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991.
Samy Cecioni Ruth Lalor Dr. Bertrand Blanchard Jean‐Pierre Praly Dr. Anne Imberty Dr. Susan E. Matthews Dr. Sébastien Vidal Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(47):13232-13240
A family of seven topologically isomeric calix[4]arene glycoconjugates was prepared through the synthesis of a series of alkyne‐derivatised calix[4]arene precursors that are suitable for the attachment of sugar moieties by microwave‐assisted copper(I)‐catalysed azide–alkyne cycloaddition (CuAAC). The glycoconjugates thus synthesised comprised one mono‐functionalised derivative, two 1,2‐ or 1,3‐divalent regioisomers, one trivalent and three tetravalent topoisomers in the cone, partial cone or 1,3‐alternate conformations. The designed glycoconjugates were evaluated as ligands for the galactose‐binding lectin PA‐IL from the opportunistic bacterium Pseudomonas aeruginosa, a major causative agent of lung infections in cystic fibrosis patients. Binding affinities were determined by isothermal titration calorimetry (ITC), and the interaction with the lectin was shown to be strongly dependant on both the valence and the topology. Whereas the trivalent conjugate displayed enhanced affinity when compared to a monosaccharide model, the tetravalent conjugates are to‐date the highest‐affinity ligands measured by ITC. The topologies presenting carbohydrates on both faces of calixarene are the most potent ones with dissociation constants of approximately 200 nM . Molecular modelling suggests that such a multivalent molecule can efficiently chelate two of the binding sites of the tetrameric lectin; this explains the 800‐fold increase of affinity achieved by the tetravalent molecule. Surface plasmon resonance (SPR) experiments confirmed that this glycoconjugate is the strongest inhibitor for binding of PA‐IL to galactosylated surfaces for potential applications as an anti‐adhesive agent. 相似文献
992.
Replacement of calcium with europium in the phases Ca21Ni2Zn36 and CaNi2Zn3 was attempted to explore the possibility of substitution in metal flux reactions and potential magnetic interactions between closely spaced Eu2+ ions. Limited substitution occurs when Eu is added to the reaction of nickel in a Ca/Zn flux mixture, up to stoichiometries of Eu5.8(3)Ca15.2(3)Ni2Zn36 and Eu0.42(8)Ca0.58(8)Ni2Zn3. Structural characterization and magnetic susceptibility studies on EuxCa21−xNi2Zn36 phases indicate that the Eu and Ca ions do not form an even solid solution on their sites, but instead segregate in separate regions of the crystals. The europium-rich regions of the samples order ferromagnetically, with TC dependent on the size of the clusters. If the concentration of Eu in the flux is raised above 20 mol%, a new compound Eu1.63(1)Ca1.37(1)Ni2Zn3 (Cmcm, a=4.1150(5) Å, b=16.948(2) Å, c=10.302(1) Å, Z=4, R1=0.0396) is produced. 相似文献
993.
994.
David Crisp Susan Dziadosz Dennis J. Garity Thomas Insel Thomas A. Schmidt Peter Wiles 《Monatshefte für Mathematik》1998,125(3):189-209
We classify the free homotopy classes of closed curves with minimal self intersection number two on a once punctured torus,T, up to homeomorphism. Of these, there are six primitive classes and two imprimitive. The classification leads to the topological result that, up to homeomorphism, there is a unique curve in each class realizing the minimum self intersection number. The classification yields a complete classification of geodesics on hyperbolicT which have self intersection number two. We also derive new results on the Markoff spectrum of diophantine approximation; in particular, exactly three of the imprimitive classes correspond to families of Markoff values below Hall's ray.Research started during the Summer 1994 NSF REU Program at Oregon State University and partially supported by NSF DMS 9300281 相似文献
995.
996.
997.
Susan L. Bontems Judith Stein Michael A. Zumbrum 《Journal of polymer science. Part A, Polymer chemistry》1993,31(11):2697-2710
α,ω-Divinyl-terminated polydimethylsiloxane polymers with low polydispersivity were synthesized via anionic polymerization of hexamethylcyclotrisiloxane (D3). Five “monodisperse” polymers with different molecular weights were hydrosilylated with tetrakisdimethylsiloxysilane in the presence of platinum catalysts and inhibitors to form crosslinked networks. Control studies to determine the effect of platinum, silicon hydride, and heat were performed to verify that no redistribution occurred during hydrosilylation. The properties of these cured samples were characterized chemically by degradation with trifluoromethanesulfonic acid in the presence of hexamethyldisiloxane, infrared spectroscopy, and nuclear magnetic spectroscopy. Mechanical properties were studied by measurements of Shore A hardness, dynamic shear modulus, and tensile modulus. The relationship between the molecular weight of the vinyl polymer and the final properties of the cured networks was measured. © 1993 John Wiley & Sons, Inc. 相似文献
998.
A simple, precise and rapid RP-HPLC method was developed for the determination of repaglinide in pharmaceutical dosage forms. The method was carried out on a Shim-pack, RP-C18 column using a mixture of methanol: 0.1% v/v triethylamine (pH adjusted to 7 with orthophosphoric acid) and detection was done at 235 nm using nimesulide as internal standard. The linearity range was 0.1 to 0.5 microg/ml. The intra-day and inter-day precision were in the range of 0.48 to 1.01 and 0.15 to 1.15, respectively. 相似文献
999.
Summary Screening new drugs is a costly and time-consuming process. Identifying new targets for existing therapeutics is often a particularly effective avenue for drug development. We have investigated whether in vitro selection can be used for target acquisition. Aminoglycoside antibiotics are known to bind to and inactivate functional natural nucleic acids, such as ribosomal RNA. As an example of how new targets for aminoglycosides could be identified, a lividomycin aptamer was iteratively isolated from a random sequence pool. The consensus sequence of this and other anti-aminoglycoside aptamers was used as the basis for a comprehensive search of natural sequence databases. Surprisingly, a high degree of similarity was found between aptamers and genomic sequences from a variety of organisms. While many of the similarities found are in regions of unknown or nonessential function, some of the sequences are found in critical genes in pathogenic organisms. 相似文献
1000.
I. Büttner V. Hamm A. Kn?chel R. Sen Gupta 《Fresenius' Journal of Analytical Chemistry》1993,346(4):446-452
Summary Since the mid-fifties the possibility of a causal relationship between deficient chromium and insulin metabolism and the manifestation of certain varieties of diabetes mellitus has been presumed. The determination of the chromium status under pathophysiological conditions may be helpful for the study of this problem. For these purposes an analytical procedure as reference system was developed which allows the determination of chromium in biological matrices down to the concentration of 0.03 ng/ml. It is based on NAA and is used in the framework of a commonly used procedure based on GF-AAS. For its application blood and urine samples are freeze-dried and irradiated. After wet digestion with HNO3 in a microwave combustion system chromium is separated for measurement from the matrix nuclides with the help of the ion-exchanger Cellex-P. The individual steps of the procedure were evaluated by means of tracer experiments.Dedicated to Professor Dr. V. Krivan on the occasion of his 60th birthday. 相似文献