基于吸收系数的生脉注射液中聚山梨酯80含量测定新方法

聚山梨酯80又名吐温80，为一种亲水型非离子表面活性剂，是食品、保健品和药品中常用的辅料，作为增溶剂和澄清剂广泛用于中药注射剂。近年来，不良反应的发生使得聚山梨酯80的质量和应用愈加受到重视，有研究认为其加入可能引起注射剂不良反应增加。为避免超量使用，有必要对该辅料的投料加以严格控制。中药注射剂中聚山梨酯80的含量测定是当下研究的热点和难点，可以通过分光光度法、分子排阻-蒸发光散射检测法(SEC-ELSD)、液质联用法(LC-MS)直接测定，也可以水解后法经液相色谱-紫外检测法(HPLC-UV)或气相色谱法(GC)间接测定。但由于聚山梨酯80为聚氧乙烯聚合数目不同的混合物、不同厂家生产的聚山梨酯80化学组分及比例存在较大差异，难以采用统一的转换公式或对照品准确定量。此外，中药注射剂的复杂基质造成的假阳性干扰也对定量提出了挑战。为解决以上问题，以生脉注射液为例，提出基于吸收系数的中药注射剂中聚山梨酯80含量测定新方法。优化检测波长、显色剂种类、液液萃取过程振荡和静置时间，在6个不同品牌仪器上测得聚山梨酯80-硫氰酸钴配合物的吸收系数(E1%_{1 cm})为104.23，相对标准偏差(RSD)为2.08%。生脉注射液稀释10倍后，精密量取供试品溶液1.0 mL，精密加入硫氰酸钴溶液10 mL，二氯甲烷20 mL，涡旋振荡3 min。将混合液移至分液漏斗中，静置30 min，取下层二氯甲烷液，将前1 mL弃去，接收约15 mL，在320 nm处测定吸光度，再根据Lambert-Beer定律，利用获得的吸收系数计算得到聚山梨酯80的含量。方法阴性无干扰，精密度和重复性相对标准偏差均低于3%，平均回收率为98.42%。为进一步验证方法的准确性，分别采用吸收系数法和标准曲线法测定了2个厂家的10批生脉注射液，并与实际投料量比较。配对t检验结果表明，当置信度为95%时，两种方法无显著性差异，吸收系数法测得结果与企业生产中聚山梨酯的实际投料量也无显著性差异。研究采用前人未采用的、灵敏度更高的320 nm为检测波长，显著降低了基质干扰，克服了中药注射剂中聚山梨酯80测定结果与实际投料量难以吻合的问题。吸收系数法无需使用对照品，亦不用制备标准曲线，可为中药注射剂中聚山梨酯80的检查标准提供切实可行的解决方案。所建方法灵敏、准确、快速、简便，为含聚山梨酯80制剂的质量控制提供了关键常数及新的思路。     

General Formation of Macro-/Mesoporous Nanoshells from Interfacial Assembly of Irregular Mesostructured Nanounits

Mesoporous core–shell nanostructures with controllable ultra-large open channels in their nanoshells are of great interest. However, soft template-directed cooperative assembly to mesoporous nanoshells with highly accessible pores larger than 30 nm, or even above 50 nm into macroporous range, remains a significant challenge. Herein we report a general approach for precisely tailored coating of hierarchically macro-/mesoporous polymer and carbon shells, possessing highly accessible radial channels with extremely wide pore size distribution from ca. 10 nm to ca. 200 nm, on diverse functional materials. This strategy creates opportunities to tailor the interfacial assembly of irregular mesostructured nanounits on core materials and generate various core–shell nanomaterials with controllable pore architectures. The obtained Fe,N-doped macro-/mesoporous carbon nanoshells show enhanced electrochemical performance for the oxygen reduction reaction in alkaline condition.     

超临界流体色谱流程设计及其应用

本文设计了多功能超临界流体色谱流程,流程中包括毛细管/微填充柱SFC,GC,计算机控制温度、压力、密度及信号采集、处理,配置有超临界流体萃取池,解决了超临界流体色谱分流口易堵问题。利用该流程,将石腊、DC-200气相色谱固定相、黄油、蜂蜡、救心油、红花油等样品进行超临界流体色谱分离。     

Optic Fiber Interferometer for Absolute Distance Measurement

1.IntroductionAbsolutedistancemeasurementisfarfromanewtopic.However,itisstillafieldstimulatinggreatinterestsnowadaysduetoitSimportantroleinmanufacturingandassembly['J.SincethegreatsuccessachievedbyMichelsonandBenoitwhentheyfirstdevelopedaninterferometertodeterminethestandardmeterintermsofthemonochromaticredcadmiumline,theopticinterferometerhasbeenprovedtobeoneofthemostpreciseandefficientwayindisplacementmeasurementbecauseofitshighdiscriminationandsimplestructure.However,thetraditionalinterfe…     

Local and Parallel Finite Element Algorithms for Eigenvalue Problems

Abstract Some new local and parallel finite element algorithms are proposed and analyzed in this paper foreigenvalue problems.With these algorithms, the solution of an eigenvalue problem on a fine grid is reduced tothe solution of an eigenvalue problem on a relatively coarse grid together with solutions of some linear algebraicsystems on fine grid by using some local and parallel procedure.A theoretical tool for analyzing these algorithmsis some local error estimate that is also obtained in this paper for finite element approximations of eigenvectorson general shape-regular grids.     

杂多酸催化合成乙酸乙酯

回流吸附法制备的负载型12-钨磷酸(HPW/C)是合成乙酸乙酯的高效催化剂。最佳反应条件下乙醇转化率达96％,酯化选择性100％。催化剂的高活性是由于HPW在活性炭上高度分散,使活性位增多,有效酸量增大。HPW/C还具有热稳定性高和不易流失等优点。     

准移动闭塞系统的元胞自动机模型及列车延迟传播规律的研究

在NaSch模型的基础上，针对铁路交通的特点提出一种用于模拟准移动闭塞系统的元胞自动机模型.应用该模型模拟了准移动闭塞系统列车延迟传播的交通现象，分析了准移动闭塞系统中的轨道定位单元长度、发车时间间隔、初始延迟时间等因素对列车延迟传播的影响. 关键词： 元胞自动机 交通流 准移动闭塞     

Structural and thermodynamic properties of AlB2 compound

We employ a first-principles plane wave method with the relativistic analytic pseudopotential of Hartwigsen, Goedecker and Hutter (HGH) scheme in the frame of DFT to calculate the equilibrium lattice parameters and the thermodynamic properties of AlB₂ compound with hcp structure. The obtained lattice parameters are in good agreement with the available experimental data and those calculated by others. Through the quasi-harmonic Debye model, obtained successfully are the dependences of the normalized lattice parameters a/a₀ and c/c₀ on pressure P, the normalized primitive cell volume V/V₀ on pressure P, the variation of the thermal expansion α with pressure P and temperature T, as well as the Debye temperature \Theta_D and the heat capacity C_V on pressure P and temperature T.     

COMPACT COUPLED LINEAR TAPERED LINE BANDPASS FILTER WITH TWO TRANSMISSION ZEROS

A new compact bandpass filter composed of two coupled linear tapered line resonators (LTLRs) is designed. The two resonators are arranged in different layers. The filter has two transmission zeros on both sides of the passband. It has small size and steep response below its passband. It is also shown that this filter has 0.6 dB low insertion loss at the centre frequency and 10.5% 3dB bandwidth. This work was supported by the Development Foundation of Shanghai Educational Committee (217608) and Shanghai Leading Academic Discipline Project (T0102).     

基于Terminal滑模的有限时间混沌同步实现

提出了混沌同步有限时间实现问题，将Terminal滑模控制技术与混沌同步问题相结合，把同步问题视为响应系统的跟踪问题，给出了由线性滑模函数引入非线性项构造Terminal滑模面的充分条件，以及相应Terminal滑模控制器.以主从Duffing系统为例研究验证同步策略的可行性和有效性. 关键词： Terminal滑模 混沌同步 Duffing系统