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101.
102.
Cluster emission and chemical reactions in oxygen and nitrogen ices induced by fast heavy-ion impact
Ponciano CR Martinez R Farenzena LS Iza P Homem MG Naves de Brito A Wien K da Silveira EF 《Journal of mass spectrometry : JMS》2008,43(11):1521-1530
Two ices, O2 and a mixture of O2 and N2, are bombarded by 252Cf fission fragments (FF) (approximately 65 MeV at target surface); the emitted positive and negative secondary ions are analyzed by time-of-flight mass spectrometry (TOF-SIMS). These studies shall enlighten sputtering from planetary and interstellar ices. Three temperature regions in the 28-42-K range are analyzed: (1) before N2 sublimation, in which hybrid chemical species are formed, (2) before O2 sublimation, in which the TOF mass spectrum is dominated by low-mass (O2)p cluster ions and (3) after O2 sublimation, in which (N2)p or (O2)p cluster ions are practically inexistent. In the first region, four hybrid ion series are observed: NOn-1+, N2On-2(+/-), and N4On-4(-). In the second region, two positive and negative ion series are identified: (O2)pO(+/-) and (O2)pO2(+/-). Their yield distributions are fitted by the sum of two decreasing exponentials, whose decay constants are the same for all series. It is observed that the cluster ion desorption from solid oxygen is very similar to that of other frozen gases, but its yield distribution oscillates with a three- or six-atom periodicity, suggesting O3 or 3O2 units in the cluster structure, respectively. 相似文献
103.
da Silva VB Kawano DF Gomes Ada S Carvalho I Taft CA da Silva CH 《The journal of physical chemistry. A》2008,112(38):8902-8910
In this work, we have used molecular dynamics, density functional theory, virtual screening, ADMET predictions, and molecular interaction field studies to design and propose eight novel potential inhibitors of CDK2. The eight molecules proposed showed interesting structural characteristics that are required for inhibiting the CDK2 activity and show potential as drug candidates for the treatment of cancer. The parameters related to the Rule of Five were calculated, and only one of the molecules violated more than one parameter. One of the proposals and one of the drug-like compounds selected by virtual screening indicated to be promising candidates for CDK2-based cancer therapy. 相似文献
104.
Bode P Bueno MI Bortoleto GG Hoffmann G van den Ingh TS Rothuizen J 《Analytical and bioanalytical chemistry》2008,390(6):1653-1658
The heritability of chronic hepatitis in the Labrador Retriever is studied with the aim of identifying the related gene mutation.
Identification of cases and controls is largely based on instrumental neutron activation analysis (INAA) Cu determination
in liver biopsies. The burden for these companion animals may be reduced if nail clippings and hair (fur) could serve as a
noninvasive indicator for the hepatic Cu concentrations. No correlation was found between hepatic Cu concentrations and Cu
concentrations in hair and nail samples. However, hair and nail samples were also analyzed by X-ray tube excitation, taking
advantage of the X-ray Compton, Rayleigh, and Raman scattering which reflects the organic components such as the type of melanin.
Principal component analysis provided first indications that some differentiation between healthy and sick dogs could indeed
be obtained from hair and nail analysis.
Figure Principal component analysis of scattered region of x-ray fluorescence spectra of Labrador dog nails, demonstrating the differentiation
towards dogs with high and low Cu liver levels (respectively positive and negative PC2 values) reflecting hepatitis, as well
as gender (PC1: negative values for female and positive values for males) 相似文献
105.
Joshua A. Silveira William Danielson Mark E. Ridgeway Melvin A. Park 《International Journal for Ion Mobility Spectrometry》2016,19(2-3):87-94
Trapped ion mobility spectrometry (TIMS) is a versatile high resolution technique that provides the user with the flexibility to adjust the mobility range of interest, duty cycle (up to 100 %), and resolving power (up to ~300) according to the application requirements. Furthermore, TIMS offers the flexibility of operating as either a mobility-selective or conventional ion funnel, thus permitting ion mobility separations to be turned on or off. Here, we extend the flexibility of TIMS by introducing multilinear and nonlinear scanning methods that allow enhanced resolution in user-defined mobility regions. The performance of the new method is demonstrated using a variety of nonlinear scan functions that allow the resolving power to be continuously varied across the mobility spectrum. Further, we demonstrate that mobility analysis can be targeted over disparate regions using a multilinear scan function. In this example, high resolution mobility analysis is targeted on two analytes on opposite ends of a mobility range, while other ions that fall between the regions of interest remain unanalyzed. Using this approach, the resolving power for targeted species was increased by a factor of two over the conventional linear scanning approach (R ~60 versus ~120) without reducing the duty cycle of the TIMS measurement. Importantly, in such an analysis, ions in the untargeted regions are not mobility analyzed, however, they are also not discarded. Rather, these ions are ejected for downstream mass analysis. In this sense, TIMS bridges the gap between dispersive and scanning mobility techniques. That is, TIMS disperses ions according to their elution voltage, however, TIMS can also perform target mobility analyses without eliminating untargeted ions. 相似文献
106.
107.
This work compares the performance of X-ray tube induced and synchrotron induced energy dispersive X-ray fluorescence in generating scattering profiles when organic samples are irradiated. In the first case, this effect produces sharper peaks, well defined in the spectra, whereas synchrotron-induced scatter are seen as broad bands. These effects may be used for classifying simple materials like graphite, coke, activated carbon and carbon nanotubes, all having the same composition but different structures, using multivariate data analysis. In a second sample set, the method was applied to liquid samples of different alcohols (methanol, ethanol, 1-propanol and 2-propanol). Classifications were obtained in both cases independent of the X-ray source (synchrotron radiation or X-ray tube radiation), showing that the use of chemometric tools combined with X-ray spectrometry can efficiently distinguish organic samples by using scattering effects. 相似文献
108.
Lopes CB Pacheco MT Silveira L Duarte J Cangussú MC Pinheiro AL 《Journal of photochemistry and photobiology. B, Biology》2007,89(2-3):125-130
Bone fractures are lesions of different etiology; may be associated or not to bone losses; and have different options for treatment, such as the use of biomaterials, guided bone regeneration, techniques considered effective on improving bone repair. Laser therapy has also been shown to improve bone healing on several models. The association of these three techniques has been well documented by our group using different models. This study aimed to assess, through Raman spectroscopy, the incorporation of calcium hydroxyapatite (CHA approximately 958 cm(-1)) on the repair of complete tibial fractures in rabbits treated with wire osteosynthesis (WO); treated or not with laser therapy; and associated or not with the use of BMPs and/or Guided Bone Regeneration. Complete tibial fractures were created in 12 animals that were divided into four groups: WO; WO+BMPs; WO+laser therapy; and WO+BMPs+laser therapy. Irradiation started immediately after surgery; was repeated at every other day during 2 weeks; and was carried out with lambda 790 nm laser light (4 J/cm(2) per point, 40 mW, phi approximately 0.5 cm(2), 16J per session). Animal death occurred after 30 days. Raman spectroscopy was performed at both the surface and the depth of the fracture site. Statistical analysis showed significant difference on the concentrations of CHA between surface and depth. The analysis in each of the areas showed at the depth of the fracture significant differences between all treatment groups (p<0.0001). Significant differences were also seen between WO+BMPs+laser therapy and WO (p<0.001) and WO+laser therapy (p<0.001). At the surface, significant difference was seen only between the treatment groups and the non-fractured subjects (p=0.0001). However, no significant difference was seen between the treatment groups (p=0.14). It is concluded that the use of NIR laser therapy associated to BMPs and GBR was effective in improving bone healing on the fractured bones as a result of the increasing deposition of CHA measured by Raman spectroscopy. 相似文献
109.
Silveira PC Streck EL Pinho RA 《Journal of photochemistry and photobiology. B, Biology》2007,86(3):279-282
Laser therapy is used in many biomedical sciences to promote tissue regeneration. Many studies involving low-level laser therapy have shown that the healing process is enhanced by such therapy. In this work, we evaluated mitochondrial respiratory chain complexes II and IV and succinate dehydrogenase activities in wounds after irradiation with low-level laser. The animals were divided into two groups: group 1, the animals had no local nor systemic treatment and were considered as control wounds; group 2, the wounds were treated immediately after they were made and every day after with a low-level laser (AsGa, wavelength of 904 nm) for 10 days. The results showed that low-level laser therapy improved wound healing. Besides, our results showed that low-level laser therapy significantly increased the activities of complexes II and IV but did not affect succinate dehydrogenase activity. These findings are in accordance to other works, where cytochrome c oxidase (complex IV) seems to be activated by low-level laser therapy. Besides, we showed, for the first time, that complex II activity was also activated. More studies are being carried out in order to evaluate other mitochondrial enzymes activities after different doses and irradiation time of low-level laser. 相似文献
110.
Magnetic characterization of maghemite nanoparticles dispersed in surface-treated polymeric template
J. A. H. Coaquira A. F. R. Rodriguez J. G. Santos L. B. Silveira A. C. Oliveira V. K. Garg F. Q. Soares D. Rabelo P. C. Morais 《Hyperfine Interactions》2007,176(1-3):113-117
Magnetic characterization of maghemite nanoparticles dispersed in a polymeric template and treated under different chemical processes is reported in this work. Particle size estimated from magnetic measurements, D M?≈?10 nm, for the free-surfactant sample, is consistent with values determined from XRD analysis and TEM images. The magnetic collapse of sextets towards a quadrupole doublet as the temperature is increased reveals the thermal relaxation of smaller $\upgamma $ -Fe2O3 nanoparticles. Magnetic measurements show a strong irreversibility between ZFC and FC curves suggesting the occurrence of particle–particle interaction. 相似文献