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691.
It is well known that UV exposure of human skin induces DNA damage, and the cumulative effect of such repeated damage is an important contributor to the development of skin cancer. Here, we demonstrate UV dose- and time-dependent induction of DNA damage in the form of cyclobutane pyrimidine dimers (CPD) in skin cells following a single exposure of human skin to UV radiation. CPD+ cells were identified by an immunohistochemical technique using monoclonal antibodies to thymine dimers. The percentage of CPD+ cells was UV dose-dependent, even a suberythemal (0.5 minimal erythemal dose [MED]) dose resulted in detectable level of cells that contained pyrimidine dimers. Forty-eight hours after irradiation the percent of total epidermal cells positive for CPD ranged from 19 +/- 8, 36 +/- 10, 57 +/- 12 and 80 +/- 10, and total percent dermal cells positive for CPD ranged from 1 +/- 1, 7 +/- 3, 16 +/- 3 and 20 +/- 5, respectively, following 0.5, 1.0, 2.0 and 4.0 MED. CPD were also observed in deeper reticular dermis, which suggest the penetrating ability of UV radiation into the skin. The change in CPD+ cells from 0.5 to 240 h post-UV exposure in both epidermal and dermal compartments of the skin was also quantitated. CPD+ cells were observed in skin biopsies at early time points after UV exposure which remained elevated for 48 h, then declined significantly by 3 days post-UV. A close examination of the skin at and after 3 days following UV exposure indicates the significant removal of DNA damaged cells from the epidermis. Ten days after UV exposure the levels of CPD+ cells in both epidermis and dermis were not significantly different from that in unirradiated skin. 相似文献
692.
Toshikatsu Koga Kazunori Matsui 《Zeitschrift für Physik D Atoms, Molecules and Clusters》1993,27(2):97-102
Hylleraas wave functions composed of the optimally combinedN terms (2 N 20) are presented for two-electron atoms with nuclear chargesZ = 1 (H–), 2(He), 3(Li+), 5(B3+), and 10(Ne8+). The spherically-averaged electron density (r) and electron-pair densityh(r
12) are constructed in a simple and analytical functional form from the 20-term functions. Comparison of several one- and two-electron moments r
k
and r
12
k
shows that the present density functions have near-exact accuracy. 相似文献
693.
Yoshiki Sohrin Kenji Isshiki Eiichiro Nakayama Sorin Kihara Masakazu Matsui 《Analytica chimica acta》1989
The simultaneous determination of tungsten and molybdenum in sea water is based on preconcentration by column extraction with 7-(1-vinyl-3,3,5,5-tetramethylhexyl)-8-quinolinol (Kelex- 100) resin, and measurement of the polarographic catalytic currents obtained in a solution of chlorate, benzilic acid and 2-methyl-8-quinolinol. When the concentration factor is 50, the detection limits are 2.4 pM for tungsten and 17 pM for molybdenum (for a signal-to-noise ratio of 3). The precision of the determination is ca. 10% for 67 pM tungsten and ca. 5% for 106 nM molybdenum in sea water (n=4). Results for sea water and other natural waters are presented. 相似文献
694.
Novel prolinol carrying two perfluorohexylethyl groups at the α-position was prepared from l-proline as a starting chiral substrate. Catalytic asymmetric reduction of various ketones, including mono-, di-, and trifluoromethylated acetophenones, using fluorous oxazaborolidines derived from fluorous prolinol afforded the corresponding alcohols in good to excellent yields and with high enantioselectivities (up to 93.2% ee). The fluorous prolinol was recovered without any fluorous solvents or silica gel by simply cooling the organic phase and filtration. 相似文献
695.
Effect of l-menthol on the permeation of indomethacin, mannitol and cortisone through excised hairless mouse skin. 总被引:2,自引:0,他引:2
K Katayama O Takahashi R Matsui S Morigaki T Aiba M Kakemi T Koizumi 《Chemical & pharmaceutical bulletin》1992,40(11):3097-3099
The effect of l-menthol on the skin permeability of mannitol, cortisone or indomethacin was examined by an in vitro penetration technique with hairless mouse skin. The donor solution was prepared with phosphate buffered saline, ethanol:buffered saline (20:80, v/v) or ethanol:buffered saline (20:80, v/v) containing 1% (w/v) l-menthol. Although ethanol showed little enhancing effect, l-menthol in an aqueous ethanol vehicle at pH 7.4 increased the permeability coefficients of mannitol and indomethacin by about 100 times that of the control (an aqueous vehicle) and increased that of cortisone by about 10 times. l-Menthol, however, scarcely enhanced the penetration of indomethacin at pH 3.0, the majority of the species being in unionized form. These results suggested that the menthol-ethanol-aqueous system enhanced skin permeability through a direct effect on the polar and/or lipid pathways, while the thermodynamic activity of the penetrant molecule in the delivery vehicle might also influence the effectiveness of the penetration enhancer. 相似文献
696.
697.
698.
Yoshikuni Uchida Yu-Ichiro Nobu Ichiro Momiji Kazunori Matsui 《Journal of Sol-Gel Science and Technology》2000,19(1-3):705-709
Silica-pillared clays were prepared by reacting Na-montmorillonite aqueous suspensions with (3-aminopropyl)triethoxysilane (APTEOS). It was indicated that cubic octamers [NH
3
+
(CH2)3SiO3/2]8 derived from APTEOS are intercalated with two different conformations of the alkyl chains. Namely, the cubic octamers are intercalated with the alkyl chains parallel to the silicate layers at low concentration of APTEOS, and then intercalated with the alkyl chains normal to the silicate layers with increase in APTEOS. Gels were prepared from the reaction of APTEOS with acetic acid and by the conventional sol-gel process using (3-aminopropyl)trimethoxysilane (APTMOS). The luminescence spectra of the gel prepared by the sol-gel process and the intercalated clays were similar to that of silica gels. The gel from APTEOS with acetic acid showed broad visible luminescence. The luminescence spectra and the structures of these materials were described. 相似文献
699.
The principle and design of a new photoemission electron microscope (PEEM), which is called Stereo-PEEM, is described here. Stereo-PEEM can display not only the image of microscopic materials but also the angular distribution of high-energy photoelectrons up to about ±60°, which is about 100-fold the acceptance angle of usual PEEM. This wide angle acceptance for high-energy photoelectrons enables the three-dimensional (3D) display of atomic structure as well as the 3D electronic structure of individual micromaterials. The 3D atomic structure of a sample can be observed directly by taking stereophotographs using photons with angular momentum. 相似文献
700.
A double column-switching HPLC method with naphthalene-2,3-dialdehyde (NDA) was applied for determination of two plasma antihypertensive peptides, Val-Tyr (VY) and Ile-Val-Tyr (IVY). After a first separation on a Phe-ODS column, double heart-cuts of the retention time corresponding to NDA-VY and NDA-IVY elutions were successfully separated on an analytical ODS column: 60% acetonitrile in 0.1% trifluoroacetic acid containing 5 mM sodium 1-octanesulfonate at 1.0 mL/min. Within-run coefficients of variation were 1.73% and 4.73% for VY and IVY, respectively. 相似文献