A selective and sensitive liquid chromatography–mass spectrometric method in ESI (+ve) mode was developed and validated completely in human plasma. Clonidine and IS, carbamazapine, were extracted from human plasma via liquid–liquid extraction with ethyl acetate. Following evaporation under nitrogen, the residue was reconstituted with mobile phase and analyzed using API 4000 LC–MS–MS system. An isocratic program with binary mobile phases (0.1% formic acid in water and acetonitrile) was used to separate interference peaks by a C18 analytical column. Linearity range was 0.49–73.98 ng mL−1. The intra- and inter-day accuracy and precision were within acceptable limits (≤15%). This method was successfully applied to a single dose 25 μg tablets BE study of clonidine in healthy male volunteers.
Kiwi fruit (KF) (Actinidia deliciosa L.) are members of the Actinidia genus (Family Actinidiaceae). Previously these plants have confirm anti-diabetic, anti-oxidant, anti-inflammatory, antifungal, anticarcinogenic, hepatoprotective, anti-microbial etc. properties. The therapeutic efficacy of complex phytoconstituents found in fruit extracts has piqued the interest of pharmaceutical companies and academics alike. Methanolic extract of kiwi fruit (MEKF) was analyzed by gas chromatography-mass spectroscopy and yielded positive results signaling towards identification and characterization of therapeutic claims of this species in the traditional system. The antioxidant activity of MEKF was determined by the most suitable DPPH method. The most significant constituents found in MEKF are 2-cyclohexylpiperidine (0.58%), phenol, 2,4-bis(1,1-dimethylethyl)- (0.13%), 1,6-anhydro- β-d-glucopyranose (0.52%), dodecanoic acid (0.32%), 2-heptenoic acid, trimethylsilyl ester (2.84%), Tetradecanoic acid (1.87%), Neophytadiene (2.81%), Hexahydro farnesyl acetone (1.72%), Neophytadiene (0.97%), n-hexadecanoic acid (19.00%), Ethyl hexadecanoate (7.21%), Linoleic acid ethyl ester (0.23%), Phytol (4.74%), α-linolenic acid (16.73%), Ethyl (9z,12z)-9,12-octadecadienoate (2.92%), Octadecanoic acid (4.76%), Octadecanoic acid, 17-methyl-, methyl ester (1.68%), Phytol, acetate (0.15%), 2-Methylhexacosane (0.97%), Ethyl 9,12,15-octadecatrienoate (0.81%), Tetracontane (1.45%), α-tocospiro A (0.15%), α-tocospiro B (0.19%), 3.β-Acetoxystigmasta-4,6,22-triene (0.24%), Octacosane, 1-iodo (0.43%), 4,6-cholestadien-3.β-ol, benzoate (2.14%), γ.-Sitosterol (4.40%), and Tigogenin (2.32%). The found results in the analysis of the antioxidant activity of MEKF showed significant free radical scavenging capacity against DPPH-generated free radicals due to the presence of alkaloids, glycoside, terpenoids, vitamins, and some other reported compounds. In the pharmaceutical industry, GC-MS reports will be useful for identifying a wide range of phytoconstituents in polyherbal extracts and standardizing of plant materials. 相似文献
Copper is found to be an effective catalyst for the preparation of alkynylphophonates. A novel copper-catalyzed one-pot synthesis of alkynylphophonates from terminal alkynes and dialkyl phosphites is developed which involves the haloalkynes intermediates. This method provides a unique and alternative approach to the well-documented oxidative coupling or arylpropiolic acid strategies. 相似文献
Journal of Radioanalytical and Nuclear Chemistry - By using Durridge RAD7, onsite soil radon measurements were performed on 13 profiles and 65 points, across the known geological faults in district... 相似文献
In this study, a new pressure drop method has been used to investigate the kinetics of carbon dioxide reaction with aqueous blend of 2-amino-2-ethyl-1,3-propanediol (AEPD) with piperazine (PZ). The blending of a small amount of PZ with AEPD has a significant effect on the observed rate constant, kobs. It was observed that kobs values of the blend increased more than twice than the summation of kobs values of individual alkanolamines. The reaction kinetics in this study were modeled by assuming a termolecular mechanism. The addition of 0.1 mol/L of PZ to 1 mol/L AEPD exhibited an observed rate constant, kobs of 8824.1 s−1, which is comparable to other alkanolamine mixtures. Hence, PZ/AEPD mixtures can be potentially used for rapid carbon dioxide capture. 相似文献
Russian Journal of Coordination Chemistry - We have reported synthesis of complex [Rh(COD)(L{Me})Cl] (III), where L{Me} (II) is N-(1-methylpyridin-4(1H)-ylidene)benzamide and COD is... 相似文献
Nanostructured ZnSe-graphene/TiO2 was synthesized by a hydrothermal-assisted approach. ZnSe-graphene/TiO2 exhibited favorable adsorption of rhodamine B, a wide wavelength absorption range, and efficien... 相似文献
Recently, the nanofluids report multidisciplinary applications in the various era of engineering like engine cooling, solar energy production, cooling of engineering devices, diesel generator performance etc. Owing to such novel applications, the aim of current communication is to report the significances of bio-convection for unsteady Eyring Powell nanofluid due to bidirectional oscillatory stretching surface. The enrollment of buoyancy forces and magnetic impact are worked out to inspect the stability and thermal on set of nanofluids. Heat transformation features are explored by utilizing thermal radiation. Further, the characteristics of chemical reaction and activation energy have been considered for physical significance. Unlike traditional approach, the governing equations are not altered into ordinary set of equation but only diminish the independent variables. This task makes the non-dimensional equations in highly complicated from which the convergent technique via HAM is successfully implemented. The physical outcomes of dominant variables on profiles of microorganisms, concentration, temperature, velocity and skin frictions are conferred graphically while local motile density, Sherwood and Nusselt numbers are deliberated through different tables. It is noted that the amplitude of bidirectional shear stresses and velocities periodically get increase for higher material parameter. This analysis emphasized that concentration distribution augments for rising values of activation energy variable, whereas conflicting situation occurs for temperature difference parameter. Moreover, motile microorganism's distributions are diminished by improved values of bio-convected Peclet and bio-convected Lewis numbers. 相似文献
Journal of Thermal Analysis and Calorimetry - Heat transportation advancement in liquid is a crucial work which can be easily obtained via utilization of hybrid nanoparticles. Therefore, main... 相似文献