全文获取类型
收费全文 | 79篇 |
免费 | 3篇 |
专业分类
化学 | 47篇 |
晶体学 | 3篇 |
力学 | 1篇 |
数学 | 11篇 |
物理学 | 20篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 5篇 |
2020年 | 2篇 |
2019年 | 2篇 |
2018年 | 2篇 |
2017年 | 1篇 |
2016年 | 3篇 |
2015年 | 1篇 |
2013年 | 10篇 |
2012年 | 4篇 |
2011年 | 3篇 |
2010年 | 6篇 |
2009年 | 4篇 |
2008年 | 5篇 |
2007年 | 3篇 |
2006年 | 3篇 |
2005年 | 1篇 |
2004年 | 1篇 |
2002年 | 2篇 |
2001年 | 1篇 |
1999年 | 1篇 |
1996年 | 1篇 |
1993年 | 1篇 |
1988年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1967年 | 1篇 |
1961年 | 1篇 |
排序方式: 共有82条查询结果,搜索用时 32 毫秒
61.
Hepcidin is a small cysteine-rich peptide that plays an important role in antimicrobial activity and in maintaining iron homeostasis
in vertebrates. Here we report on the underlying mechanism that maintains high sequence diversities among the hepcidin-like
variants of perciform and pleuronectiform fishes. In contrast to mammals, maximum likelihood-based codon substitution analyses
revealed that positive Darwinian selection (nonsynonymous to synonymous substitution, ω > 1) is the likely cause of accelerated rate of amino acid substitutions in the hepcidin mature peptide region of these
fishes. Comparison of models incorporating positive selection (ω > 1) at certain sites with models not incorporating positive selection (ω < 1) failed to reject (p = 0) the evidence of positive selection among the codon sites of percifom and pleuronectiform hepcidin. The adaptive evolution
of this peptide in perciform and pleuronectiform fishes might be directed by pathogens when the host is exposed to new habitats/environments. 相似文献
62.
The bivalent zinc and cadmium complexes of two Schiff bases N-(2-pyridylmethyl)pyridine-2-carbaldimine (L1), N-(2-pyridylmethyl)pyridine-2-methylketimine (L2), tridentate ligands with an N3 chromophore and coordinating with two five-membered chelate rings, were synthesized. Complexes [Zn(L1)(NO3)2] (1), [Zn(L2)(NO3)2] (2), [Cd(L1)(NO3)2(H2O)] (3) and [Cd(L2)(NO3)2(CH3OH)] (4) were characterized by X-ray crystallography. In 1 and 2, Zn(II) has a distorted square-pyramidal geometry where as in 3 and 4, Cd(II) possesses a pseudo-pentagonal-bipyramidal geometry. The following trends in the bond lengths are observed: M–Nim < M–Npy; Zn–N > Zn–O; Cd–N < Cd–O. The final residues from the thermogravimetric analysis are ZnO and CdO, the SEM studies revealed, respectively, their porous and spherical natures. The average activation energy (E) for the loss of pyridine rings obtained from the Friedman fitting of the DSC data, for 1, 2, 3, and 4 are 193.8(2), 114.5(3), 127.1(4), and 63.7(3) kJ mol−1 and their logarithmic pre-exponential factor (A) are 11.22, 5.31, 6.88, and 2.09, respectively. 相似文献
63.
Prediction of the structures of helical membrane proteins based on a minimum unfavorable contacts approach
下载免费PDF全文
![点击此处可从《Journal of computational chemistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Siladitya Padhi Siddabattula Ramakrishna U. Deva Priyakumar 《Journal of computational chemistry》2015,36(8):539-552
An understanding of structure–function relationships of membrane proteins continues to be a challenging problem, owing to the difficulty in obtaining their structures experimentally. This study suggests a method for modeling membrane protein structures that can be used to generate a reliable initial conformation prior to the use of other approaches for sampling conformations. It involves optimizing the orientation of hydrophilic residues so as to minimize unfavorable contacts with the hydrophobic tails of the lipid bilayer. Starting with the optimized initial conformation for three different proteins modeled based on this method, two independent approaches have been used for sampling the conformational space of the proteins. Both approaches are able to predict structures reasonably close to experimental structures, indicating that the initial structure enables the sampling of conformations that are close to the native structure. Possible improvements in the method for making it broadly applicable to helical membrane proteins are discussed. © 2015 Wiley Periodicals, Inc. 相似文献
64.
Gupta Padmini Garkoti Charu Shabir Javaid Surabhi Sah Digvijay Mozumdar Subho 《Research on Chemical Intermediates》2021,47(10):4013-4028
Research on Chemical Intermediates - This work describes the synthesis of magnetic graphene oxide (MGO), where iron oxide (Fe3O4) nanoparticles were uniformly deposited over the sheets of the... 相似文献
65.
A Chatterjee Sushil Kamerkar A K Jethra S Padmini M P Diwakar S S Pande M D Ghodgaonkar 《Pramana》2001,57(1):135-139
Experiments with multi-detector arrays have special requirements and place higher demands on computer data acquisition systems.
In this contribution we discuss data acquisition systems with special emphasis on multi-detector arrays and in particular
we describe a new data acquisition system, AMPS which we have developed recently which is in regular use in experiments at
the Pelletron Laboratory, Mumbai. This includes the in-house development of a dedicated crate controller, PC interface card
and software. 相似文献
66.
The various isomers including stable structures, carbenes, and diradicals on the C3H4 surface have been investigated. The two carbenes propenylidene and cyclopropylidene have been found to have singlet ground states. Vinylmethylene is predicted to have a triplet ground state with a planar diradical type of structure. The syn and anti forms of this state are degenerate. This is in agreement with the observation of two triplet states in the electron spin resonance (ESR ) spectra. The π electrons are found to be delocalized over the three carbons. The singlet diradical structures are found to be more stable than the carbene structures, which retain the CH2 (DOUBLE BOND) CH allylic structures. The orbital compositions of the frontier orbitals of all systems have been determined to examine the nature of these orbitals. © 1996 John Wiley & Sons, Inc. 相似文献
67.
Petre Badica Nicolae Dan Batalu Mariana Carmen Chifiriuc Mihail Burdusel Mihai Alexandru Grigoroscuta Gheorghe Virgil Aldica Iuliana Pasuk Andrei Kuncser Marcela Popa Angelo Agostino Lorenza Operti Santanu Kumar Padhi Valentina Bonino Marco Truccato 《Molecules (Basel, Switzerland)》2021,26(19)
Pristine high-density bulk disks of MgB2 with added hexagonal BN (10 wt.%) were prepared using spark plasma sintering. The BN-added samples are machinable by chipping them into desired geometries. Complex shapes of different sizes can also be obtained by the 3D printing of polylactic acid filaments embedded with MgB2 powder particles (10 wt.%). Our present work aims to assess antimicrobial activity quantified as viable cells (CFU/mL) vs. time of sintered and 3D-printed materials. In vitro antimicrobial tests were performed against the bacterial strains Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 25923, Enterococcus faecium DSM 13590, and Enterococcus faecalis ATCC 29212; and the yeast strain Candida parapsilosis ATCC 22019. The antimicrobial effects were found to depend on the tested samples and microbes, with E. faecium being the most resistant and E. coli the most susceptible. 相似文献
68.
Padmini Ramaswamy Sukhendu Mandal Srinivasan Natarajan 《Journal of solid state chemistry》2009,182(9):2491-2496
A novel manganese phosphite-oxalate, [C2N2H10][Mn2II(OH2)2(HPO3)2(C2O4)] has been hydothermally synthesized and its structure determined by single-crystal X-ray diffraction. The structure consists of neutral manganese phosphite layers, [Mn(HPO3)]∞, formed by MnO6 octahedra and HPO3 units, cross-linked by the oxalate moieties. The organic cations occupy the middle of the 8-membered one-dimensional channels. Magnetic studies indicate weak antiferromagnetic interactions between the Mn2+ ions. 相似文献
69.
Dharmendra Das Zigmee T. Bhutia Padmini C. Panjikar Amrita Chatterjee Mainak Banerjee 《Journal of heterocyclic chemistry》2020,57(11):4099-4107
A green and efficient mechanochemical method for the synthesis of a series of 2-arylimidazo[1,2-a]pyridines was developed using an electrical grinder. I2 catalyzed mechanochemical grinding facilitates the cyclocondensation reaction between various aryl methyl ketones and 2-aminopyridines to afford 2-arylimidazo[1,2-a]pyridines in good yields at ambient temperature. The method was successfully used for the gram-scale synthesis of a marketed drug, zolimidine. The noticeable advantages of this environmentally sustainable protocol include mild conditions, simple instrumentation, inexpensive catalyst, atom economy, short reaction time etc. 相似文献
70.
Rajendran Sribalan Andiappan Lavanya Maruthan Kirubavathi Vediappen Padmini 《Journal of Saudi Chemical Society》2018,22(2):198-207
An efficient synthetic procedure has been achieved for selective synthesis of 1,5-disubstituted tetrazoles and diaryl ureas from secondary amides in situ in the presence of NaN3 and POCl3 as solvent, both by conventional and microwave methods. The reaction conditions were optimized to yield selectively either tetrazoles or urea derivatives from reasonable to excellent yields. These conversions have been tested and verified with various secondary amide precursors. The synthesized compounds were characterized by 1H NMR, 13C NMR and ESI-MS spectroscopic techniques. 相似文献