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991.
Metabolomic profiling offers direct insights into the chemical environment and metabolic pathway activities at sites of human disease. During infection, this environment may receive important contributions from both host and pathogen. Here we apply an untargeted metabolomics approach to identify compounds associated with an E. coli urinary tract infection population. Correlative and structural data from minimally processed samples were obtained using an optimized LC-MS platform capable of resolving ~2300 molecular features. Principal component analysis readily distinguished patient groups and multiple supervised chemometric analyses resolved robust metabolomic shifts between groups. These analyses revealed nine compounds whose provisional structures suggest candidate infection-associated endocrine, catabolic, and lipid pathways. Several of these metabolite signatures may derive from microbial processing of host metabolites. Overall, this study highlights the ability of metabolomic approaches to directly identify compounds encountered by, and produced from, bacterial pathogens within human hosts. 相似文献
992.
We report here a new strategy to graft both redox and DNA probes on carbon nanotubes to make a label-free DNA sensor. Oxidized single-walled carbon nanotubes are first immobilized on a self-assembled monolayer of cysteamine; then the redox probe, a quinone derivative 3-[(2-aminoethyl)sulfanyl-5-hydroxy-1,4-naphthoquinone], is grafted on the free carboxylic groups of the nanotubes. After that, for DNA probe grafting, new carboxylic sites are generated via an aryl diazonium route. After hybridization with a complementary sequence, the conformational changes of DNA could influence the redox kinetics of quinone, leading to a current increase of the redox signal, detected by square wave voltammetry. The system is selective, as it can discriminate a single mismatched sequence from the complementary one. 相似文献
993.
Hung A Mwenifumbo S Mager M Kuna JJ Stellacci F Yarovsky I Stevens MM 《Journal of the American Chemical Society》2011,133(5):1438-1450
Monolayer-protected metal nanoparticles (MPMNs) are a newly discovered class of nanoparticles with an ordered, striped domain structure that can be readily manipulated by altering the ratio of the hydrophobic to hydrophilic ligands. This property makes them uniquely suited to systematic studies of the role of nanostructuring on biomolecule adsorption, a phenomenon of paramount importance in biomaterials design. In this work, we examine the interaction of the simple, globular protein cytochrome C (Cyt C) with MPMN surfaces using experimental protein assays and computational molecular dynamics simulations. Experimental assays revealed that adsorption of Cyt C generally increased with increasing surface polar ligand content, indicative of the dominance of hydrophilic interactions in Cyt C-MPMN binding. Protein-surface adsorption enthalpies calculated from computational simulations employing rigid-backbone coarse-grained Cyt C and MPMN models indicate a monotonic increase in adsorption enthalpy with respect to MPMN surface polarity. These results are in qualitative agreement with experimental results and suggest that Cyt C does not undergo significant structural disruption upon adsorption to MPMN surfaces. Coarse-grained and atomistic simulations furthermore elucidated the important role of lysine in facilitating Cyt C adsorption to MPMN surfaces. The amphipathic character of the lysine side chain enables it to form close contacts with both polar and nonpolar surface ligands simultaneously, rendering it especially important for interactions with surfaces composed of adjacent nanoscale chemical domains. The importance of these structural characteristics of lysine suggests that proteins may be engineered to specifically interact with nanomaterials by targeted incorporation of unnatural amino acids possessing dual affinity to differing chemical motifs. 相似文献
994.
Mathieu A. Derbanne Vincent Besse Stéphane Le Goff Michaël Sadoun Thi-Nhàn Pham 《Polymer Degradation and Stability》2013
This study deals with the stability of new phosphonic monomers bearing an acrylamide moiety designed to increase the adhesion durability. Synthesis of monomers bearing acrylamide and methacrylate moieties, as well as their use in Self-Etch Adhesives is reported. The adhesion of a degraded methacrylate based adhesive has been evaluated. Homologous self-etching primers containing monomers bearing acrylamide or methacrylate were formulated and used either immediately after formulation or after 18 months. Their adhesive performances were assessed by shear bond strength testing and their degradation measured by NMR, HPLC-MS. While no differences were found in terms of adhesion between fresh and aged acrylamide based adhesive, the instability of methacrylate based ones was demonstrated. Nevertheless, methacrylate based SEAs still have good adhesion abilities. The co-monomer used, N,N′-diethyl-1,3-bis(acrylamido)propane is expected to be responsible for good mechanical properties even for degraded SEAs. Lastly, the stability of acrylamide monomer seems to be of interest in the prospect of developing SEA with longer shelf life. 相似文献
995.
996.
A one-pot procedure was developed for the synthesis of isoindolin-1-imine derivatives by a simple three-component condensation of 2-cyanobenzaldhyde, ammonium acetate, and 4-hyroxycoumarin derivatives or 1,3-dicarbonyl compounds or 4-hydroxyquinolin-2(1H)-one in ethanol under reflux for 20–60 min with excellent yields. The advantages of this procedure are operational simplicity, excellent yields, and short reactive time, without catalyst, easy workup, and green environmental impact. 相似文献
997.
In 1972 we proposed1 structure 3 for flavipucine, an antibiotic from an Aspergillus flavipes strain. Later we reported2 a novel reaction of 6-methyl-4-hydroxy-2-pyridone with α keto aldehydes which provided 1a from isobutylglyoxal and it was stated that we believed 1a would serve as a key intermediate in the total synthesis of flavipucine 3. 相似文献
998.
J. Hung D. Ortega J. Castillo S. Acevedo 《Journal of Dispersion Science and Technology》2013,34(5):717-723
The kinetic of coalescence of water in Furrial crude oil emulsions (W/O) during the initial stage of demulsification process is showed through of high‐resolution image micrographics by using a confocal microscope. Furrial crude oil from Monagas state is a crude oil extra heavy with severe flocculation/aggregation problems. The kinetic of the initial stage in the coalescence process is critical and of great importance in the definition of the foreword behavior. This information allowed us to characterize the demulsification rate process in a Furrial crude oil. Total W/O emulsion separation was achieved about of 2 hours at 80ºC. The initial fast coalescence is characterized by a short binary coalescence time, which is followed by a large binary coalescence time. Our results demonstrate that the initial coalescence rate determinate the time necessary to achieve a total separation. 相似文献
999.
In order to investigate the photochemical tuning capability of chiral monomers and polymers containing end‐capped menthyl groups, a new series of chiral dopants was synthesized and added to commercially available nematic liquid crystals to induce cholesteric liquid crystal (LC) phases. The addition of chiral dopants with azo structure led to phototunability of the reflection colour of the LC cells. Photochromic variation of the LC cells due to photoisomerization of the azo compound was investigated. After photopolymerization of the monomers inside the cholesteric LC cells, the centre wavelength of the reflected band of the incident light was found to be fixed and the reflected bandwidth was broadened, resulting in a red shift. A schematic representation of both the photoisomerization of the azo dopants and its effect on variation of twisting pitches is proposed. Real image recording was performed using 365 nm UV through a mask with text. The top and side views of the morphological network structures of a fabricated cholesteric LC cell were investigated using scanning electron microscopy. The results of this investigation demonstrated that RGB reflected colours of LC cells can easily be achieved through the addition of the menthyl‐containing synthesized chiral compounds to nematic LCs. The addition of synthesized AzoM helped further in recording the patterns onto cholesteric LC films using 365 nm UV exposure. 相似文献
1000.
Dr. Fadlilatul Taufany Dr. Chun‐Jern Pan Feng‐Ju Lai Dr. Hung‐Lung Chou Loka Subramanyam Sarma Dr. John Rick Jhih‐Min Lin Dr. Jyh‐Fu Lee Dr. Mau‐Tsu Tang Prof. Bing‐Joe Hwang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(3):905-915
A controlled composition‐based method—that is, the microwave‐assisted ethylene glycol (MEG) method—was successfully developed to prepare bimetallic PtxRu100?x/C nanoparticles (NPs) with different alloy compositions. This study highlights the impact of the variation in alloy composition of PtxRu100?x/C NPs on their alloying extent (structure) and subsequently their catalytic activity towards the methanol oxidation reaction (MOR). The alloying extent of these PtxRu100?x/C NPs has a strong influence on their Pt d‐band vacancy and Pt electroactive surface area (Pt ECSA); this relationship was systematically evaluated by using X‐ray absorption (XAS), scanning electron microscopy (SEM) coupled with energy dispersive X‐ray spectroscopy (EDX), transmission electron microscopy (TEM), density functional theory (DFT) calculations, and electrochemical analyses. The MOR activity depends on two effects that act in cooperation, namely, the number of active Pt sites and their activity. Here the number of active Pt sites is associated with the Pt ECSA value, whereas the Pt‐site activity is associated with the alloying extent and Pt d‐band vacancy (electronic) effects. Among the PtxRu100?x/C NPs with various Pt:Ru atomic ratios (x=25, 50, and 75), the Pt75Ru25/C NPs were shown to be superior in MOR activity on account of their favorable alloying extent, Pt d‐band vacancy, and Pt ECSA. This short study brings new insight into probing the synergistic effect on the surface reactivity of the PtxRu100?x/C NPs, and possibly other bimetallic Pt‐based alloy NPs. 相似文献