含黄酮的三价铁配合物合成及其药理性质(英文)

3,3,4,7-四羟基黄酮与1,3-二环己基碳二亚胺在4-二甲胺吡啶存在下反应,得到2,2-双(3,3,4,7-四羟基黄酮)1,3-二环己基碳二亚胺。三价金属离子与上述合成得到的配体螯合,对此四面体结构的双核Fe(Ⅲ)配合物的血液学及病理学数据进行了讨论,同时研究了合成的配体作为螯合剂清除鼠肝胰组织中超载的铁的能力。结果表明作为口服药其作为双齿配体的螯合能力与市售用于治疗地中海贫血的药物"去铁敏"相近。     

Temperature and magnetic field responsive hyaluronic acid particles with tunable physical and chemical properties

We report the preparation and characterization of thiolated-temperature-responsive hyaluronic acid-cysteamine-N-isopropyl acrylamide (HA-CYs-NIPAm) particles and thiolated-magnetic-responsive hyaluronic acid (HA-Fe-CYs) particles. Linear hyaluronic acid (HA) crosslinked with divinyl sulfone as HA particles was prepared using a water-in-oil micro emulsion system which were then oxidized HA-O with NaIO₄ to develop aldehyde groups on the particle surface_. HA-O hydrogel particles were then reacted with cysteamine (CYs) which interacted with aldehydes on the HA surface to form HA particles with cysteamine (HA-CYs) functionality on the surface. HA-CYs particles were further exposed to radical polymerization with NIPAm to obtain temperature responsive HA-CYs-NIPAm hydrogel particles. To acquire magnetic field responsive HA composites, magnetic iron particles were included in HA to form HA-Fe during HA particle preparation. HA-Fe hydrogel particles were also chemically modified. The prepared HA-CYs-NIPAm demonstrated temperature dependent size variations and phase transition temperature. HA-CYs-NIPAm and HA-Fe-CYs particles can be used as drug delivery vehicles. Sulfamethoxazole (SMZ), an antibacterial drug, was used as a model drug for temperature-induced release studies from these particles.     

Synthesis and characterization of nanomagnetite particles and their polymer coated forms

Superparamagnetic nanoparticles were prepared by coprecipitation of ferrous (Fe(2+)) and ferric (Fe(3+)) aqueous solution by a base. Nanomagnetite particles were coated with poly(St/PEG-EEM/DMAPM) and poly(St/PEG-MA/DMAPM) layer by emulsifier-free emulsion polymerization. Chemical structure of nanoparticles was characterized by both FTIR and (1)H NMR. Particle morphologies were determined by Zeta Sizer, DLS, XRD and SAXS. Structural analysis showed that after polymer coating nanomagnetite particles kept their superparamagnetic property. Besides the synthesized magnetites, polymer coated forms of these particles are more biocompatible, well dispersable and uniform. These properties make them a very strong candidate for bioengineering applications, such as bioseparation, gene transfer.     

Polyfluorinated cycloalkoxyphenyl ether systems as dopants for liquid crystal display applications

The effects on response times of representative commercially available dielectrically negative (−LC) and positive (+LC) type liquid crystal mixtures doped with small quantities of various tetrafluorinated cycloalkoxyphenyl ether derivatives were investigated. The synthesis of various polyfluoroaryl systems by nucleophilic aromatic substitution processes is described and electro-optical measurements concerning the rise and decay times and voltage holding ratios of each doped LC formulation are reported. The response time of the dielectrically negative LC host was improved upon doping with each of the tetrafluorinated cycloalkoxyphenyl ether derivatives, although no improvement in the performance of the dielectrically positive LC host was achieved.     

Optimal broadcast domination in polynomial time

Broadcast domination was introduced by Erwin in 2002, and it is a variant of the standard dominating set problem, such that different vertices can be assigned different domination powers. Broadcast domination assigns an integer power f(v)?0 to each vertex v of a given graph, such that every vertex of the graph is within distance f(v) from some vertex v having f(v)?1. The optimal broadcast domination problem seeks to minimize the sum of the powers assigned to the vertices of the graph. Since the presentation of this problem its computational complexity has been open, and the general belief has been that it might be NP-hard. In this paper, we show that optimal broadcast domination is actually in P, and we give a polynomial time algorithm for solving the problem on arbitrary graphs, using a non-standard approach.     

A penalty continuation method for the ∓∞ solution of overdetermined linear systems

A new algorithm for the ∓_∞ solution of overdetermined linear systems is given. The algorithm is based on the application of quadratic penalty functions to a primal linear programming formulation of the ∓_∞ problem. The minimizers of the quadratic penalty function generate piecewise-linear non-interior paths to the set of ∓_∞ solutions. It is shown that the entire set of ∓_∞ solutions is obtained from the paths for sufficiently small values of a scalar parameter. This leads to a finite penalty/continuation algorithm for ∓_∞ problems. The algorithm is implemented and extensively tested using random and function approximation problems. Comparisons with the Barrodale-Phillips simplex based algorithm and the more recent predictor-corrector primal-dual interior point algorithm are given. The results indicate that the new algorithm shows a promising performance on random (non-function approximation) problems.     

A unified Monte Carlo treatment of the transport of electromagnetic energy, electrons, and phonons in absorbing and scattering media

The scalar Boltzmann transport equation (BTE) is often applicable to radiative energy transfer, electron-beam propagation, as well as thermal conduction by electrons and phonons provided that the characteristic length of the system is much larger than the wavelength of energy carriers and that certain interference phenomena and the polarization nature of carriers are ignored. It is generally difficult to solve the BTE analytically unless a series of assumptions are introduced for the particle distribution function and scattering terms. Yet, the BTE can be solved using statistical approaches such as Monte Carlo (MC) methods without simplifying the underlying physics significantly. Derivations of the MC methods are relatively straightforward and their implementation can be achieved with little effort; they are also quite powerful in accounting for complicated physical situations and geometries. MC simulations in radiative transfer, electron-beam propagation, and thermal conduction by electrons and phonons have similar simulation procedures; however, there are important differences in implementing the algorithms and scattering properties between these simulations. The objective of this review article is to present these simulation procedures in detail and to show that it is possible to adapt an existing MC computer code, for instance, in radiative transfer, to account for physics in electron-beam transport or phonon (or electronic thermal) conduction by sorting out the differences and implementing the correct corresponding steps. Several simulation results are presented and some of the difficulties associated with different applications are explained.     

Effect of Cd/Te ratio on the formation of CdTe magic-sized quantum dots during aggregation

In this study, the aggregation dynamics of magic-sized CdTe quantum dots is investigated. The experiments show that the growth kinetics of the quantum dots is very sensitive to the Cd/Te ratio. The crossover from tellurium-rich to cadmium-rich conditions produces a very different aggregation pattern, which can be explained by the lack of formation of magic-sized nanoparticles during the reaction conditions. A simple simulation that includes both monomer-induced growth and aggregation growth is presented to reproduce the experimentally observed aggregation patterns. The simulation results strongly suggest that the experimental aggregation pattern can be reproduced if initially a double magic-sized distribution is assumed. The numerical data clearly show that the aggregation is enhanced by the dipole-dipole interaction. Simulations also suggest that the neck formation of the CdTe quantum dot aggregates is unlikely under the experimental conditions. The absence of neck formation is in agreement with the expectations during high-temperature synthesis.