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991.
Zahia Houiene Mounia Merabet-Khelassi Nassima Bouzemi Olivier Riant Louisa Aribi-Zouioueche 《Tetrahedron: Asymmetry》2013,24(5-6):290-296
Herein we report results of the chemoenzymatic deracemization of a range of secondary benzylic acetates 1a–9a via a sequence of hydrolysis with CAL-B lipase in non-conventional media, combined with esterification of the recovered alcohol according to the Mitsunobu protocol following an enzymatic kinetic resolution (KR). The KR of racemic acetates 1a–9a via an enzymatic hydrolysis, with CAL-B lipase and Na2CO3, in non-aqueous media was optimized and gave high selectivities (E ? 200) at good conversions (C >49%) for all of the substrates studied. This method competes well with the traditional one performed in a phosphate buffer solution. The deracemization using Mitsunobu inversion gave the (S)-acetates in moderate to excellent enantiomeric excess 75% < ee < 99%, in acceptable isolated yields 70% < yield < 89%, and with some variations according to the acetate structure. 相似文献
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995.
One‐Step Double Covalent Functionalization of Reduced Graphene Oxide with Xanthates and Peroxides 下载免费PDF全文
Florence Pennetreau Prof. Olivier Riant Prof. Sophie Hermans 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(46):15009-15012
Radical functionalization of reduced graphene oxide has been achieved by reaction with a xanthate in the presence of peroxide as a radical initiator. X‐ray photoelectron spectroscopy, bulk elemental analyses, and thermogravimetric analyses showed that the xanthate grafting is covalent and efficient. The synthesis and use of seven xanthates and three peroxides showed that the highest grafting yield is obtained when xanthate and peroxide are introduced in stoichiometric amounts. It also revealed that the peroxide used as radical initiator is grafted at the graphenic surface during the functionalization. The method presented in this contribution therefore allows bifunctionalized reduced graphene oxide samples to be easily obtained in one single step. This method leads to undamaged graphene sheets with higher dispersibility than the pristine sample. 相似文献
996.
Stable Isotope Labeling by Amino acid in Vivo (SILAV): a new method to explore protein metabolism 下载免费PDF全文
997.
We investigated the tandem conjugated borylation–aldol reaction catalyzed by copper complexes. After identification and optimisation of the catalytic system, the scope of the reaction was evaluated and the diastereoselectivity was studied on both linear and cyclic activated alkenes. Finally, the use of some selected borylated aldol adducts in two classical transformations was investigated. 相似文献
998.
René‐Ponce Nzé Olivier Colombani Erwan Nicol 《Journal of polymer science. Part A, Polymer chemistry》2012,50(19):4046-4054
Poly(vinyl laurate) (PVL) and poly(vinyl stearate) (PVS) were synthesized by means of cobalt‐mediated radical polymerization (CMRP). Cobalt(II) diacetylacetonate (Co(acac)2) was demonstrated to control the radical polymerization of these monomers in solution. Molecular weights up to 15,000 g·mol?1 were obtained with reasonably low polydispersity indices (PDI < 1.3). The efficiency of the redox initiator [lauroyle peroxide (LPO)/citric acid (CA)] was found to be low (around 10%) as already reported for vinyl acetate. The solvent and temperature were found to have a very weak influence on the initiator efficiency. It appeared that CA played no role in the initiation process that only involved a redox reaction between LPO and Co(acac)2. PVL‐b‐PVS diblock copolymers could be synthesized using two strategies: (1) Sequential addition, that is, addition of the second monomer (VS) at high conversion of the first one (VL). (2) Macroinitiator technique, that is, isolation of a PVL macroinitiator then polymerization of VS from this cobalt functionalized macroinitiator. Both techniques allowed the synthesis of diblock copolymers with molar masses around 25,000 g·mol?1 and PDI lower than 1.4. The resulting materials were characterized by DSC, revealing that both blocks exhibit side‐chain crystallinity and phase segregate in the bulk. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012 相似文献
999.
Organometallic Derivatization of the Nematocidal Drug Monepantel Leads to Promising Antiparasitic Drug Candidates 下载免费PDF全文
Jeannine Hess Dr. Malay Patra Dr. Loganathan Rangasamy Sandro Konatschnig Dr. Olivier Blacque Dr. Abdul Jabbar Patrick Mac Dr. Erik M. Jorgensen Prof. Dr. Robin B. Gasser Prof. Dr. Gilles Gasser 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(46):16602-16612
The discovery of novel drugs against animal parasites is in high demand due to drug‐resistance problems encountered around the world. Herein, the synthesis and characterization of 27 organic and organometallic derivatives of the recently launched nematocidal drug monepantel (Zolvix®) are described. The compounds were isolated as racemates and were characterized by 1H, 13C, and 19F NMR spectroscopy, mass spectrometry, and IR spectroscopy, and their purity was verified by microanalysis. The molecular structures of nine compounds were confirmed by X‐ray crystallography. The anthelmintic activity of the newly designed analogues was evaluated in vitro against the economically important parasites Haemonchus contortus and Trichostrongylus colubriformis. Moderate nematocidal activity was observed for nine of the 27 compounds. Three compounds were confirmed as potentiators of a known monepantel target, the ACR‐23 ion channel. Production of reactive oxygen species may confer secondary activity to the organometallic analogues. Two compounds, namely, an organic precursor ( 3 a ) and a cymantrene analogue ( 9 a ), showed activities against microfilariae of Dirofilaria immitis in the low microgram per milliliter range. 相似文献
1000.
In this paper, we study two problems appearing in two-dimensional fluid mechanics in a constant gravity field . These two problems—the Rayleigh convection problem and the ablation front problem—generalize the Rayleigh–Taylor model in
compressible flows. The analysis of their stability relies on semiclassical techniques for the linearized system around a
reference solution. We consider normal modes which are approximate solutions corresponding to large wave numbers associated
with , and we discuss the existence or the non-existence of such normal modes. The results depend on the value of the dimensionless
growth rate Γ compared with two relevant mathematical parameters, namely σ
p
(p standing for the model) and some effective semiclassical parameter h. 相似文献