The effect of linear perturbations on the Yamabe problem

In conformal geometry, the Compactness Conjecture asserts that the set of Yamabe metrics on a smooth, compact, aspherical Riemannian manifold $\left( M,g\right) $ is compact. Established in the locally conformally flat case by Schoen (Lecture Notes in Mathematics, vol. 1365, pp. 120–154. Springer, Berlin 1989, Surveys Pure Application and Mathematics, 52 Longman Science, Technology, pp. 311–320. Harlow 1991) and for $n\le 24$ by Khuri–Marques–Schoen (J Differ Geom 81(1):143–196, 2009), it has revealed to be generally false for $n\ge 25$ as shown by Brendle (J Am Math Soc 21(4):951–979, 2008) and Brendle–Marques (J Differ Geom 81(2):225–250, 2009). A stronger version of it, the compactness under perturbations of the Yamabe equation, is addressed here with respect to the linear geometric potential $\frac{n-2}{4(n-1)} {{\mathrm{Scal}}}_g,\, {{\mathrm{Scal}}}_g$ being the Scalar curvature of $\left( M,g\right) $ . We show that a-priori $L^\infty $ –bounds fail for linear perturbations on all manifolds with $n\ge 4$ as well as a-priori gradient $L^2$ –bounds fail for non-locally conformally flat manifolds with $n\ge 6$ and for locally conformally flat manifolds with $n\ge 7$ . In several situations, the results are optimal. Our proof combines a finite dimensional reduction and the construction of a suitable ansatz for the solutions generated by a family of varying metrics in the conformal class of $g$ .     

From exaptation to radical niche construction in biological and technological complex systems

Biological adaptation assumes the evolution of structures toward better functions. Yet, the roots of adaptive trajectories usually entail subverted—perverted—structures, derived from a different function: what Gould and Vrba called “exaptation.” Generally, this derivation is regarded as contingent or serendipitous, but it also may have regularities, if not rules, in both biological evolution and technological innovation. On the basis of biological examples and examples from the history of technology, the authors demonstrate the centrality of exaptation for a modern understanding of niche, selection, and environment. In some cases, biological understanding illuminates technical exaptation. Thus, the driver of exaptation is not simply chance matching of function and form; it depends on particular, permissive contexts. © 2013 Wiley Periodicals, Inc. Complexity 18: 7–14, 2013     

Cyclopropyl-containing sulfonyl amino acids: Exploring the enantioseparation through chiral ligand-exchange chromatography

Russian Journal of General Chemistry - In the scope of a broader study focused on glutamate receptors regulators, we have been engaged in synthesis, analysis and pharmacological characterization of...     

Clustering of financial time series

This paper addresses the topic of classifying financial time series in a fuzzy framework proposing two fuzzy clustering models both based on GARCH models. In general clustering of financial time series, due to their peculiar features, needs the definition of suitable distance measures. At this aim, the first fuzzy clustering model exploits the autoregressive representation of GARCH models and employs, in the framework of a partitioning around medoids algorithm, the classical autoregressive metric. The second fuzzy clustering model, also based on partitioning around medoids algorithm, uses the Caiado distance, a Mahalanobis-like distance, based on estimated GARCH parameters and covariances that takes into account the information about the volatility structure of time series. In order to illustrate the merits of the proposed fuzzy approaches an application to the problem of classifying 29 time series of Euro exchange rates against international currencies is presented and discussed, also comparing the fuzzy models with their crisp version.     

Convergence of relaxation schemes for conservation laws

We study the stability and the convergence for a class of relaxing numerical schemes for conservation laws. Following the approach recently proposed by S. Jin and Z. Xin we use a semilinear local relaxation approximation, with a stiff lower order term, and we construct some numerical first and second order accurate algorithms, which are uniformly bounded in the L^∞ and BV norms with respect to the relaxation parameter. The relaxation limit is also investigated.     

(S)-(-)-alpha,alpha-Di(2-naphthyl)-2-pyrrolidinemethanol, a useful tool to study the recognition mechanism in chiral ligand-exchange chromatography

A dynamic coating of the RP-18 carbon chain layers with the new chiral selector (S)-(-)-alpha,alpha-di(2-naphthyl)-2-pyrrolidinemethanol allowed the formation of a mixed chiral stationary phase that has been used in the separation of a selected set of amino acid racemates. Both a representative model and classification structure-property relationship studies have been performed in order to study the contribution of hydrophobic, bulky and electron-donating groups in the side chain of the chiral selector to the mechanism of chiral recognition.     

Correlation between CMC and chromatographic index: simple and effective evaluation of the hydrophobic/hydrophilic balance of bile acids

The discovery that bile acids are involved in the modulation of nuclear steroid receptors has prompted renewed interest in this field of research. Due to the nature of research in this field, a technique that enables simple and effective assessment of the hydrophobic/hydrophilic balance, thus improving and speeding up evaluations of the biological profiles of these compounds, is greatly needed. In this context, both CMC value determination and RP-HPLC mobility evaluation were explored as possible approaches. While the CMC was calculated using the noninvasive conductimetric method, the RP-HPLC mobility was assessed by measuring the retention factor at several mobile phase compositions and extrapolating back to the pure aqueous mobile phase. The correlation of the CMC with the derived chromatographic hydrophobic index ϕ ₀ was satisfactory. Figure Experimental versus predicted pCMC values     

Compactness along the branch of semistable and unstable solutions for an elliptic problem with a singular nonlinearity

We study the branch of semistable and unstable solutions (i.e., those whose Morse index is at most 1) of the Dirichlet boundary value problem ? Δu = λf(x)/(1 ? u)² on a bounded domain Ω ? ?^N, which models—among other things—a simple electrostatic microelectromechanical system (MEMS) device. We extend the results of 11 relating to the minimal branch, by obtaining compactness along unstable branches for 1 ≤ N ≤ 7 on any domain Ω and for a large class of “permittivity profiles” f. We also show the remarkable fact that powerlike profiles f(x) ? |x|^α can push back the critical dimension N = 7 of this problem by establishing compactness for the semistable branch on the unit ball, also for N ≥ 8 and as long as As a byproduct, we are able to follow the second branch of the bifurcation diagram and prove the existence of a second solution for λ in a natural range. In all these results, the conditions on the space dimension and on the power of the profile are essentially sharp. © 2007 Wiley Periodicals, Inc.