,5-dinitrophenyl)carbamoyloxycholan-24-amide (3), and N-allyl-N'-methyl-3,7,12-tris(2-naphthyl)carbamoyloxycholan-24-amide (4) are presented. To determine the preferred conformations of those chiral auxiliaries, a random search based on the aromatic side-chain conformational degrees of freedom was performed and the energy was minimized using two different molecular mechanics force fields. The low energy structures presenting common features were arranged in groups and selected exploiting appropriate filters. The calculation of theoretical CD spectra according to the De Voe model has allowed a further discrimination among the conformations, specifying which of them gave calculated CD spectra in acceptable agreement with the experimental ones. Finally, taking into account the additivity of the contributions of each 2-naphthylcarbamate chromophore to the CD spectrum of the cholic acid derivatives, and, hence, choosing, for derivatives 1-3, those conformations in which the 2-naphthylcarbamate groups take a similar disposition as in 4, the preferentially assumed conformation of each compound was obtained. A molecular dynamics simulation in the presence of acetonitrile allowed the fluctuations of one of the structures, used as a test case, depending on environmental effects, to be examined. 相似文献
173.
Maria V. Papadopoulou Shyamaprosad Goswami Andrew D. Hamilton 《Journal of heterocyclic chemistry》1995,32(2):675-681
Open chain podands 2a-c and macrocycles 2d-e have been synthesized as potential candidates for 4-aminopterin recognition and binding, featuring H? bonding characteristics and “stacking interaction” 2e. Preliminary binding studies between 6, 7 , and 8 (simpler analogs of the above 2a-e ) as “bosts” and appropriate “guests”, showed that carbamates 2a and 2e are the most promising receptors for 4-aminopterin binding. 相似文献
174.
The solvation of gallic acid (in water and acetonitrile) is studied by means of its spectroscopic properties. IR, UV, and NMR spectra are predicted by using various solvation models obtained in terms of both purely classical and density functional approaches. Comparison with experiments is used to validate solvation models. Hydrogen-bond and long-range (or bulk) effects are evaluated by comparing different solvation models. A continuum-only approach, a purely discrete, and a mixed continuum/discrete approach based on quantum-mechanical and classical molecular-dynamics solute-solvent clusters are tested. 相似文献
175.
Fernández-Carneado J Van Gool M Martos V Castel S Prados P de Mendoza J Giralt E 《Journal of the American Chemical Society》2005,127(3):869-874
Oligoguanidinium-based cell delivery systems have gained broad interest in the drug delivery field since one decade ago. Thus, arginine-containing peptides as Tat or Antp, oligoarginine peptides, and derived peptoids have been described as shuttles for delivering nonpermeant drugs inside cancer cells. Herein we report a new family of tetraguanidinium cell penetrating vectors efficiently internalized in human tumor cells. Their high internalization, studied by confocal microscopy and flow cytometry, as well as their specific accumulation in mitochondria makes these new vectors likely vehicles for the targeted delivery of anticancer drugs to mitochondria. 相似文献
176.
Bernd Wrackmeyer Susanna Kerschl Heide E. Maisel Wolgang Milius 《Journal of organometallic chemistry》1995,490(1-2):197-202
(E)-2-Chlorodimethylstannyl-3-diethylboryl-2-pentene (1) reacts with the C-lithiated azoles 2 (derived from thiazole (2a), 4-methylthiazole (2b), 1,4-dimethylimidazole (2c), benzoxazole (2d) and benzthiazole (2e)) to eliminate LiCl, giving first mixtures containing compounds with either a coordinative N--- bond (3) or the zwitterionic isomer with an Sn---N bond (4), or both, and in some cases a rearranged product (5) with a 1,2,5-azastannaborole unit is also present. The zwitterionic compounds 4 tend to rearrange into the heterocycles 5 in which the heteroaromatic system is no longer present and two new C---C bonds, a new B---C and a new B---N bond are formed. The reactions were monitored by multinuclear NMR (1H, 11B, 13C, 14N and 119Sn NMR) which also served for the characterization of the final products. In the case of 5e, the molecular structure was determined by single-crystal X-ray analysis (monoclinic; space group P21/n; A=11.691(2), B=12.396(2), C=13.149(2) Å; β=93.41(2)°). 相似文献
177.
Farrera-Sinfreu J Giralt E Castel S Albericio F Royo M 《Journal of the American Chemical Society》2005,127(26):9459-9468
The synthesis of cis-gamma-amino-l-proline oligomers functionalized at the proline alpha-amine with several groups that mimic the side chains of natural amino acids, including alanine, leucine, and phenylalanine, is herein described. These gamma-peptides enter into different cell lines (COS-1 and HeLa) via an endocytic mechanism. The ability of these compounds to be taken up into cells was studied at 37 degrees C and 4 degrees C by plate fluorimetry, flow cytometry, and confocal microscopy. In addition to their capacity for cellular uptake, these unnatural short length oligomers offer advantages over the well-known penetrating TAT peptide, such as being less toxic than TAT and protease resistance. 相似文献
178.
This paper presents a novel method to embed, anchor, and cultivate cells in a controlled 3-D flow-through microenvironment. This is realized using an etched silicon pillar flow chamber filled with extracellular matrix (ECM) gel mixed with cells. At 4 degrees C, while in liquid form, ECM gel is mixed with cells and injected into the chamber. Raising the temperature to 37 degrees C results in a gel, with cells embedded. The silicon pillars both stabilize and increase the surface to volume ratio of the gel. During polymerization the gel shrinks, thus creating channels, which enables perfusion through the chip. The pillars increase the mechanical stability of the gel permitting high surface flow rates without surface modifications. Within the structure cells were still viable and proliferating after 6 days of cultivation. Our method thus makes it possible to perform medium- to long-term cultivation of cells in a controlled 3-D environment. This concept opens possibilities to perform studies of cells in a more physiological environment compared to traditional 2-D cultures on flat substrates. 相似文献
179.
Jared N. King Vanessa J. Lee Dr. Susanna Ahola Dr. Ville‐Veikko Telkki Prof. Dr. Tyler Meldrum 《Angewandte Chemie (International ed. in English)》2016,55(16):5040-5043
Laplace NMR (LNMR) consists of relaxation and diffusion measurements providing detailed information about molecular motion and interaction. Here we demonstrate that ultrafast single‐ and multidimensional LNMR experiments, based on spatial encoding, are viable with low‐field, single‐sided magnets with an inhomogeneous magnetic field. This approach shortens the experiment time by one to two orders of magnitude relative to traditional experiments, and increases the sensitivity per unit time by a factor of three. The reduction of time required to collect multidimensional data opens significant prospects for mobile chemical analysis using NMR. Particularly tantalizing is future use of hyperpolarization to increase sensitivity by orders of magnitude, allowed by single‐scan approach. 相似文献
180.
A simple synthesis of a polyaromatic receptor (i.e., duplexiphane) containing two adjoined Delta-shaped cavities is accomplished via an intramolecular (double) McMurry coupling, and its structure is established by X-ray crystallography. The binding of silver cation to duplexiphane showed that it binds only a single silver cation with significantly higher efficiency (>100 times) than a model compound containing only one pi-prismand-like cavity, and the single silver cation hops intramolecularly between the two adjoined cavities in duplexiphane. 相似文献