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991.
利用碳酸钙作为处理模板,通过共沉淀联合水热法,制备了硒元素掺杂羟基磷灰石微球(HASe),期望硒掺杂能提高HA对溶菌酶的加载,并增强HASe微球的杀菌活性。所合成的HASe微球经SEM、TEM、DLS、XRD、FTIR和TGA测试对其理化性能进行了表征。并且利用姜黄素作为模式药物,评估了它们的药物加载及控释效能。结果发现,所合成的HASe产物为直径约1.0μm的球体,球壁粘附有许多羟基磷灰石纳米棒(长约150 nm﹑宽约20 nm)。该HASe微球对姜黄素具有高的药物加载和缓慢稳定的控释效应。其药物加载量为(88.72±0.01)mg·g~(-1),在0~159 h内仅有不到1.5 mg的姜黄素被释放,且无爆释现象。此外,还通过血液分析和细胞实验评估了HASe微球的毒性行为。与无硒HA微球相比,HASe微球的血液毒性低,对细胞损伤少,然而对骨肉瘤细胞生长却具有强的抑制作用。 相似文献
992.
993.
Systematic characterization of the metabolites of echinacoside and acteoside from Cistanche tubulosa in rat plasma,bile, urine and feces based on UPLC‐ESI‐Q‐TOF‐MS 下载免费PDF全文
Qingling Cui Yingni Pan Xuewei Bai Wei Zhang Lixia Chen Xiaoqiu Liu 《Biomedical chromatography : BMC》2016,30(9):1406-1415
Echinacoside (ECH) and acteoside (ACT), as the most and major active components of Cistanche tubulosa, were reported to possess cardioactive, neuroprotective and hepatocyte protective effects, as well as antibacterial, antioxidative effects. Recently, more studies have focused on their pharmacological activities. However, their metabolic profiles in vivo have not been sufficiently investigated. This study proposes an approach for rapidly identifying the complicated and unpredictable metabolites of ECH and ACT in rat plasma, bile, urine and feces, and systematically and comprehensively revealing their major metabolic pathways, based on powerful ultra‐high performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry. Plasma, bile, urine and feces were collected from rats after a single 200 mg/kg oral dose. A total of 49 metabolites were detected in rat biological samples. Through analyzing metabolites in bile samples, it was found that ECH and ACT were subjected to a marked hepatic first‐pass effect in liver. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
994.
Formation of Fluorinated Amido Esters through Unexpected C3−C4 Bond Fission in 4‐Trifluoromethyl‐3‐oxo‐β‐lactams 下载免费PDF全文
Hang Dao Thi Dr. Hannelore Goossens Dr. Dietmar Hertsen Valerie Otte Prof. Dr. Tuyen Van Nguyen Prof. Dr. Veronique Van Speybroeck Prof. Dr. Matthias D'hooghe 《化学:亚洲杂志》2018,13(4):421-431
4‐Trifluoromethyl‐3‐oxo‐β‐lactams were unexpectedly transformed into 2‐[(2,2‐difluorovinyl)amino]‐2‐oxoacetates as major products, accompanied by minor amounts of 2‐oxo‐2‐[(2,2,2‐trifluoroethyl)amino]acetates, upon treatment with alkyl halides and triethylamine in DMSO. This peculiar C3?C4 bond fission reactivity was investigated in‐depth, from both an experimental and a computational point of view, in order to shed light on the underlying reaction mechanism. 相似文献
995.
The Utilization of Amide Groups to Expand and Functionalize Metal‐Organic Frameworks Simultaneously 下载免费PDF全文
Dr. Zhiyong Lu Prof. Dr. Junfeng Bai Cheng Hang Fei Meng Prof. Dr. Wenlong Liu Prof. Dr. Yi Pan Prof. Dr. Xiaozeng You 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(18):6129-6129
Invited for the cover of this issue is the group of Junfeng Bai at Nanjing University. The image depicts how to obtain mesoporosity in MOFs by ligand extension with amide spacers. Read the full text of the article at 10.1002/chem.201504907 . 相似文献
996.
In this paper, impulsive synchronization of drive-response complex-variable chaotic systems is investigated. The drive-response systems with known parameters is considered via impulsive control and adaptive scheme as well as systems with unknown parameters. Noticeably, adaptive strategy is adopted to relax the restriction on the impulsive interval, and the system parameters need not to be known beforehand. According to the Lyapunov stability theory, some synchronization criteria are derived and verified by several numerical simulations. 相似文献
997.
998.
We establish a necessary and sufficient topological condition for maps that are in W1,p(M, N) to be connected by continuous paths in W1,p(M, N) to maps in W1,q(M, N), q > q ≥ 1. We also obtain a necessary and sufficient topological condition under which W1,q(M, N) is strongly dense in W1,p(M, N). Several results concerning sequential weak density of smooth (or W1,q(M, N) maps in W1,p(M, N) are also proven. © 2003 Wiley Periodicals, Inc. 相似文献
999.
本文应用束传播与重叠积分方法,考虑输入波导区、耦合区和输出波导区整体结构,提出了方向耦合器结构参量的新型设计方法.与耦合模及局部模等方法相比,该方法具有计算简便,结果精确等优点. 相似文献
1000.
Directed minimum cost spanning tree problems of a special kind are studied, namely those which show up in considering the
problem of connecting units (houses) in mountains with a purifier. For such problems an easy method is described to obtain
a minimum cost spanning tree. The related cost sharing problem is tackled by considering the corresponding cooperative cost
game with the units as players and also the related connection games, for each unit one. The cores of the connection games
have a simple structure and each core element can be extended to a population monotonic allocation scheme (pmas) and also
to a bi-monotonic allocation scheme. These pmas-es for the connection games result in pmas-es for the cost game. 相似文献