全文获取类型
收费全文 | 1721篇 |
免费 | 100篇 |
国内免费 | 18篇 |
专业分类
化学 | 1126篇 |
晶体学 | 12篇 |
力学 | 77篇 |
数学 | 183篇 |
物理学 | 441篇 |
出版年
2024年 | 13篇 |
2023年 | 18篇 |
2022年 | 94篇 |
2021年 | 126篇 |
2020年 | 63篇 |
2019年 | 66篇 |
2018年 | 79篇 |
2017年 | 57篇 |
2016年 | 119篇 |
2015年 | 102篇 |
2014年 | 109篇 |
2013年 | 127篇 |
2012年 | 130篇 |
2011年 | 107篇 |
2010年 | 69篇 |
2009年 | 61篇 |
2008年 | 64篇 |
2007年 | 53篇 |
2006年 | 43篇 |
2005年 | 35篇 |
2004年 | 27篇 |
2003年 | 30篇 |
2002年 | 24篇 |
2001年 | 19篇 |
2000年 | 17篇 |
1999年 | 3篇 |
1998年 | 9篇 |
1997年 | 4篇 |
1996年 | 6篇 |
1995年 | 12篇 |
1994年 | 8篇 |
1993年 | 16篇 |
1992年 | 7篇 |
1991年 | 11篇 |
1990年 | 16篇 |
1989年 | 9篇 |
1988年 | 12篇 |
1987年 | 7篇 |
1986年 | 4篇 |
1985年 | 8篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1982年 | 7篇 |
1981年 | 6篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1977年 | 3篇 |
1976年 | 6篇 |
1975年 | 5篇 |
1973年 | 3篇 |
排序方式: 共有1839条查询结果,搜索用时 46 毫秒
71.
Gabriele Saleh Dr. Raffaella Soave Dr. Leonardo Lo Presti Prof. Riccardo Destro 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(10):3490-3503
The accurate, experimental charge density distribution, ρ( r ), of the potent antimalarial drug dihydroartemisinin (DHA) has been derived for the first time from single‐crystal X‐ray diffraction data at T=100(2) K. Gas‐phase and solid‐state DFT simulations have also been performed to provide a firm basis of comparison with experimental results. The quantum theory of atoms in molecules (QTAIM) has been employed to analyse the ρ( r ) scalar field, with the aim of classifying and quantifying the key real‐space elements responsible for the known pharmacophoric features of DHA. From the conformational perspective, the bicyclo[3.2.2]nonane system fixes the three‐dimensional arrangement of the 1,2,4‐trioxane bearing the active O? O redox centre. This is the most nucleophilic function in DHA and acts as an important CH???O acceptor. On the contrary, the rest of the molecular backbone is almost neutral, in accordance with the lipophilic character of the compound. Another remarkable feature is the C? O bond length alternation along the O‐C‐O‐C polyether chain, due to correlations between pairs of adjacent C? O bonds. These bonding features have been related with possible reactivity routes of the α‐ and β‐DHA epimers, namely 1) the base‐catalysed hemiacetal breakdown and 2) the peroxide reduction. As a general conclusion, the base‐driven proton transfer has significant non‐local effects on the whole polyether chain, whereas DHA reduction is thermodynamically favourable and invariably leads to a significant weakening (or even breaking) of the O? O bond. The influence of the hemiacetal stereochemistry on the electronic properties of the system has also been considered. Such findings are discussed in the context of the known chemical reactivity of this class of important antimalarial drugs. 相似文献
72.
Various types of crystalline cellulose consisting of group I (cell I, IIII, IVI) and group II (cell II, IIIII, IVII) prepared from cotton linter were adjusted for their degree of polymerization (DP) as starting materials. These celluloses were then treated by semi-flow hot-compressed water (HCW) at 230–270 °C/10 MPa/2–15 min to study their decomposition behaviors. The treatments performed resulted in residues of celluloses and water-soluble (WS) portions. Consequently, the crystallinity of the residues was found to remain the same, but the DP was reduced as the temperature increased. Additionally, X-ray diffractometry and Fourier transform-infrared analyses demonstrated that crystallographic changes occurred for residues of cell IIII, IVI and IIIII. Despite these changes, the overall results of the residues showed that group I has higher resistance to decomposing than group II. As for the WS portions, the yields of the hydrolyzed and degraded products were higher in group II than group I, indicating that group II is less resistant to decomposition by HCW treatment. Results for both the residues and WS portions are in agreement with each other, showing that the degree of difficulty of decomposition was higher in group I than group II. Therefore, the decomposition behaviors of the celluloses are due to differences in the crystalline forms. 相似文献
73.
Malik Abdul Rub Dileep Kumar Naved Azum Farah Khan Abdullah M. Asiri 《Journal of solution chemistry》2014,43(5):930-949
In the present paper, the micellization of an amphiphilic drug, promazine hydrochloride, and gemini surfactants (16-s-16) with s = 4–6 and the monomeric hexadecyltrimethylammonium bromide (CTAB) counterparts has been examined conductometrically in the pure and mixed states in aqueous solutions at different compositions and temperatures (298.15–308.15 K). Dicationic gemini surfactants provide much better environment for the micellization behavior than the corresponding monocationic counterpart CTAB. The critical micelle concentration (cmc) values are lower than the cmc for ideal mixing, cmc id, suggesting attractive interactions between the two components in mixed micelles. The micellar mole fractions of surfactants, evaluated by different models, show greater contributions of surfactants in mixed micelles and increase with increasing concentrations of these surfactants. The negative values of β suggest synergism in the mixtures, which is highly beneficial as it reduces the total amount of surfactants required in a particular application, leading to reductions of cost and environmental impact. Activity coefficients (f 1 and f 2) are always less than unity showing nonideality in the systems. The data have been also used for evaluation of thermodynamic parameters. 相似文献
74.
The N-arylation of indoles with a variety of aryl bromides is reported using copper oxide nanoparticles as a heterogeneous catalyst. These copper oxide nanoparticles, which were produced in a novel, facile, and scalable fashion via an electrospinning technique, resulted in an excellent product yield under mild conditions. Moreover, the catalyst was easily recovered and reused several times without significant loss of activity. 相似文献
75.
K. F. Hassan S. Spellerberg B. Scholten Z. A. Saleh S. M. Qaim 《Journal of Radioanalytical and Nuclear Chemistry》2014,302(1):689-694
A novel anion-exchange chromatographic method for separation of radioiodine from an antimony target irradiated with 3He- or α-particles was developed, with separation yield of radioiodine amounting to 90 ± 5 % and its decontamination factor from the Te and Sb radionuclides to ~104. The optimized separation method developed was then applied to the production of 124I via the 121Sb(α,n)124I process using a highly enriched 121Sb target. Quality control tests showed that the separated 124I occurred >99 % as iodide and the longer lived impurities 126I and 125I amounted to 0.16 % and <0.05 %, respectively. The trace level of inactive Sb impurity was determined by ICP–OES. 相似文献
76.
Oil refinery is one of the fast growing industries across the globe and it is expected to progress in the near future. The worldwide increase in the generation of refinery wastewater along with strict environmental regulations in the discharge of industrial effluent, persistent efforts have been devoted to recycle and reuse the treated water. The wastewater from the refining operation leads to serious environmental threat to the ecosystem. Therefore, this study aimed to synthesize silica (SiO2) and calcium carbonate nanoparticles (CaCO3) in the reduction of organics from refinery wastewater. The synthesized nanoparticles were employed in the reduction of chemical oxygen demand (COD) from refinery wastewater by studying the influence of solution pH, contact time, dosage of nanoparticles and stirring speed on adsorption performance. From the batch experimental studies, the optimized processing conditions for the reduction of COD using SiO2 nanoparticles are pH 4.0, dosage 0.5 g, stirring speed 125 rpm and 90 min stirring time, and the corresponding values for CaCO3 nanoparticles are pH 8.0, dosage 0.4 g, stirring speed 100 rpm and 90 min stirring time. The study demonstrates that SiO2 and CaCO3 nanoparticles have a promising future in the reduction organics from refinery wastewater in different pH regimes. 相似文献
77.
Dongseok Kim Dr. Rosemary L. Calabro Abdullah A. Masud Nadeesha L. Kothalawala Dr. Minsu Gu Dr. Seung-Yeon Kwak Won-Joon Son Dr. Kyu Young Hwang Dr. Hyeonho Choi Prof. Christopher I. Richards Prof. Doo Young Kim Prof. Byeong-Su Kim 《化学:亚洲杂志》2021,16(24):4155-4164
Fluorescent carbon nanodots (CDs) have been highlighted as promising semiconducting materials due to their outstanding chemical and optical properties. However, the intrinsic heterogeneity of CDs has impeded a clear understanding of the mechanisms behind their photophysical properties. In this study, as-prepared CDs are fractionated via chromatography to reduce their structural and chemical heterogeneity and analyzed through ensemble and single-particle spectroscopies. Many single particles reveal fluorescence intensity fluctuations between two or more discrete levels with bi-exponential decays. While the intrinsic τ1 components are uniform among single particles, the τ2 components from molecule-like emissions spans a wider range of lifetimes, reflecting the inhomogeneity of the surface states. Furthermore, it is concluded that the relative population and chemical states of surface functional groups in CDs have a significant impact on emissive states, brightness, blinking, stability, and lifetime distribution of photoluminescence. 相似文献
78.
Mohammad A. Alzohairy Amjad Ali Khan Mohammed A. Alsahli Saleh A. Almatroodi Arshad Husain Rahmani 《Molecules (Basel, Switzerland)》2021,26(11)
Benzopyrene [B(a)P] is a well-recognized environmental carcinogen, which promotes oxidative stress, inflammation, and other metabolic complications. In the current study, the therapeutic effects of thymoquinone (TQ) against B(a)P-induced lung injury in experimental rats were examined. B(a)P used at 50 mg/kg b.w. induced lung injury that was investigated via the evaluation of lipid profile, inflammatory markers, nitric oxide (NO), and malondialdehyde (MDA) levels. B(a)P also led to a decrease in superoxide dismutase (SOD) (34.3 vs. 58.5 U/mg protein), glutathione peroxidase (GPx) (42.4 vs. 72.8 U/mg protein), catalase (CAT) (21.2 vs. 30.5 U/mg protein), and total antioxidant capacity compared to normal animals. Treatment with TQ, used at 50 mg/kg b.w., led to a significant reduction in triglycerides (TG) (196.2 vs. 233.7 mg/dL), total cholesterol (TC) (107.2 vs. 129.3 mg/dL), and inflammatory markers and increased the antioxidant enzyme level in comparison with the group that was administered B(a)P only (p < 0.05). B(a)P administration led to the thickening of lung epithelium, increased inflammatory cell infiltration, damaged lung tissue architecture, and led to accumulation of collagen fibres as studied through haematoxylin and eosin (H&E), Sirius red, and Masson’s trichrome staining. Moreover, the recognition of apoptotic nuclei and expression pattern of NF-κB were evaluated through the TUNEL assay and immunohistochemistry, respectively. The histopathological changes were found to be considerably low in the TQ-treated animal group. The TUNEL-positive cells increased significantly in the B(a)P-induced group, whereas the TQ-treated group showed a decreased apoptosis rate. Significantly high cytoplasmic expression of NF-κB in the B(a)P-induced group was seen, and this expression was prominently reduced in the TQ-treated group. Our results suggest that TQ can be used in the protection against benzopyrene-caused lung injury. 相似文献
79.
Saleh S. Alarfaji Ismat H. Ali Mutasem Z. Bani-Fwaz Mahmoud A. Bedair 《Molecules (Basel, Switzerland)》2021,26(11)
Despite the extensive use of carbon steel in all industrial sectors, particularly in the petroleum industry, its low corrosion resistance is an ongoing problem for these industries. In the current work, two malonyl dihydrazide derivatives, namely 2,2’-malonylbis (N-phenylhydrazine-1-carbothiamide (MBC) and N’1, N’3-bis(-2-hydroxybenzylidene) malonohydrazide (HBM), were examined as inhibitors for the carbon steel corrosion in 1.0 M HCl. Both MBC and HBM were characterised using thin-layer chromatography, elemental analysis, infrared spectroscopy, and nuclear magnetic resonance techniques. The corrosion tests were performed using mass loss measurements, polarisation curves, and electrochemical impedance spectroscopy. It is obtained from the mass loss studies that the optimal concentration for both inhibitors is 2.0 × 10−5 mol/L, and the inhibition efficiencies reached up to 90.7% and 84.5% for MBC and HBM, respectively. Electrochemical impedance spectroscopy (EIS) and potentiodynamic polarisation (PDP) indicate an increased impedance in the presence of both MBC and HBM and mixed-type inhibitors, respectively. Both inhibitors can mitigate corrosion in the range of 298–328 K. Values of free energy changes obtained from the Langmuir model suggest that the inhibitors suppress the corrosion process principally by chemisorption. The computational investigations were conducted to identify the factors connected with the anti-corrosive properties of the examined inhibitors. 相似文献
80.
Nada Abdullah Yahya Tamimi Sergey Dobretsov Najwa Al Balushi Jalila Alshekaili Hamed Al Balushi Mahmood Al Kindi Syed Imran Hassan Shadia Al Bahlani Benjamin K. Tsang Ikram A. Burney 《Molecules (Basel, Switzerland)》2021,26(12)
High-grade epithelial ovarian cancer is a fatal disease in women frequently associated with drug resistance and poor outcomes. We previously demonstrated that a marine-derived compound MalforminA1 (MA1) was cytotoxic for the breast cancer cell line MCF-7. In this study, we aimed to examine the effect of MA1 on human ovarian cancer cells. The potential cytotoxicity of MA1was tested on cisplatin-sensitive (A2780S) and cisplatin-resistant (A2780CP) ovarian cancer cell lines using AlamarBlue assay, Hoechst dye, flow cytometry, Western blot, and RT-qPCR. MA1 had higher cytotoxic activity on A2780S (IC50 = 0.23 µM) and A2780CP (IC50 = 0.34 µM) cell lines when compared to cisplatin (IC50 = 31.4 µM and 76.9 µM, respectively). Flow cytometry analysis confirmed the cytotoxic effect of MA1. The synergistic effect of the two drugs was obvious, since only 13% of A2780S and 7% of A2780CP cells remained alive after 24 h of treatment with both MA1 and cisplatin. Moreover, we examined the expression of bcl2, p53, caspase3/9 genes at RNA and protein levels using RT-qPCR and Western blot, respectively, to figure out the cell death mechanism induced by MA1. A significant down-regulation in bcl2 and p53 genes was observed in treated cells compared to non-treated cells (p < 0.05), suggesting that MA1 may not follow the canonical pathway to induce apoptosis in ovarian cancer cell lines. MalforminA1 showed promising anticancer activity by inducing cytotoxicity in cisplatin-sensitive and cisplatin-resistant cancer cell lines. Interestingly, a synergistic effect was observed when MA1 was combined with cisplatin, leading to it overcoming its resistance to cisplatin. 相似文献