The isolation and structure determination of cryptomisrine,a novel indolo[3,2-b]quinoline dimeric alkaloid from cryptolepis sanguinolenta

The isolation and structure determination of cryptomisrine, a novel indolo[3,2-b]quinoline dimeric alkaloid obtained from extracts of the roots of the Ghanaian medicinal plant Cryptolepis sanguinolenta is reported. The structure determination was made via a consideration of the spectral data, including uv, ir, nmr, and mass spectra. In particular, one-dimensional proton/carbon nmr, one-dimensional nOe difference nmr, and a series of homonuclear (COSY) and inverse-detected heteronuclear two-dimensional (HMQC, HMBC) experiments were utilized, as well as high resolution FABMS. Cryptomisrine is most unusual in that its two monomeric parts apparently exist in such a C₂ symmetric environment that only one set of proton and carbon nmr resonances are observed. Cryptomisrine is the first example of a dimeric indolo-[3,2-b]quinoline alkaloid to have been isolated from nature.     

Synthesis of novel tetracyclic chromenes through carbanion chemistry of 4-methyl coumarins

Various substituents were introduced onto the methyl group in 4-methyl coumarins through lithiation, followed by reactions with a wide range of electrophiles. The presence of an alkoxy group on 6′-phenyl ring was found to be pivotal for the success of this reaction. This procedure provided a convenient synthetic pathway to elaborate the methyl group of 4-methylcoumarins. Application of this methodology was showcased with the synthesis of biologically important novel tetracyclic chromene ring systems (n = 1-3).     

Cyclopolymerisation. 3. Mitt. ESR-Untersuchungen von Diallylaminen mit Redox-Systemen

Ohne Zusammenfassung     

Efficient preparation of enantiomerically pure cyclic aminoalditols,total synthesis of 1-deoxynojirimycin and 1-deoxymannojirimycyn

Expeditious new syntheses of the title compounds, which are potent glycosidase inhibitors, have been developed based on a high-yield, ring-forming aminomecuration.     

Inverted and suppressed direct response HMQC-TOCSY spectra - a convenient method of spectral editing

HMQC-TOCSY spectra provide a convenient means of establishing proton-proton connectivities in congested spectra of complex aromatic heterocycles. Advantage is taken of the greater dispersion of the ¹³C nmr spectrum to circumvent overlap which would preclude spectral interpretation through the usual COSY spectrum. A recently reported method for inverting direct responses (IDR) in HMQC-TOCSY spectra is demonstrated for [1]benzothieno[2,3-c]naphtho[2,1-g]quinoline. A modification of the IDR-HMQC-TOCSY method is also demonstrated which is capable of fully suppressing direct responses (SDR) without resorting to the timing of the onset of decoupling as in the original report of the HMQC-TOCSY experiment. SDR-HMQC-TOCSY has the further advantage of allowing the use of higher levels of digitization in F₂ than can be attained when broadband heteronuclear decoupling is employed.     

Collapse transition and asymptotic scaling behavior of lattice animals: Low-temperature expansion

A low-temperature expansion for the free energy density of lattice animals is derived. Analysis of the series yields a collapse transition temperature ofT _c - 0.54, in close agreement with previous estimates. It is demonstrated that _p,k, the number ofp-particle,p-bond animals, obeys the asymptotic scaling law log _p,k pg(k/p) + o(p). The low-temperature series and numerical data are used to estimate the scaling function.