Synthesis, antitumor and DNA photocleaving activities of novel naphthalene carboxamides: effects of different thio-heterocyclic rings and aminoalkyl side chains

Two kinds of thio-heterocyclic fused naphthalene carboxamides, 3a-b, 4a-b, were designed, synthesized and quantitatively evaluated as efficient antitumor and DNA photocleaving agents. Compound 3a or 3b, having the thiophene ring, intercalated into DNA more strongly than compound 4a or 4b, having the thioxanthene ring. Compound 4a or 4b, photocleaved DNA more efficiently than 3a or 3b via superoxide anion. Compound 4a was the strongest inhibitor for P388 (murine leukemia cell), while 3a was the most cytotoxic one against A549 (human lung cancer cell). Each new compound showed stronger DNA photocleaving activity than corresponding naphthalimide.     

全硅FER沸石上有机吸附物脱附行为的研究

运用热分析技术,研究吸附在体相和表面结构完美的单晶状疏水全硅FER沸石孔道中的有机化合物的脱附行为,测定亲和性指数AT值和负载量。所研究的吸附质为直链烷烃、直链烷基醇、直链烷基胺等,结果显示醇有较低的AT值,而直链烷烃有较高的AT值,胺类有最高的AT值。证明全硅FER沸石骨架对烷基、胺基呈现出强的"亲和性",而对羟基呈现出“憎性”。同时还发现吸附质的链长对脱附性质、AT值也有较大影响。     

Tweezer分子的合成和对有机阴离子的配位效应

本文报道新的Ｔｗｅｅｚｅｒ（１）的合成，用＾１ＨＮＭＲ研究了新的Ｔｗｅｅｚｅｒ分子和对硝基苯甲酸盐的配位效应，结果表明它兴通过氢键，静电引力和芳环夹心堆叠作用而自动缔合。     

Four new triterpene glycosides from Thalictrum squarrosum

Four new triterpene glycosides were isolated from the dried aerial parts of Thalictrum squarrosum (Ranunculaceae). They were designated as squarroside I, being a cycloartane-type glycoside, and squarrosides II, III and IV, being oleanene-type glycosides. Their structures were established by using two dimensional (2D) NMR techniques.     

Separation, identification, and interaction of heparin oligosaccharides with granulocyte-colony stimulating factor using capillary electrophoresis and mass spectrometry

A capillary electrophoresis (CE) method was developed for the separation of heparin oligosaccharides compatible to study the interactions between the oligosaccharides and granulocyte-colony stimulating factor (G-CSF). Unfractionated heparin was eliminitively degraded to heparin oligosaccharides by an endolytic heparinase. The degraded smaller oligosaccharides (M(r) < 1000) were baseline-separated by CE under a 50 mM phosphate buffer (pH 9.0) in 10 min. Standard heparin disaccharides and larger oligosaccharides (1000 < M(r) < 8000) were all separated under optimized separation conditions. Compared with standard heparin disaccharides, smaller oligosaccharides contained one nonsulfated, two monosulfated, and two disulfated disaccharides, but trisulfated disaccharides were not found. The smaller oligosaccharides were also identified and molecular mass was deduced by electrospray ionization-mass spectrometry (ESI-MS). Furthermore, interactions between G-CSF and the oligosaccharides were studied by using capillary zone electrophoresis (CZE) under the above separation conditions. It was found that larger oligosaccharides could interact with G-CSF while smaller oligosaccharides were not observed to bind to G-CSF under the experimental conditions. In conclusion, the purified heparinase could selectively degrade heparin into oligosaccharides and the interaction between G-CSF and heparin was correlated with the chain length of heparin.     

Baker''''s yeast mediated reduction of substituted acenaphthenequinones: Regio-and enantioselective preparation of mono-hydroxyacenaphthenones

Baker's yeast mediated reduction of acenaphthenequinone within 4-10 h afforded mono-hydroxyacenaphthenone mainly with low enantioselectivity, the substrate and mono-hydroxyacenaphthenone product almost converted to dihydroxyacenaphthene after 48 h. By control of the reaction time and in the presence of DMF as co-solvent, the reduction of 6-substituted acenaphthenequinones under vigorous agitation afforded the corresponding 2-hydroxyacenaphthenones in 24-84% yields with 10-93% ee.     

Rearrangement of phenylethenes on reaction with iodine-xenon difluoride

Phenyl-substituted ethenes react with iodine and xenon difluoride to provide difluorinated products. Iodofluoro intermediates react with xenon difluoride to produce transient iodine difluoride species that lose IF and F(-) and produce carbocations.     

老年人彩度对比敏感度函数研究及滤波应用

为研究老年人彩色视觉频率响应特性，获取彩度对比敏感度与空间频率之间的函数关系，本文在LCH均匀颜色空间基础上，固定明度和色调角值，以彩度作为变量，设计人眼彩度对比敏感度实验，进行人眼视觉观察实验。获得彩度对比敏感度与空间频率的关系，并构建指数型对比敏感度函数模型。经分析表明老年人眼彩度对比敏感度随着空间频率的增加，产生先升高再缓慢降低的变化，各色调角下彩度对比度存在差异。经分析人眼对比敏感度差异与人眼视觉辨色特性有很大的相关性。并且，将构建的对比敏感度函数模型用于实现基于人眼视觉系统的滤波处理。     

Cover Picture: A Stepwise Annulation for the Transformation of Cyclic Ketones to Fused 6 and 7‐Membered Cyclic Enimines and Enones (Chin. J. Chem. 4/2019)

The cover picture shows a typical building within the Campus of Xiamen University displaying Chen Jiageng (Tan Kah Kee)'s style. Just like many beautiful buildings designed and constructed by human, Nature “designs and constructs” a huge number of useful molecules with fascinating structures called natural products. Many natural products possess a fused six or seven‐membered carbocyclic unity. On page 315–322, the Huang's group disclosed a three‐step “[2+n]” annulation method for the construction of fused six and seven‐membered carbocyclic enimines and enones. The method starts from simple cyclic ketones and terminal olefinic amides, and relies on both the Suzuki coupling reaction and the olefin‐amide based Friedel‐Crafts type acylating reaction, a method developed by Huang and coworkers.

     

MoO3、NiO、ZnO在小表面金红石上的分散行为

Dispersion of MoO3, NiO, ZnO on rutile TiO2 with low specific surface area was studied with Mercury Porosimeter, SEM, XPS and Ammonia Extraction method. The dispersion thresholds of MoO3, NiO, ZnO on three rutile TiO2 carriers were obtained with XPS, and com-pared with those on anatase TiO2 with high specific surf are area. Ammonia Extraction method was used to identify the surface oxide species interarting with support surface in different strength and it was found that the proportions of oxides that can not be extracted by ammonia extraction are different for MoO3, NiO and ZnO which are supported on rutile TiO2.