On the linearity of ω-primality in numerical monoids

In an atomic, cancellative, commutative monoid, the ω-value measures how far an element is from being prime. In numerical monoids, we show that this invariant exhibits eventual quasilinearity (i.e., periodic linearity). We apply this result to describe the asymptotic behavior of the ω-function for a general numerical monoid and give an explicit formula when the monoid has embedding dimension 2.     

Differential characters and cohomology of the moduli of flat connections

Let \(\pi {:}\, P\rightarrow M\) be a principal bundle and p an invariant polynomial of degree r on the Lie algebra of the structure group. The theory of Chern–Simons differential characters is exploited to define a homology map \(\chi ^{k} {:}\, H_{2r-k-1}(M)\times H_{k}({\mathcal {F}}/{\mathcal {G}})\rightarrow {\mathbb {R}}/{\mathbb {Z}}\), for \(k<r-1\), where \({\mathcal {F}} /{\mathcal {G}}\) is the moduli space of flat connections of \(\pi \) under the action of a subgroup \({\mathcal {G}}\) of the gauge group. The differential characters of first order are related to the Dijkgraaf–Witten action for Chern–Simons theory. The second-order characters are interpreted geometrically as the holonomy of a connection in a line bundle over \({\mathcal {F}}/{\mathcal {G}}\). The relationship with other constructions in the literature is also analyzed.

     

Multiplexed therapeutic drug monitoring of antipsychotics in dried plasma spots by LC‐MS/MS

In this work, a convenient method for the therapeutic monitoring of seven common antipsychotic drugs in “dried plasma spot” samples has been developed. It is based on the liquid chromatography tandem mass spectrometry technique, operating in multiple reaction monitoring mode, and a straightforward procedure for the simultaneous extraction of all antipsychotics in a single step, with high extraction yield. The method was fully validated with proper accuracy, precision, selectivity and sensitivity, for all the drugs. Limits of quantification were 0.12, 1.09, 1.46, 1.47, 5.70, 1.32, 1.33 µg/L for haloperidol, aripiprazole, olanzapine, quetiapine, clozapine, risperidone, and paliperidone, respectively. Accuracy, intra‐ and interday precision values were <10% for all drugs at all concentration levels examined. The method was tested in the analysis of 30 plasma samples from real patients for each drug. The proposed analytical approach, by combining practical and logistical advantages of microsampling with liquid chromatography tandem mass spectrometry analytical performance, could offer an ideal strategy for accurate and timely therapeutic drug monitoring of antipsychotic drugs in most clinical settings, even in remote centers and/or in out‐patient settings, bringing so many potential improvements in psychiatric patient care.     

Artificial neural network for aspect ratio prediction of lignocellulosic micro/nanofibers

Cellulose - In this work a wide sample analysis, under similar conditions, has been carried out and a calibration strategy based on a careful selection of input variables combined with sensitivity...