An efficient stereoselective synthesis of aminocyclohexenes from 7-azanorbornenes via LiAlH4 mediated tandem double bond migration-ring opening sequence

hNav1.7 had received great interest in the past decade owing to its attractive mechanism of actions in pain processing pathway. More recently, we developed a series of efficacious hNav1.7 inhibitors for analgesic, which were characterized with a novel aminocyclohexene as pharmacophore. Herein, we reported our synthetic efforts to construct the unique scaffold, which can be rapidly accessed from readily available 7-azanorbornenes via an unexpected catalyst-free, LiAlH₄ mediated tandem double bond migration-ring opening sequence. A probable mechanism was proposed to illuminate the good regio- and stereoselectivity.     

Rational solutions for a combined (3 + 1)-dimensional generalized BKP equation

Nonlinear Dynamics - In this paper, we focus on the rational solutions for a combined (3 + 1)-dimensional generalized BKP equation. By using the symbolic computation with Maple,...     

M-lump and interactive solutions to a (3 $${+}$$ + 1)-dimensional nonlinear system

Nonlinear Dynamics - This paper aims at computing M-lump solutions for the $$(3+1)$$ -dimensional nonlinear evolution equation. These solutions in all directions decline to an identical state...     

Efficient and widely applicable oxidation method of tribromomethyl carbinols with PCC

An efficient and widely applicable oxidation method of tribromomethyl carbinols in the presence of pyridinium chlorochromate has been developed with excellent yields up to 96%. This method was well applied for the oxidation of a variety of aromatic, aliphatic, and heterocyclic tribromomethyl carbinols.     

A Mesoporous Сarbon Prepared by Сarbonizing Cu(II)–p-Phenylenediamine Polymer for the Adsorption of Methyl Orange from Water

Russian Journal of Physical Chemistry A - A new mesoporous carbon containing nitrogen and copper was prepared by carbonizing a polymer obtained by blending p-phenylenediamine, copper(II) sulfate,...     

N-substituted-3(10H)-acridones as visible-light photosensitizers for organic photoredox catalysis

N-Substituted-3(10H)-acridones have been established as visible-light organic photocatalyst. These photosensitizers are efficient for oxidative coupling reaction of N-aryl tetrahydroisoquinolines with various nucleophiles. Notably, N-methyl-3(10H)-acridone (Ia) is stable and can be effectively prepared. It is a water-soluble and atom-economic catalyst, and thus holds promise for green chemical applications. Mechanistic studies confirm a single electron transfer (SET)-induced radical process and a rate-limiting step. Analysis of the photocatalytic reactivity?structure relationship reveals that the acridones are robust and tunable photosensitizers for photoredox catalysis.     

Offline Arbitrated Quantum Blind Dual-Signature Protocol with Better Performance in Resisting Existential Forgery Attack

In this paper, we present an offline arbitrated quantum blind dual-signature protocol by using four-particle entangled Greenberger-Horne-Zeilinger(GHZ) states. By using the special relationship of four-particle GHZ states, we can not only support the security of quantum signature, but also guarantee the anonymity of the message owner. In our protocol, the authority of the arbitrator has been reduced, i.e., he will not help the receiver verify the signature in the verification. Compared with the previous quantum blind signature protocols, the presented arbitrator is offline. Finally, the security analysis and discussion are proposed.     

Potential influence on drug efficacy from interaction of tartrazine and trypsin

The extent to which drugs combine with trypsin is influenced by the interaction of tartrazine and trypsin, which may cause overdose or underdose of drugs. Therefore, the interaction of tartrazine and trypsin is investigated by methods of spectrometry in this paper. The binding rate of tartrazine to trypsin is 80.95–95.71% at 310?K, and Hill’s coefficients are almost 1. The effect of tartrazine on trypsin structure was studied by synchronous and circular dichroism. The results showed that the binding of tartrazine and trypsin induced the conformational change of trypsin, and quenched the endogenous fluorescence in trypsin. The results of molecular docking revealed that tartrazine is located in the catalytic active site of trypsin, and is consistent with that of experimental calculation.