Introduction of a Carboxymethylamino(or oxy Or thio) Group in the 3 Position of 2-Aryl(or Arylmethyl)isoindol-1-ones from α Hydroxylactams

The preparation of 3-carboxymethylamino (or oxy or thio)-2-aryl (or arylmethyl)-isoindol-1-ones are described from hydroxylactams according to three different pathways.     

Synthesis and Separation of New Dibenz[b,d]azonine Atropisomers

A synthesis of the dibenz[b,d]azonine atropisomers (14) from 2-phenylbenzoic acid is described. This heterocycle belongs to a new series of biaryl compounds with potential antitubulin activity.     

SYNTHESIS OF α-AND β-OLEFINIC DITHIOESTERS - REACTIONS WITH GRIGNARD REAGENTS - SYNTHESIS OF ARTEMISIA KETONE

Abstract

A new synthesis of dithioesters, starting from phenylisothiocyanate is described (scheme I) and this method is convenient for the preparation of β-olefinic dithioesters (e. g. 1, scheme II).     

Synthesis of 8-vinyladenosine 5′-di- and 5′-triphosphate: evaluation of the diphosphate compound on ribonucleotide reductase

The synthesis of 5′-di- and 5′-triphosphate of 8-vinyladenosine to be tested on ribonucleotide reductases requires the modification of known methods. The phosphate group was introduced by treatment with an in situ generated chlorophosphite. Protection of the 2′,3′ diol with acetyl groups suppressed depurination during acid removal of the phosphotriester protecting groups. The di- and triphosphate compounds were obtained by treatment of the activated adenylic acid with phosphate or pyrophosphate anions followed by removal of the acetate protecting groups. Preliminary studies were conducted on Escherichia coli ribonucleotide reductase and have shown that the diphosphate compound is efficiently reduced.     

A DFT study of lithium battery materials: application to the β-VOXO4 systems (X=P, As, S)

VOXO₄ systems have been considered as potential lithium battery electrodes. They mainly present two distinct structural types: the tetragonal “α” type with a two-dimensional framework, and the three-dimensional orthorhombic “β”. DFT calculations were performed on this latter system for several β-Li_xVOXO₄ compounds (x=0, 1; X=P, As, S). They allowed to propose structural models for VOAsO₄ and LiVOSO₄, not fully crystallographically well described yet. Based on an experimental model of two-phase processes, these calculations led also to a good simulation of electrochemical potential values. A density of states analysis put in evidence the “inductive effect” and the role played by (XO₄)ⁿ⁻ groups inside the host frameworks on these potentials.     

Direct HPLC resolution of beta-aminoalcohol (tazifylline,ranolazine, sotalol) enantiomers

Summary A routine chiral analysis has been developed to control the optical purity of chiral drugs and to monitor their asymmetric synthesis. The recent advent of new chiral stationary phases for HPLC enabled us to achieve the direct resolution of chiral drugs without any derivatization. The factors affecting chiral resolution on a new alpha₁-acid glycoprotein column (EnantioPac, LKB) were assessed with three beta-aminoalcohols.     

Optimization of Sr-90 precipitation in nitric acid using design of experiments for radioactive waste characterization method

Journal of Radioanalytical and Nuclear Chemistry - 90Sr radiochemical method using nitric acid for Sr and Ca separation was optimized using design of experiments methodology. Nitric acid...