全文获取类型
收费全文 | 230609篇 |
免费 | 4727篇 |
国内免费 | 3335篇 |
专业分类
化学 | 130549篇 |
晶体学 | 3349篇 |
力学 | 9502篇 |
综合类 | 210篇 |
数学 | 25650篇 |
物理学 | 69411篇 |
出版年
2021年 | 1937篇 |
2020年 | 2242篇 |
2019年 | 2374篇 |
2018年 | 2863篇 |
2017年 | 2937篇 |
2016年 | 4211篇 |
2015年 | 2998篇 |
2014年 | 4150篇 |
2013年 | 9707篇 |
2012年 | 8457篇 |
2011年 | 10244篇 |
2010年 | 7291篇 |
2009年 | 7053篇 |
2008年 | 9475篇 |
2007年 | 9461篇 |
2006年 | 8893篇 |
2005年 | 8172篇 |
2004年 | 7240篇 |
2003年 | 6377篇 |
2002年 | 6370篇 |
2001年 | 7007篇 |
2000年 | 5342篇 |
1999年 | 3901篇 |
1998年 | 3215篇 |
1997年 | 3136篇 |
1996年 | 3157篇 |
1995年 | 2727篇 |
1994年 | 2847篇 |
1993年 | 2680篇 |
1992年 | 2902篇 |
1991年 | 2985篇 |
1990年 | 2791篇 |
1989年 | 2654篇 |
1988年 | 2597篇 |
1987年 | 2526篇 |
1986年 | 2553篇 |
1985年 | 3333篇 |
1984年 | 3373篇 |
1983年 | 2822篇 |
1982年 | 3054篇 |
1981年 | 2818篇 |
1980年 | 2611篇 |
1979年 | 2792篇 |
1978年 | 2996篇 |
1977年 | 3032篇 |
1976年 | 3059篇 |
1975年 | 2793篇 |
1974年 | 2906篇 |
1973年 | 2956篇 |
1972年 | 2318篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
Daulbaev O. Isaenko L. I. Bogdzel’ A. A. Lobanov S. I. Krinitsyn P. G. Milkov V. M. Belushkin A. V. 《Crystallography Reports》2022,67(3):464-469
Crystallography Reports - Two LiInSe2 single crystals, grown under different conditions, have been studied. Characteristics of these crystals for neutron detection have been compared using... 相似文献
12.
Vasile M. Loots H. Vercammen L. Bruggeman M. Verrezen F. 《Journal of Radioanalytical and Nuclear Chemistry》2022,331(8):3349-3357
Journal of Radioanalytical and Nuclear Chemistry - In this paper a study for the selection of an NPE (nonylphenol ethoxylates)—free cocktail is discussed in order to be used for our routine... 相似文献
13.
Hongjin Wang Tengfei Long Hao Zhang Meng Li Qi Sun Xin Zhai Lixin Sun 《Biomedical chromatography : BMC》2022,36(4):e5301
3,4-Difluorobenzyl(1-ethyl-5-(4-((4-hydroxypiperidin-1-yl)-methyl)thiazol-2-yl)-1H-indol-3-yl)carbamate (NAI59), a small molecule with outstanding therapeutic effectiveness to anti-pulmonary fibrosis, was developed as an autotaxin inhibitor candidate compound. To evaluate the pharmacokinetics and plasma protein binding of NAI59, a UPLC–MS/MS method was developed to quantify NAI59 in plasma and phosphate-buffered saline. The calibration curve linearity ranged from 9.95 to 1990.00 ng/mL in plasma. The accuracy was −6.8 to 5.9%, and the intra- and inter-day precision was within 15%. The matrix effect and recovery, as well as dilution integrity, were within the criteria. The chromatographic and mass spectrometric conditions were also feasible to determine phosphate-buffered saline samples, and it has been proved that this method exhibits good precision and accuracy in the range of 9.95–497.50 ng/mL in phosphate-buffered saline. This study is the first to determine the pharmacokinetics, absolute bioavailability, and plasma protein binding of NAI59 in rats using this established method. Therefore, the pharmacokinetic profiles of NAI59 showed a dose-dependent relationship after oral administration, and the absolute bioavailability in rats was 6.3%. In addition, the results of protein binding showed that the combining capacity of NAI59 with plasma protein attained 90% and increased with the increase in drug concentration. 相似文献
14.
Ukrainian Mathematical Journal - We establish new criteria of compatibility for a linear system of equations (equivalent to the Kronecker–Capelli theorem) or inequalities (equivalent to the... 相似文献
15.
Restricted testing conditions were considered recently. For the maximal operator, Hytönen, Li and Sawyer [8] first obtained parental testing condition. Later, they [9] showed that it suffices to restrict testing to doubling cubes. Chen and Lacey [3] gave a similar restricted testing condition. In our paper, we discuss a version of the latter in the multilinear setting.
相似文献16.
Corinne Rondeau-Mouro Mireille Cambert Laurent Blondel Yves Diascorn Léo Mbaya Nor Nadiah Binti Ahmad Nazari Sarah Helary Tiphaine Lucas 《Magnetic resonance in chemistry : MRC》2022,60(7):678-691
A temperature control unit was implemented to vary the temperature of samples studied on a commercial Mobile Universal Surface Explorer nuclear magnetic resonance (MOUSE-NMR) apparatus. The device was miniaturized to fit the maximum MOUSE sampling depth (25 mm). It was constituted by a sample holder sandwiched between two heat exchangers placed below and above the sample. Air was chosen as the fluid to control the temperature at the bottom of the sample, at the interface between the NMR probe and the sample holder, in order to gain space. The upper surface of the sample was regulated by the circulation of water inside a second heat exchanger placed above the sample holder. The feasibility of using such a device was demonstrated first on pure water and then on several samples of bread dough with different water contents. For this, T1 relaxation times were measured at various temperatures and depths and were then compared with those acquired with a conventional compact closed-magnet spectrometer. Discussion of results was based on biochemical transformations in bread dough (starch gelatinization and gluten heat denaturation). It was demonstrated that, within a certain water level range, and because of the low magnetic field strength of the MOUSE, a linear relationship could be established between T1 relaxation times and the local temperature in the dough sample. 相似文献
17.
Chueshova A. G. Pavlova L. A. Peshcherova S. M. Nepomnyashchikh A. I. 《Crystallography Reports》2021,66(7):1206-1215
Crystallography Reports - The orientation of grains and the special boundaries formed by them in multicrystalline silicon has been studied by electron backscattered diffraction. It is found that... 相似文献
18.
Crystallography Reports - Methods of coherent X-ray diffraction imaging of the spatial structure of noncrystalline objects and nanocrystals (nanostructures) are considered. Particular attention is... 相似文献
19.
In a 2:2 reaction with silver(I) chloride or bromide, 1,5-bis(1-phospholano)pentane ( 1a ) afforded frame-like macrocyclic structures, with intra- ( 2 , Cl) or intermolecular ( 3 , Br) halido bridges. In contrast, 1,7-bis(1-phospholano)heptane ( 1b ) formed coordination polymers 4a (Cl) and 4b (Br) with bridging bis-phospholane and halido ligands. A unique paddle wheel-type metallacryptand structure 5 was obtained from 1a and silver(I) bromide in a 2:3 reaction (M:L). All complexes were fully characterized by NMR, IR spectroscopy, mass spectrometry, and X-ray crystallography. 相似文献
20.
Laurens Kooijman Dr. Matthias Schuster Christian Baumann Simon Jurt Dr. Frank Löhr Dr. Boris Fürtig Prof. Dr. Peter Güntert Prof. Dr. Oliver Zerbe 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(47):21151-21158
To achieve efficient proton pumping in the light-driven proton pump bacteriorhodopsin (bR), the protein must be tightly coupled to the retinal to rapidly convert retinal isomerization into protein structural rearrangements. Methyl group dynamics of bR embedded in lipid nanodiscs were determined in the dark-adapted state, and were found to be mostly well ordered at the cytosolic side. Methyl groups in the M145A mutant of bR, which displays only 10 % residual proton pumping activity, are less well ordered, suggesting a link between side-chain dynamics on the cytosolic side of the bR cavity and proton pumping activity. In addition, slow conformational exchange, attributed to low frequency motions of aromatic rings, was indirectly observed for residues on the extracellular side of the bR cavity. This may be related to reorganization of the water network. These observations provide a detailed picture of previously undescribed equilibrium dynamics on different time scales for ground-state bR. 相似文献