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981.
A chemo-electro-mechanical multi-field model, termed the multi-effect-coupling pH-electric-stimuli (MECpHe) model, has been
developed to simulate the response behavior of smart hydrogels subject to pH and electric voltage coupled stimuli when the
hydrogels are immersed in a pH buffer solution subject to an externally applied electric field. The MECpHe model developed
considers multiphysics effects and formulates the fixed charge density with the coupled buffer solution pH and electric voltage
effects, expressed by a set of nonlinear partial differential governing equations. The model can be used to predict the hydrogel
displacement and the distributive profiles of the concentrations of diffusive ionic species and the electric potential and
the fixed charge density in both the hydrogels and surrounding solution. After validation of the model by comparison of current
numerical results with experiment data extracted from the literature, one-dimensional steady-state simulations were carried
out for equilibrium of the smart hydrogels subject to pH and electric coupled stimuli. The effects of several important physical
conditions, including the externally applied electric voltage, on the distributions of the concentrations of diffusive ionic
species, the electric potential, the fixed charge density, and the displacement of the hydrogel strip were studied in detail.
The effects of the ionic strength on the bending deformation of the hydrogels under the solution pH and electric voltage coupled
stimuli are also discussed. 相似文献
982.
We determined the gas-phase acidities of two cysteine-polyalanine peptides, HSCA3 and HSCA4, using a triple-quadrupole mass spectrometer through application of the extended kinetic method with full entropy analysis. Five halogenated carboxylic acids were used as the reference acids. The negatively charged proton-bound dimers of the deprotonated peptides with the conjugate bases of the reference acids were generated by electrospray ionization. Collision-induced dissociation (CID) experiments were carried out at three collision energies. The enthalpies of deprotonation (Delta(acid)H) of the peptides were derived according to the linear relationship between the logarithms of the CID product ion branching ratios and the differences of the gas-phase acidities. The values were determined to be Delta(acid)H(HSCA3) = 317.3 +/- 2.4 kcal/mol and Delta(acid)H (HSCA4) = 316.2 +/- 3.9 kcal/mol. Large entropy effects (Delta(DeltaS) = 13-16 cal/mol K) were observed for these systems. Combining the enthalpies of deprotonation with the entropy term yielded the apparent gas-phase acidities (Delta(acid)G(app)) of 322.1 +/- 2.4 kcal/mol (HSCA3) and 320.1 +/- 3.9 kcal/mol (HSCA4), in agreement with the results obtained from the CID-bracketing experiments. Compared with that in the isolated cysteine residue, the thiol group in HSCA3,4 has a stronger gas-phase acidity by about 20 kcal/mol. This increased acidity is likely due to the stabilization of the negatively charged thiolate group through internal solvation. 相似文献
983.
Two new ruthenium(II) polypyridyl complexes
(1) (dtmi = 3-(pyrazin-2-yl)-as-triazino[5,6-f]-5-methoxylisatin) and
(2) (dtni = 3-(pyrazin-2-yl)-as-triazino[5,6-f]-5-nitroisatin) have been synthesized and characterized by elemental analysis,
FAB-MS, ES-MS and 1H-n.m.r. The DNA-binding patterns of complexes were investigated by spectroscopic titration, viscosity measurements and thermal
denaturation. The results indicate that the complexes (1) and (2) interact with calf thymus DNA (CT-DNA) by intercalative mode. Due to the withdrawing electronic substitutent in the intercalative
ligand, ptni, the DNA-binding affinity of the complexes (2) is larger than that complex (1) does. 相似文献
984.
The relationship between temperature and oxygen vacancy concentration is deduced in this paper. Based on the data of thermal weight-loss experiment, the formation enthalpies of congruent and several doped LN crystals have been calculated. It was found that the formation enthalpy of oxygen vacancies can be decreased evidently by doping valence-changeable ions. The experimental results were discussed and a new reduction process of the photorefractive LN crystal at a relatively low temperature was proposed, and the reduced crystals showed a good effect in practical use. 相似文献
985.
Iso-condensed heteroaromatic pyrroles 1 are 10 -electron aromatic compounds. They are of interest from both theoretical and synthetic points of view. They are the cyclic analogues of heteroaromatic ortho-quinodimethanes 2, and can react with dienophiles in a Diels-Alder reaction to give the synthetically useful cycloadducts 3. Many of them are also of potential pharmaceutical importance because they are isosteric with indoles. Iso-condensed heteroaromatic pyrroles 1 can be used also as the monomers for the synthesis of new conducting polymers 5 with special properties and characteristics. However, the methods for the efficient preparation of the iso-condensed heteroaromatic pyrroles are quite limited. Iso-condensed heteroaromatic pyrroles are generally unstable in acidic conditions and are easily oxidized by air. In our laboratories, we developed three methods for the preparation of this labile heterocyclic ring system under acidic, neutral, and basic conditions.1 Synthesis of the conjugated systems such as 6 for OLED applications will also be discussed. 相似文献
986.
The cyclization reactions of arylamines with 2-deoxy-D-ribose or glycals were reinvestigated in the current report. In the montmorillonite KSF- or InCl(3)-initiated reactions of 2-deoxy-D-ribose with arylamines, a pair of diastereomeric tetrahydro-2H-pyran-fused tetrahydroquinolines was obtained in a nearly 1:1 ratio where the structure of one diastereomer was incorrectly assigned in the literature. Meanwhile, the diastereoselectivity in InBr(3)-catalyzed cyclization of glycals with arylamines was also incorrectly reported previously. It was found that high diastereomeric selectivity was achieved only when a C5-substituted glycal was used; otherwise, a pair of diastereomers was obtained in moderate yield with 1:1 diastereomeric ratio. Furthermore, tetrahydrofuran-fused tetrahydroquinolines 5b and 5b' were also prepared successfully by using TBDPS-protected ribose as the glycal precursor and montmorillonite KSF as the activator. 相似文献
987.
Absalon C Fabre S Tarascou I Fouquet E Pianet I 《Analytical and bioanalytical chemistry》2011,401(5):1489-1499
Tannins represent a key element in red wine flavors, so researchers have made a lot of effort to try to understand the role
of their structure in wine taste in recent decades. We report some new routes to achieve a true structure–taste relationship
for the major tannins found in wine, which are procyanidins in their monomeric or oligomeric state. All these routes use synthetic
standards. New advances in their synthesis and their analyses using chromatographic methods, NMR spectroscopy, and mass spectrometry
to obtain more precise information about their chemical structure, including their stereochemistry and their precise degree
of polymerization and galloylation, are described. 相似文献
988.
Jian-fu Xu Fu-shuang Li Zi-ming Feng Jian-shuang Jiang Pei-cheng Zhang 《Chemistry of Natural Compounds》2011,47(2):218-219
A new sesquiterpenoid, malloapelin D (1), and a known schizandriside (2) were isolated from the roots of Mallotus apelta. Their structures were elucidated on the basis of spectroscopic methods including IR, MS, and 1D and 2D NMR. 相似文献
989.
Thermophysical properties and material modelling of acrylic bone cements used in vertebroplasty 总被引:1,自引:0,他引:1
Sebastian Kolmeder Alexander Lion Ralf Landgraf Jörn Ihlemann 《Journal of Thermal Analysis and Calorimetry》2011,105(2):705-718
The stabilization of osteoporotic vertebrae with acrylic bone cement, called vertebroplasty, is a common procedure in modern
surgery. However, the thermomechanical-chemically coupled material behaviour of curing bone cements makes the application
even for experienced surgeons difficult and can lead to potential complications like heat necrosis, leaking bone cement, embolisms
and postoperative load shifting. In order to reduce these potential complications, to minimize the risks and to better understand
the occurring effects, the thermophysical properties of a commercial acrylic bone cement were investigated in detail using
differential scanning calorimetry, volumetric dilatometry and temperature controlled rheometry. More specifically, the reaction
kinetics, the specific heat, the thermal conductivity, the thermal expansion, the chemical shrinkage as well as the mechanical
behaviour was studied during the reaction process of the bone cement. Furthermore, the explored material behaviour is described
by a customized material model that takes into account all observed effects. With the aid of this model the inhomogeneous
chemical, thermal and mechanical states that appear during the application and curing of acrylic bone cements, can be studied
by finite element treatment. 相似文献
990.
Köcher T Pichler P Mazanek M Swart R Mechtler K 《Analytical and bioanalytical chemistry》2011,400(8):2339-2347
The Mascot search algorithm is one of the most commonly used tools for protein identification. Tandem mass spectrometry data
searched against a protein sequence database is utilized for identifying peptides and proteins, each reported with a score.
Higher Mascot scores are associated with lower chances of random hits. The process of peak selection performed by the search
engine prior to the search is a critical aspect of the process. Here, we show that Mascot divides the MS/MS spectrum into
fixed m/z regions for peak selection, starting at the lowest m/z value of the peak list. Therefore, modifying the m/z range of the peak lists by insertion of a dummy peak with low m/z value changes the ensemble of peaks used for searching. As a consequence, Mascot peptide scores and search results are altered
significantly and a different subset of the peptides present in the sample is identified after processing. We further show
that the effect can be exploited and additional proteins and peptides can be identified by repeating the search with a combined
set of differently processed files, even when applying identical false-positive rates. 相似文献