全文获取类型
收费全文 | 308篇 |
免费 | 1篇 |
专业分类
化学 | 145篇 |
晶体学 | 1篇 |
力学 | 3篇 |
数学 | 53篇 |
物理学 | 107篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 2篇 |
2018年 | 4篇 |
2017年 | 3篇 |
2016年 | 7篇 |
2015年 | 4篇 |
2014年 | 5篇 |
2013年 | 16篇 |
2012年 | 13篇 |
2011年 | 13篇 |
2010年 | 16篇 |
2009年 | 7篇 |
2008年 | 27篇 |
2007年 | 14篇 |
2006年 | 20篇 |
2005年 | 13篇 |
2004年 | 13篇 |
2003年 | 8篇 |
2002年 | 5篇 |
2001年 | 4篇 |
2000年 | 5篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1996年 | 4篇 |
1995年 | 9篇 |
1994年 | 4篇 |
1993年 | 5篇 |
1992年 | 5篇 |
1991年 | 2篇 |
1990年 | 6篇 |
1989年 | 5篇 |
1988年 | 3篇 |
1987年 | 6篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1976年 | 2篇 |
1974年 | 3篇 |
1955年 | 3篇 |
1954年 | 3篇 |
1944年 | 4篇 |
1942年 | 3篇 |
1940年 | 1篇 |
1935年 | 2篇 |
1903年 | 1篇 |
排序方式: 共有309条查询结果,搜索用时 15 毫秒
111.
We explore the possibility of deforming Gell-Mann-Okubo (GMO) mass formula within the framework of a quantized enveloping
algebra. A small value of the deformation parameter is found to provide a good fit to the observed mass spectra of theπ, K andη mesons. 相似文献
112.
113.
Mukherjee A Lavery R Bagchi B Hynes JT 《Journal of the American Chemical Society》2008,130(30):9747-9755
Intercalation into DNA (insertion between a pair of base pairs) is a critical step in the function of many anticancer drugs. Despite its importance, a detailed mechanistic understanding of this process at the molecular level is lacking. We have constructed, using extensive atomistic computer simulations and umbrella sampling techniques, a free energy landscape for the intercalation of the anticancer drug daunomycin into a twelve base pair B-DNA. A similar free energy landscape has been constructed for a probable intermediate DNA minor groove-bound state. These allow a molecular level understanding of aspects of the thermodynamics, DNA structural changes, and kinetic pathways of the intercalation process. Key DNA structural changes involve opening the future intercalation site base pairs toward the minor groove (positive roll), followed by an increase in the rise, accompanied by hydrogen bonding changes of the minor groove waters. The calculated intercalation free energy change is -12.3 kcal/mol, in reasonable agreement with the experimental estimate -9.4 kcal/mol. The results point to a mechanism in which the drug first binds to the minor groove and then intercalates into the DNA in an activated process, which is found to be in general agreement with experimental kinetic results. 相似文献
114.
115.
Fluorescence probes have been used to estimate Kamlet-Taft solvatochromic parameters alpha and pi* representing hydrogen-bond donation ability and dipolarity/polarizability, respectively, of sodium dodecyl sulfate (SDS)-Triton X 100 (TX100) mixed aggregates with varying compositions. The hydrogen-bond donation ability of the mixed aggregate has been found to increase with SDS composition, whereas the dipolarity/polarizability parameter decreases. The relative contribution of electrostatic and steric effect toward the total free energy of micellization have been calculated for the mixture. The solvatochromic parameters alpha and pi* depend linearly on the total free energy of micellization, indicating a correlation between aggregational and solvatochromic properties. 相似文献
116.
117.
Vasudev PG Ananda K Chatterjee S Aravinda S Shamala N Balaram P 《Journal of the American Chemical Society》2007,129(13):4039-4048
The crystal structure of 12 peptides containing the conformationally constrained 1-(aminomethyl)cyclohexaneacetic acid, gabapentin (Gpn), are reported. In all the 39 Gpn residues conformationally characterized so far, the torsion angles about the Calpha-Cbeta and Cbeta-Cgamma bonds are restricted to the gauche conformation (+/-60 degrees ). The Gpn residue is constrained to adopt folded conformations resulting in the formation of intramolecularly hydrogen-bonded structures even in short peptides. The peptides Boc-Ac6c-Gpn-OMe 1 and Boc-Gpn-Aib-Gpn-Aib-OMe 2 provide examples of C7 conformation; peptides Boc-Gpn-Aib-OH 3, Boc-Ac6c-Gpn-OH 4, Boc-Val-Pro-Gpn-OH 5, Piv-Pro-Gpn-Val-OMe 6, and Boc-Gpn-Gpn-Leu-OMe 7 provide examples of C9 conformation; peptide Boc-Ala-Aib-Gpn-Aib-Ala-OMe 8 provides an example of C12 conformation and peptides Boc-betaLeu-Gpn-Val-OMe 9 and Boc-betaPhe-Gpn-Phe-OMe 10 provide examples of C13 conformation. Gpn peptides provide examples of backbone expanded mimetics for canonical alpha-peptide turns like the gamma (C7) and the beta (C10) turns. The hybrid betagamma sequences provide an example of a mimetic of the C13 alpha-turn formed by three contiguous alpha-amino acid residues. Two examples of folded tripeptide structures, Boc-Gpn-betaPhe-Leu-OMe 11 and Boc-Aib-Gpn-betaPhg-NHMe 12, lacking internal hydrogen bonds are also presented. An analysis of available Gpn residue conformations provides the basis for future design of folded hybrid peptides. 相似文献
118.
119.
Layer-wise, distance-dependent orientational relaxation of water confined in reverse micelles (RM) is studied using theoretical and computational tools. We use both a newly constructed "spins on a ring" (SOR) Ising-type model (with Shore-Zwanzig rotational dynamics) and atomistic simulations with explicit water. Our study explores the effect of reverse micelle size and role of intermolecular correlations, compromised by the presence of a highly polar surface, on the distance (from the interface) dependence of water relaxation. The "spins on a ring" model can capture some aspects of distance dependence of relaxation, such as acceleration of orientational relaxation at intermediate layers. In atomistic simulations, layer-wise decomposition of hydrogen bond formation pattern clearly reveals that hydrogen bond arrangement of water at a certain distance away from the surface can remain frustrated due to the interaction with the polar surface head groups. This layer-wise analysis also reveals the presence of a non-monotonic slow relaxation component which can be attributed to this frustration effect and which is accentuated in small to intermediate size RMs. For large size RMs, the long time component decreases monotonically from the interface to the interior of the RMs with slowest relaxation observed at the interface. 相似文献
120.
Dielectric relaxation in orientationally disordered dipolar solids often exhibits exotic features, such as a strong Cole-Cole relaxation for simple molecular solids. However, there does not seem to exist a detailed molecular theory of such phenomena. In this article, a molecular hydrodynamic theory of dielectric relaxation in solid rotator phases, such as plastic crystals, is presented. 相似文献