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61.
Du Y Mao K Kamakoti P Ravikovitch P Paur C Cundy S Li Q Calabro D 《Chemical communications (Cambridge, England)》2012,48(38):4606-4608
Pyridine-modified COF-10 exhibits enhanced stability in humid air relative to un-modified COF-10. Solid state NMR and computational studies were used to probe the nature of pyridine interactions with the framework. We propose two models for pyridine-framework interactions with different stabilities. 相似文献
62.
Preeti Saluja Hemant Sharma Navneet Kaur Narinder Singh Doo Ok Jang 《Tetrahedron》2012,68(10):2289-2293
We synthesized an imine-linked, benzimidazole-based chemosensor that can be used for chromogenic recognition of Mg2+ and fluorescent recognition of Cr3+. The chemosensor shows sensitive, selective, and ratiometric recognition of Cr3+ through concurrent quenching at one wavelength and enhancement of fluorescence intensity at another wavelength. It can also be used to detect Mg2+ via UV–vis absorption spectroscopy. DFT calculations support these phenomena. The sensor can be used to strain microbe cells without breakage. 相似文献
63.
A benzimidazole-based imine linked receptor was synthesized for fluorescent recognition of Cu2+ in a CH3CN/H2O (8:2, v/v) solvent system. The receptor offers an opportunity for the selective estimation of Cu2+ in the presence of another metal ion at equimolar concentration. The Cu2+ complex with the receptor acted as a sensor for a phosphate anion, and the phosphate recognition event restored the fluorescence intensity of the receptor. 相似文献
64.
P Iyer D Dimova M Vogt J Bajorath 《Journal of chemical information and modeling》2012,52(8):1962-1969
The transformation of high-dimensional bioactivity spaces into activity landscape representations is as of yet an unsolved problem in computational medicinal chemistry. High-dimensional activity spaces result from the experimental evaluation of compound sets on large numbers of targets. We introduce a first concept to represent and navigate high-dimensional activity landscapes that is based on a data structure termed ligand-target differentiation (LTD) map. This approach is designed to reduce the complexity of high-dimensional bioactivity spaces and enable the identification and further analysis of compound subsets with interesting activity and structural relationships. Its utility has been demonstrated using a set of more than 1400 inhibitors with exact activity measurements for varying numbers of 172 kinases. 相似文献
65.
Priyanka Garg Preeti Bhauriyal Dr. Arup Mahata Kuber Singh Rawat Dr. Biswarup Pathak 《Chemphyschem》2019,20(3):383-391
Using state-of-the-art density functional theoretical calculations, we have modelled a facetted CdS nanotube (NT) catalyst for photocatalytic water splitting. The overall photocatalytic activity of the CdS photocatalyst has been predicted based on the electronic structures, band edge alignment, and overpotential calculations. For comparisons, we have also investigated the water splitting process over bulk CdS. The band edge alignment along with the oxygen evolution reaction/hydrogen evolution reaction (OER/HER) mechanism studies help us find out the effective overpotential for the overall water splitting on these surfaces. Our study shows that the CdS NT has a highly stabilized valence band edge compared to that of bulk CdS owing to strong p–d mixing. The highly stabilized valence band edge is important for the hole-transfer process and reduces the risk of electron-hole recombination. CdS nanotube requires less overpotential for water oxidation reaction than the bulk CdS. Our findings suggest that the efficiency of the water oxidation/reduction process further improves in CdS as we reduce its dimensionality, that is going from bulk CdS to one-dimensional nanotube. Furthermore, the stabilized valence band edge of CdS nanotube also improves the photostability of CdS, which is a problem for bulk CdS. 相似文献
66.
Mazaahir Kidwai Preeti Misra Bhavesh Dave Kumar R. Bhushan Rajendra K. Saxena Meena Singh 《Monatshefte für Chemie / Chemical Monthly》2000,131(11):1207-1212
Summary. A novel synthesis of 6-fluoro-7-(5-aryl-1,3,4-thiadiazol/oxadiazol-2-yl-sulfanyl)-4-quinolone-3-carboxylic acids from 7-chloro-6-fluoro-4-quinolone-3-carboxylic
acid and 5-substituted 1,3,4-thiadiazoles/oxadiazoles on basic alumina under microwave activation is described. All compounds
were screened for their in vitro antibacterial activity against B. lichenformis, 2689, K. aerogens 2281, S. typhimurium 2501, E. herbicola 2491, and P. vulgaris 2027 and found to possess activities comparable to that of the standard drug norfloxacin.
Received May 2, 2000. Accepted (revised) June 13, 2000 相似文献
67.
Manju Solra Rohit Kapila Sourav Das Preeti Bhatt Dr. Subinoy Rana 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2024,136(15):e202400348
Dissipative supramolecular assemblies are hallmarks of living systems, contributing to their complex, dynamic structures and emerging functions. Living cells can spatiotemporally control diverse biochemical reactions in membrane compartments and condensates, regulating metabolite levels, signal transduction or remodeling of the cytoskeleton. Herein, we constructed membranous compartments using self-assembly of lipid-like amphiphiles (lipidoid) in aqueous medium. The new double-tailed lipidoid features Cu(II) coordinated with a tetravalent chelator that dictates the binding of two amphiphilic ligands in cis-orientation. Hydrophobic interactions between the lipidoids coupled with intermolecular hydrogen bonding led to a well-defined bilayer vesicle structure. Oil-soluble SNAr reaction is efficiently upregulated in the hydrophobic cavity, acting as a catalytic crucible. The modular system allows easy incorporation of exposed primary amine groups, which augments the catalysis of retro aldol and C−N bond formation reactions. Moreover, a higher-affinity chelator enables consumption of the Cu(II) template leveraging the differential thermodynamic stability, which allows a controllable lifetime of the vesicular assemblies. Concomitant temporal upregulation of the catalytic reactions could be tuned by the metal ion concentration. This work offers new possibilities for metal ion-mediated dynamic supramolecular systems, opening up a massive repertoire of functionally active dynamic “life-like” materials. 相似文献
68.
In this research work, both qualitative and quantitative measurement of biospeckle activity of three Indian fruits namely apple, pear and tomato have been carried out using Generalized Difference and Parameterized Fujii methods. Different activity area of the fruits can be easily visualized through the spectral maps. The variation of activity level of the fruits during shelf life storage has been studied through activity graphs. Comparative studies of activities of all the fruits are also presented and relatively high activity was found in apple compared to pear and tomato. 相似文献
69.
Analytical and numerical study of the stability of sheet electron beam in periodically cusped magnetic field (PCM) is made.
The beam has been considered as having diffused density profile. The conditions for beam focusing are discussed. 相似文献
70.
Prashant Jain Chethan D. Shanthamurthy Preeti Madhukar Chaudhary Raghavendra Kikkeri 《Chemical science》2021,12(11):4021
The aberrant expression of endocytic epidermal growth factor receptors (EGFRs) in cancer cells has emerged as a key target for therapeutic intervention. Here, we describe for the first time a state-of-the-art design for a heparan sulfate (HS) oligosaccharide-based nanovehicle to target EGFR-overexpressed cancer cells in cellular heterogeneity. An ELISA plate IC50 inhibition assay and surface plasma resonance (SPR) binding assay of structurally well-defined HS oligosaccharides showed that 6-O-sulfation (6-O-S) and 6-O-phosphorylation (6-O-P) of HS tetrasaccharides significantly enhanced EGFR cognate growth factor binding. The conjugation of these HS ligands to multivalent fluorescent gold nanoparticles (AuNPs) enabled the specific and efficient targeting of EGFR-overexpressed cancer cells. In addition, this heparinoid-nanovehicle exhibited selective homing to NPs in cancer cells in three-dimensional (3D) coculture spheroids, thus providing a novel target for cancer therapy and diagnostics in the tumor microenvironment (TME).Heparan sulfate oligosaccharide based nanovehicle greatly enhance the selective targeting of cancer cells in tumor microenvironment. 相似文献