Nanowire acting as a superconducting quantum interference device

We present the results from an experimental study of the magnetotransport of superconducting wires of amorphous indium-oxide having widths in the range 40-120 nm. We find that, below the superconducting transition temperature, the wires exhibit clear, reproducible, oscillations in their resistance as a function of magnetic field. The oscillations are reminiscent of those that underlie the operation of a superconducting quantum interference device.     

Return of the quantum cosmic censor

The influential theorems of Hawking and Penrose demonstrate that spacetime singularities are ubiquitous features of general relativity, Einstein's theory of gravity. The utility of classical general relativity in describing gravitational phenomena is maintained by the cosmic censorship principle. This conjecture, whose validity is still one of the most important open questions in general relativity, asserts that the undesirable spacetime singularities are always hidden inside of black holes. In this Letter we reanalyze extreme situations which have been considered as counterexamples to the cosmic censorship hypothesis. In particular, we consider the absorption of fermion particles by a spinning black hole. Ignoring quantum effects may lead one to conclude that an incident fermion wave may over spin the black hole, thereby exposing its inner singularity to distant observers. However, we show that when quantum effects are properly taken into account, the integrity of the black-hole event horizon is irrefutable. This observation suggests that the cosmic censorship principle is intrinsically a quantum phenomena.     

Essay: Cosmic Censorship: The Role of Quantum Gravity

The cosmic censorship hypothesis introduced by Penrose thirty years ago is still one of the most important open questions in classical general relativity. In this essay we put forward the idea that cosmic censorhip is intrinsically a quantum gravity phenomena. To that end, we construct a gedanken experiment in which cosmic censorship is violated within the purely classical framework of general relativity. We prove, however, that quantum effects restore the validity of the conjecture. This suggests that classical general relativity is inconsistent and that cosmic censorship might be enforced only by a quantum theory of gravity.     

Synthesis and Cytotoxic Activity of Novel Pyrazoline Derivatives against Human Lung Tumor Cell Line (A549)

In the present investigation, a series of 5‐(‐4‐(substituted)phenyl)‐3‐(4‐hydroxy‐3‐methylphenyl)‐4,5‐dihydro‐1H‐1‐pyrazolyl‐2‐toluidino methane thione and 5‐(substituted)phenyl‐3‐(4‐hydroxy‐3‐methylphenyl)‐4,5‐dihydro‐1H‐1‐pyrazolyl‐2‐methoxy anilino methane thiones were synthesized and were examined against human lung tumor cell line (A549) in vitro using the MTT assay system. Among those tested, 5‐(4‐flurophenyl)‐3‐(4‐hydroxy‐3‐methylphenyl)‐4,5‐dihydro‐1H‐1‐pyrazolyl‐2‐toluidino methane thione & 5‐(4‐chlorophenyl)‐3‐(4‐hydroxy‐3‐methylphenyl)‐4,5‐dihydro‐1H‐1‐pyrazolyl‐2‐methoxy anilino methane thione showed more potent cytotoxicity against human lung tumor cell line (A549) than the other synthesized compounds.     

Synthesis and antitubercular activity of substituted novel pyrazoline derivatives

A series of 2-2-methoxy-4-[5-(substituted phenyl)1-(4-pyridylcarbonyl)-4,5-dihydro-1H-3-pyrazolyl] phenoxyacetic acid were synthesized by the reaction between isoniazid (INH) and chalcones, and were tested for their antimycobacterial activity in vitro against Mycobacterium tuberculosis H37Rv and INH resistant M. tuberculosis using BACTEC-460 radiometric system and agar dilution method. Among the synthesized compounds, Compounds II 2-4-[5-(4-hydroxyphenyl)-1-(4-pyridylcarbonyl)-4,5-ihydro-1H-3-pyrazolyl]-2-methoxy phenoxy acetic acid was found to be most active agent against M. tuberculosis H37Rv (MTB) and INH resistant M. tuberculosis (INHR-MTB), with minimum inhibitory concentration of 0.12 microM, when compared to INH 5.6-fold more active against MTB and 78-fold more active against INHR-MTB, respectively.     

Balance of enthalpy and entropy in depletion forces

Solutes added to solutions often dramatically impact molecular processes ranging from the suspension or precipitation of colloids to biomolecular associations and protein folding. Here we revisit the origins of the effective attractive interactions that emerge between and within macromolecules immersed in solutions containing cosolutes that are preferentially excluded from the macromolecular interfaces. Until recently, these depletion forces were considered to be entropic in nature, resulting primarily from the tendency to increase the space available to the cosolute. However, recent experimental evidence indicates the existence of additional, energetically-dominated mechanisms. In this review we follow the emerging characteristics of these different mechanisms. By compiling a set of available thermodynamic data for processes ranging from protein folding to protein–protein interactions, we show that excluded cosolutes can act through two distinct mechanisms that correlate to a large extent with their molecular properties. For many polymers at low to moderate concentrations the steric interactions and molecular crowding effects dominate, and the mechanism is entropic. To contrast, for many small excluded solutes, such as naturally occurring osmolytes, the mechanism is dominated by favorable enthalpy, whereas the entropic contribution is typically unfavorable. We review the available models for these thermodynamic mechanisms, and comment on the need for new models that would be able to explain the full range of observed depletion forces.     

Precrystalline Aggregates Enable Control over Organic Crystallization in Solution

Understanding and controlling organic crystallization in solution is a long‐standing challenge. Herein, we show that crystallization of an aromatic amphiphile based on perylene diimide in aqueous media involves initially formed amorphous spherical aggregates that evolve into the crystalline phase. The initial appearance of the crystalline order is always confined to the spherical aggregates that are precursors for crystalline evolution. The change in the solvation of the prenucleation phase drives the crystallization process towards crystals that exhibit very different structure and photofunction. The initial molecular structure and subsequent crystal evolution can be regulated by tuning the hydrophobicity at various stages of crystallization, affording dissimilar crystalline products or hindering crystallization. Thus, the key role of the precrystalline states in organic crystal evolution enables a new strategy to control crystallization by precrystalline state manipulation.     

Black Hole Evaporation Entails an Objective Passage of Time

Time's apparent passage has long been debated by philosophers, with no decisive argument for or against its objective existence. In this paper we show that introducing the issue of determinism gives the debate a new, empirical twist. We prove that any theory that states that the basic laws of physics are time-symmetric must be strictly deterministic. It is only determinism that enables time reversal, whether theoretical or experimental, of any entropy-increasing process. A contradiction therefore arises between Hawking's [1] argument that physical law is time-symmetric and his controversial claim [2] that black-hole evaporation introduces a fundamental unpredictability into the physical world. The latter claim forcibly entails an intrinsic time-arrow independent of boundary conditions. A simulation of a simple system under time reversal shows how an intrinsic time arrow re-emerges, destroying the time reversal, when even the slightest failure of determinism occurs. This proof is then extended to the classical behavior of black holes. We conclude with pointing out the affinity between time's arrow and its apparent passage.     

Superconductivity-related insulating behavior

We present the results of an experimental study of superconducting, disordered, thin films of amorphous indium oxide. These films can be driven from the superconducting phase to a reentrant insulating state by the application of a perpendicular magnetic field (B). We find that the high-B insulator exhibits activated transport with a characteristic temperature, TI. TI has a maximum value (TpI) that is close to the superconducting transition temperature (Tc) at B=0, suggesting a possible relation between the conduction mechanisms in the superconducting and insulating phases. Tp(I) and Tc display opposite dependences on the disorder strength.