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排序方式: 共有468条查询结果,搜索用时 15 毫秒
371.
Chelebaeva E Larionova J Guari Y Ferreira RA Carlos LD Paz FA Trifonov A Guérin C 《Inorganic chemistry》2008,47(3):775-777
A new cyano-bridged coordination polymer network Tb(H2O)5-[Mo(CN)8] was obtained and characterized. This compound has a two-dimensional layered structure and presents luminescence along with a magnetic transition at low temperature. 相似文献
372.
Mehiaoui Nawel Kibou Zahira Gallavardin Thibault Leleu Stéphane Franck Xavier Mendes Ricardo F. Paz Filipe A. Almeida Silva Artur M. S. Choukchou-Braham Noureddine 《Research on Chemical Intermediates》2021,47(4):1331-1348
Research on Chemical Intermediates - Novel substituted bis-(3-cyano-2-pyridone) derivatives were prepared via a powerful method using enaminonitriles push–pull dienes as key building blocks.... 相似文献
373.
Raja R Thomas JM Greenhill-Hooper M Ley SV Almeida Paz FA 《Chemistry (Weinheim an der Bergstrasse, Germany)》2008,14(8):2340-2348
Niacin (3-picolinic acid), which is extensively used as vitamin B3 in foodstuffs and as a cholesterol-lowering agent, along with other oxygenated products of the picolines, 4-methylquinoline, and a variety of pyrimidines and pyridazines, may be produced in a single-step, environmentally benign fashion by combining single-site, open-structure, heterogeneous catalysts with a solid source of active oxygen, namely acetyl peroxyborate (APB), in the absence of an organic solvent. The high activities, selectivities, and the relatively mild conditions employed with this single-site heterogeneous catalyst, coupled with ease of transport, storage, and stability of the solid oxidant, augurs well for the future use of APB in conjunction with other open-structure, single-site catalysts for fine-chemical, pharmaceutical, and agrochemical applications. 相似文献
374.
Kowalchuk CM Paz FA Ananias D Pattison P Carlos LD Rocha J 《Chemistry (Weinheim an der Bergstrasse, Germany)》2008,14(27):8157-8168
The hydrothermal synthesis and structural characterization of the lanthanide silicate system [Na(6)Ln(2)Si(12)O(30).x H(2)O] (Ln=La(3+), Sm(3+), Eu(3+), Gd(3+), and Tb(3+)), named AV-21, has been reported. Structural elucidation of the Sm(3+) analogue (isomorphous with the Eu(3+), Gd(3+), and Tb(3+) frameworks) using single-crystal synchrotron X-ray diffraction and solid-state NMR spectroscopy reveal disorder in the Si(1) second coordination sphere. La-AV-21 presents a distinct framework. These materials combine microporosity and interesting photoluminescence features with structural flexibility that allows the introduction of a second or third type of lanthanide center. Room-temperature lifetime decay dynamics have been used to estimate the Ln(3+)-Ln(3+) distances and the maximum distance over which energy transfer is active. Though the majority of Ln(3+) centers occupy regular framework positions, the Ln(2) defect centers are disordered over the Na(1) sites in the pores and greatly influence the energy-transfer process, providing a unique opportunity for studying the relationship between structural disorder and photoluminescence properties in framework solids. 相似文献
375.
Mitomycin C, (MC), an antitumor drug used in the clinics, is a DNA alkylating agent. Inert in its native form, MC is reduced to reactive mitosenes in cellulo which undergo nucleophilic attack by DNA bases to form monoadducts as well as interstrand crosslinks (ICLs). These properties constitute the molecular basis for the cytotoxic effects of the drug. The mechanism of DNA alkylation by mitomycins has been studied for the past 30 years and, until recently, the consensus was that drugs of the mitomycins family mainly target CpG sequences in DNA. However, that paradigm was recently challenged. Here, we relate the latest research on both MC and dicarbamoylmitomycin C (DMC), a synthetic derivative of MC which has been used to investigate the regioselectivity of mitomycins DNA alkylation as well as the relationship between mitomycins reductive activation pathways and DNA adducts stereochemical configuration. We also review the different synthetic routes to access mitomycins nucleoside adducts and oligonucleotides containing MC/DMC DNA adducts located at a single position. Finally, we briefly describe the DNA structural modifications induced by MC and DMC adducts and how site specifically modified oligonucleotides have been used to elucidate the role each adduct plays in the drugs cytotoxicity. 相似文献
376.
The influence of cationic and anionic surfactants and short‐chain alcohols in the mobile phase on the retention of five antioxidants has been studied. The solutes chosen were butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and propyl, octyl, and dodecyl gallates (PG, OG, DG).The surfactants were hexadecyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS), and n‐propanol (PrOH) was the selected alcohol. A simple isocratic reversed‐phase method for the antioxidant determination is proposed. Separation of five primary antioxidants takes 18 min with the mobile phase SDS 0.10 M/H3PO4 0.01 M/PrOH 30%. Variation of the percentage of alcohol in the mobile phase permits optimization of the retention times of the antioxidants. Detection limits in the pg range were obtained for the all solutes. The method was used to determine the antioxidants in olive oil at three different levels, giving mean recoveries close to 100% for all the solutes (BHA 102%, PG 99%, OG 99%, DG 99%) except BHT (84%). 相似文献
377.
Elena Alba lvaro-Alonso Ma Paz Lorenzo Andrea Gonzalez-Prieto Elsa Izquierdo-García Ismael Escobar-Rodríguez Antonio Aguilar-Ros 《Molecules (Basel, Switzerland)》2022,27(9)
In this article, we studied physicochemical and microbiological stability and determined the beyond-use date of two oral solutions of methadone in three storage conditions. For this, two oral solutions of methadone (10 mg/mL) were prepared, with and without parabens, as preservatives. They were packed in amber glass vials kept unopened until the day of the test, and in a multi-dose umber glass bottle opened daily. They were stored at 5 ± 3 °C, 25 ± 2 °C and 40 ± 2 °C. pH, clarity, and organoleptic characteristics were obtained. A stability-indicating high-performance liquid chromatography method was used to determine methadone. Microbiological quality was studied and antimicrobial effectiveness testing was also determined following European Pharmacopoeia guidelines. Samples were analyzed at days 0, 7, 14, 21, 28, 42, 56, 70, and 91 in triplicate. After 91 days of storage, pH remained stable at about 6.5–7 in the two solutions, ensuring no risk of methadone precipitation. The organoleptic characteristics remained stable (colorless, odorless, and bitter taste). The absence of particles was confirmed. No differences were found with the use of preservatives. Methadone concentration remained within 95–105% in all samples. No microbial growth was observed. Hence, the two oral methadone solutions were physically and microbiologically stable at 5 ± 3 °C, 25 ± 2 °C, and 40 ± 2 °C for 91 days in closed and opened amber glass bottles. 相似文献
378.
Nunes Ernane Nogueira Rocha Ana Paula Trindade de Araújo Gilmar Trindade de Paz Adeilton Padre Rodrigues Larissa Monique de Sousa Batista Rayanne Sales de Araújo Melo Taynara Batista Lins 《Journal of Thermal Analysis and Calorimetry》2019,135(6):3281-3288
Journal of Thermal Analysis and Calorimetry - Large amounts of plant biomass generated daily and not harnessed for lack of adequate technologies. Based on this context, this study aimed to perform... 相似文献
379.
Susana Santos Braga Firas El-Saleh Karyna Lysenko Filipe A. Almeida Paz 《Molecules (Basel, Switzerland)》2021,26(3)
Efavirenz is an antiretroviral drug of widespread use in the management of infections with human immunodeficiency virus type 1 (HIV-1). Efavirenz is also used in paediatrics, but due to its very poor aqueous solubility the liquid formulations available resort to oil-based excipients. In this report we describe the interaction of γ-cyclodextrin with efavirenz in solution and in the solid state. In aqueous solution, the preferential host–guest stoichiometry was determined by the continuous variation method using 1H NMR, which indicated a 3:2 host-to-guest proportion. Following, the solid inclusion compound was prepared at different stoichiometries by co-dissolution and freeze-drying. Solid-state characterisation of the products using FT-IR, 13C{1H} CP-MAS NMR, thermogravimetry, and X-ray powder diffraction has confirmed that the 3:2 stoichiometry is the adequate starting condition to isolate a solid inclusion compound in the pure form. The effect of γ-cyclodextrin on the solubility of efavirenz is studied by the isotherm method. 相似文献
380.
A. I. Komech A. E. Merzon A. Esquivel Navarrete J. E. De La Paz Mndez T. J. Villalba Vega 《Mathematical Methods in the Applied Sciences》2019,42(15):4957-4970
We analyze the Sommerfeld solution to the stationary diffraction by a half‐plane. We prove that this solution is the limiting amplitude for time‐dependent scattering of incident plane waves with a broad class of the profile functions. We also show that this solution is the asymptotics of the limiting amplitudes of solutions to time‐dependent scattering problem with narrow wedges when the angle of the wedge tends to zero. 相似文献