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171.
Aleksandra Joniec Prof. Slawomir Sek Prof. Pawel Krysinski 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(49):17715-17724
Studies on magnetoliposomes (MLUV) as potential carriers for magnetic‐field‐dependent drug delivery are presented. The systems were formed with hydrophobic superparamagnetic iron oxide nanoparticles (SPIONs) confined within the bilayer of the liposomes. The nanomechanical properties of bilayer lipid membranes were evaluated and related to the amount of incorporated SPIONs. It was found that the presence of SPIONs in the lipid membrane leads to overall stiffening and increases morphological inhomogeneity, facilitating rupture of the MLUV membrane in a low‐frequency alternating magnetic field (AMF). To verify the findings, doxorubicin release from MLUVs in the presence and absence of an AMF was measured. Under experimental conditions, drug release proceeds through MLUV rupture induced by mechanical vibration of SPIONs rather than through localized heating in the vicinity of the SPIONs. 相似文献
172.
Regularity of solutions to a reaction–diffusion equation on the sphere: the Legendre series approach 下载免费PDF全文
Slawomir Bialecki Bogdan Kaźmierczak Dominika Nowicka Je‐Chiang Tsai 《Mathematical Methods in the Applied Sciences》2017,40(14):5349-5369
In the paper, we study some ‘a priori’ properties of mild solutions to a single reaction–diffusion equation with discontinuous nonlinear reaction term on the two‐dimensional sphere close to its poles. This equation is the counterpart of the well‐studied bistable reaction–diffusion equation on the Euclidean plane. The investigation of this equation on the sphere is mainly motivated by the phenomenon of the fertilization of oocytes or recent studies of wave propagation in a model of immune cells activation, in which the cell is modeled by a ball. Because of the discontinuous nature of reaction kinetics, the standard theory cannot guarantee the solution existence and its smoothness properties. Moreover, the singular nature of the diffusion operator near the north/south poles makes the analysis more involved. Unlike the case in the Euclidean plane, the (axially symmetric) Green's function for the heat operator on the sphere can only be represented by an infinite series of the Legendre polynomials. Our approach is to consider a formal series in Legendre polynomials obtained by assuming that the mild solution exists. We show that the solution to the equation subject to the Neumann boundary condition is C1 smooth in the spatial variable up to the north/south poles and Hölder continuous with respect to the time variable. Our results provide also a sort of ‘a priori’ estimates, which can be used in the existence proofs of mild solutions, for example, by means of the iterative methods. Copyright © 2017 John Wiley & Sons, Ltd. 相似文献
173.
Slawomir Podsiadlo Grzegorz Weisbrod Maciej Bialoglowski Daniel Jastrzebski Mohammad Fadaghi Andrzej Ostrowski 《ChemInform》2015,46(46):no-no
Single crystals of (NH4)2SnCl6 are obtained by thermal decomposition of SnCl4·5NH3 in the gas phase under a stream of gaseous NH3 (quartz tube, 298 °C, 6 h). 相似文献
174.
Dzierzega-Lecznar A Kurkiewicz S Stepien K Chodurek E Wilczok T Arzberger T Riederer P Gerlach M 《Journal of the American Society for Mass Spectrometry》2004,15(6):920-926
Neuromelanin (NM) is a complex polymer pigment found in catecholaminergic neurons of the human brain. The structure, formation pathway, and physiological function of NM have not yet been clarified, but interest in this polymer has been sparked by the suggestion that NM is involved in cell death in Parkinson's disease. In the current study, pyrolysis-gas chromatography/mass spectrometry analysis was applied for structural investigation of NM isolated from the human substantia nigra, using synthetic eumelanin and pheomelanin-type pigments as reference materials. None of the heterocyclic, sulfur-containing compounds being characteristic thermal degradation products of cysteinyldopamine-derived units of synthetic pheomelanin standard was detected in the pyrolysates of natural NM. The results suggest that nigral pigment isolated from normal brain tissue does not contain benzothiazine-type monomer units. Pyrolytic experiments in the presence of a derivatizing agent allowed identification of high levels of saturated and monounsaturated straight-chain C14-C18 fatty acids and led to the conclusion that a part of a lipid component is chemically bound to the NM macromolecule. The nigral pigment was also shown to be tightly associated with an isoprenoid-type compound. 相似文献
175.
Dr. Shuguang Yuan Dr. H. C. Stephen Chan Prof. Horst Vogel Prof. Slawomir Filipek Prof. Raymond C. Stevens Prof. Krzysztof Palczewski 《Angewandte Chemie (International ed. in English)》2016,55(35):10331-10335
Human purinergic G protein‐coupled receptor P2Y1 (P2Y1R) is activated by adenosine 5′‐diphosphate (ADP) to induce platelet activation and thereby serves as an important antithrombotic drug target. Crystal structures of P2Y1R revealed that one ligand (MRS2500) binds to the extracellular vestibule of this GPCR, whereas another (BPTU) occupies the surface between transmembrane (TM) helices TM2 and TM3. We introduced a total of 20 μs all‐atom long‐timescale molecular dynamic (MD) simulations to inquire why two molecules in completely different locations both serve as antagonists while ADP activates the receptor. Our results indicate that BPTU acts as an antagonist by stabilizing extracellular helix bundles leading to an increase of the lipid order, whereas MRS2500 blocks signaling by occupying the ligand binding site. Both antagonists stabilize an ionic lock within the receptor. However, binding of ADP breaks this ionic lock, forming a continuous water channel that leads to P2Y1R activation. 相似文献
176.
Groves P Kövér KE André S Bandorowicz-Pikula J Batta G Bruix M Buchet R Canales A Cañada FJ Gabius HJ Laurents DV Naranjo JR Palczewska M Pikula S Rial E Strzelecka-Kiliszek A Jiménez-Barbero J 《Magnetic resonance in chemistry : MRC》2007,45(9):745-748
We show that temperature is an important parameter for the sensitivity of saturation transfer difference (STD) spectroscopy. A decreased intensity of STD signals is observed for lactose binding to growth-regulatory galectin7 (p53-induced gene 1), as well as for nucleotide binding to annexin A6, when the temperature is increased from 281 to 298-310 K. Opposite temperature effects on STD intensity are observed for S-peptide binding to S-protein to reconstitute RNase S. However, the STD signals for tryptophan binding to downstream regulatory element antagonist modulator of the human prodynorphin gene (DREAM)are relatively unaffected between 281 and 298 K. The known kinetics of the binding of ATP by the uncoupling protein from brown adipose tissue mitochondria (UCP1) predicted an observable STD at 310 K, but rapid sample degradation limits the experiments to much lower temperatures. Temperature strongly influences the kinetics and affinity constant of various types of complex formation and in so doing influences the observed STD effects. Therefore, temperature can be exploited to facilitate the optimization of STD-based applications, and at the same time minimize the number of test samples. STD-based screening protocols to detect new target-specific compounds may yield a larger number of potential ligands if screened at various temperatures. 相似文献
177.
Kotulska M Kubica K Koronkiewicz S Kalinowski S 《Bioelectrochemistry (Amsterdam, Netherlands)》2007,70(1):64-70
Experiments show significant effects of an electric field on lipid membrane, leading to a pore formation when a high intensity field is applied. The phenomenon of electroporation is preceded by the induction and expansion of defects, responsible for the pre-pore excitation. We examine the mechanism of the induction of the field-driven defects by Monte Carlo simulations. The study is based on the improved Pink's model, which includes explicit interactions between the polar heads and energy of interactions between the heads and the field. No anomalous deformation of the molecules is considered. The study, provided for bilayer dipalmitoyl-phosphatidylcholine (DPPC) membrane in the gel (300 K) and fluid (330 K) phases, shows dependence of the membrane conformational and energetical state on the value of the electric field. We observe that the electric field affects the number of molecules in the gel and in the fluid states. In the layer at the negative potential, when the transmembrane voltage is above U(c) approximately 280 mV, lipid heads abruptly reorient and the number of local spots with fluid conformation increases. The other layer slightly tends to tighten its structure, producing additional mechanical stress between layers. Lipids showed complete insensitivity to the electric field within physiological limits, U<70 mV. 相似文献
178.
Iwan A Kaczmarczyk B Janeczek H Sek D Ostrowski S 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2007,66(4-5):1030-1041
Imines (ketimines and azomethines) derived from p-dibenzoylbenzene (DB) and terephthalic aldehyde (TA) and two aromatic amines: aniline and 2,6-dimethylaniline have been investigated. Compounds were synthesized via condensation of amines with carbonyl monomers in DMA or amine solution. When using DMA as a solvent, azomethines with high yields were obtained. On the other hand, the amines used as a monomers served also as an effective solvent for the synthesis of the ketanils. This different reactivity of the aldehyde and ketone groups in DMA and in amine depends on the dehydration mechanism being dominated by a kinetic process or thermodynamic one. On the basis of FTIR, 13C and 1H NMR, UV-vis spectra, thermal characteristic and theoretical calculations conclusions are drawn regarding the similarities and differences between azomethines and ketimines. 相似文献
179.
180.