Reactions of (1E)‐Buta‐1,3‐dien‐1‐yl Acetate with Diazocarbonyl Compounds

Carbene transfer to appropriate substrates is a highly versatile tool for the construction of carbon frameworks with increased functional and structural complexity. In this study, some novel cyclopropane derivatives were synthesized via carbenoid reactions and their further reactivities were investigated. (1E)‐Buta‐1,3‐dien‐1‐yl acetate was reacted with four different diazocarbonyl compounds, ethyl diazoacetate, dimethyl diazomalonate, 1‐diazo‐1‐phenylpropan‐2‐one, and methyl (3E)‐2‐diazo‐4‐phenylbut‐3‐enoate, in the presence of two catalysts. All synthesized substituted cyclopropanes were obtained chemoselectively with respect to less‐hindered C?C bonds. Under the applied conditions, while cyclopropanes 7a and 7d underwent further reactions, cyclopropanes 7b and 7c were stable enough. Cyclopropanes 7a and an additional equivalent of ethyl diazoacetate yielded polyfunctionalized cyclohexenes. Cyclopropanes from methyl (3E)‐2‐diazo‐4‐phenylbut‐3‐enoate yielded polyfunctionalyzed cycloheptadiene isomers by Cope rearrangement.     

Simulated and experimental studies of a multi-band symmetric metamaterial absorber with polarization independence for radar applications

We develop a simple new design for a multi-band metamaterial absorber (MTMA) for radar applications. Computer Simulation Technology (CST) Studio Suite 2018 was used for the numerical analysis and absorption study. The simulated results show four high peaks at 5.6 GHz, 7.6 GHz, 10.98 GHz, and 11.29 GHz corresponding to absorption characteristics of 100%, 100%, 99%, and 99%, respectively. Furthermore, two different structures were designed and compared with the proposed MTMA. The proposed structure remained insensitive for any incident angle and polarization angle from 0° to 60°. Moreover, negative constitutive parameters were retrieved numerically. To support the simulated results, the proposed design was fabricated by using a computer numerical control-based printed circuit board prototyping machine and tested experimentally in a microwave laboratory. The absorption mechanism of the proposed MTMA is presented through the surface current and electric field distributions. The novelties of the proposed structure are a simple and new design, ease of fabrication, low cost, durability, suitability for real-time applications and long-term stability given the fabrication technique and non-destructive measurement method and very high absorption. The proposed structure has potential applications in C and X band frequency ranges.     

Momentum evolution of ejected and entrained fluid during laminar vortex ring formation

The evolution of total circulation and entrainment of ambient fluid during laminar vortex ring formation has been addressed in a number of previous investigations. Motivated by applications involving propulsion and fluid transport, the present interest is in the momentum evolution of entrained and ejected fluid and momentum exchange among the ejected, entrained fluid and added mass during vortex ring formation. To this end, vortex rings are generated numerically by transient jet ejection for fluid slug length-to-diameter (L/D) ratios of 0.5–3.0 using three different velocity programs [trapezoidal, triangular negative slope (NS), and positive slope (PS)] at a jet Reynolds number of 1,000. Lagrangian coherent structures (LCS) were utilized to identify ejected and entrained fluid boundaries, and a Runge-Kutta fourth order scheme was used for advecting these boundaries with the numerical velocity data. By monitoring the center of mass of these fluid boundaries, momentum of each component was calculated and related to the total impulse provided by the vortex ring generator. The results demonstrate that ejected fluid exchanges its momentum mostly with added mass during jet ejection and that the momentum of the entrained fluid at jet termination was < 11% of the total ring impulse in all cases except for the triangular NS case. Following jet termination, momentum exchange was observed between ejected and entrained fluid yielding significant increase in entrained fluid’s momentum. A performance metric was defined relating the impulse from over-pressure developed at the nozzle exit plane during jet ejection to the flow evolution, which increased preferentially with L/D over the range considered. An additional benefit of this study was the identification of the initial (i.e., before jet initiation) location of the fluid to be entrained into the vortex ring.     

Synthesis and pancreatic lipase inhibitory activities of some 1,2,4-triazol-5(3)-one derivatives

In this study, starting from 4-amino-5-(4-chlorobenzyl)-2,4-dihydro-3H-1,2,4-triazole-3-one ( 1 ), the 4-Amino-5-(4-chlorobenzyl)-2-undecyl-2,4-dihydro-3H-1,2,4-triazol-3-one ( 2 ) was first synthesized and this compound was converted to Schiff base derivatives ( 3a-e ). In the second step of the study, the 2-[3-(4-chlorobenzyl)-5-oxo-1-undecyl-1,5-dihydro-4H-1,2,4-triazole-4-yl]-acetohydrazide ( 6 ), which was used as a key product in the synthesis of many heterocyclic compounds was synthesized in four steps, and then this compound was converted into methylidene acetohydrazide ( 7a-e ), thiosemicarbazide ( 8a-e ), and 1,2,4-triazole-5-thione ( 9a-e ) derivatives. Also, in the last part of the study, 1,2,4-triazole-5-thione derivatives were changed into Mannich bases ( 10a-b ) bearing a 4-phenylpiperazine ring. These new compounds were tested with regard to pancreatic lipase (PL) inhibition activity, and compound 3b , 3d , 7d , 8d , and 9d showed a considerable anti-lipase activity at various concentrations. The activity of compounds 7b (IC₅₀ = 1.45 ± 0.12 μM) was the highest in terms of IC₅₀, comparable to that of orlistat, a well-known PL inhibitor used as an antiobesity drug.     

The Wigner molecule in a 2D quantum dot

The charge density and pair correlation function of three interacting electrons confined within a two-dimensional disc-like hard-wall quantum dot are calculated by full numerical diagonalization of the Hamiltonian. The formation of a Wigner molecule in the form of equilateral triangular configuration for electrons is observed as the size of the dot is increased.     

On the Diophantine equation x 2 − kxy + y 2 − 2 n = 0

In this study, we determine when the Diophantine equation x ²?kxy+y ²?2 ⁿ = 0 has an infinite number of positive integer solutions x and y for 0 ? n ? 10. Moreover, we give all positive integer solutions of the same equation for 0 ? n ? 10 in terms of generalized Fibonacci sequence. Lastly, we formulate a conjecture related to the Diophantine equation x ² ? kxy + y ² ? 2 ⁿ = 0.     

Broad band metamaterial absorber based on wheel resonators with lumped elements for microwave energy harvesting

A new metamaterial absorber structure is designed and characterized both numerically and experimentally for microwave energy harvesting applications. The proposed structure includes four wheel resonators with different dimensions, from which the overall response of the structure can then be obtained by summing all the overlapping frequency responses corresponding to each dimension. The essential operation frequency range of the wheels is selected in such a way that the energy used in wireless communications and found within the environment that we live is absorbed. The dimensions are obtained using parametric study and genetic algorithm to realize wideband absorption response. When the simulation and measurement results are taken into account, it is observed that the metamaterial absorber based harvester has potential to absorb and convert microwave energy with an absorption ratio lying within the range of 80 and 99% for the frequency band of 3–5.9 and 7.3–8 GHz. The conversion efficiency of the structure as a harvester is found to be greater than 0.8 in the interval of 2–5 GHz. Furthermore, the incident angle and polarization dependence of the wheel resonator based metamaterial absorber and harvester is also investigated and it is observed that the structure has both polarization and incident angle independent frequency response with good absorption characteristics in the entire working frequency band. Hence, the suggested design having good absorption, polarization and angle independent characteristics with wide bandwidth is a potential candidate for future energy harvester using wireless communication frequency band.     

Theoretical analysis of atom formation-time curves for the HGA-74 furnace—II: Evaluation of the atomisation mechanisms Mn,Cr and Pb

In this study, a novel approach was used in the evaluation of the atomisation mechanisms of Mn, Cr and Pb. The atomisation process was considered as first order kinetics. The effect of the heating rates, chemical form of analyte, gas flow and analyte mass on the atomisation mechanisms of these elements were investigated. The major pathways leading to gaseous atoms have been found to be the thermal dissociation of the metal oxide and reduction of the metal oxide followed by the vaporisation of free metal.     

A Selective LC Method for the Determination of Reboxetine in Human Plasma with Fluorescence Detection

A rapid, simple, accurate, sensitive and reproducible high performance liquid chromatographic method for the quantitation of reboxetine (REB) in human plasma using fluvoxamine as an internal standard (IS) has been developed and validated. The method is based on derivatization with 7-chloro-4-nitrobenzofurazan (NBD-Cl). The NBD-derivatives in plasma were extracted by liquid–liquid extraction and chromatographed on a reversed phase C₁₈ column with isocratic elution using acetonitrile and aqueous nitric acid (pH 3) solution. Calibration curve was linear over the range 2.0–200.0 ng mL⁻¹ with inter- and intra-assay precision (RSD%) of less than 4%. The mean recovery was about 94% for REB. The applicability of the method to the plasma was also studied.

     

Synthesis of Some N-Alkoxycarbonyl-N″-benzoyl-benzamidrazones（p-toluamidrazones） and 1,3,5-Trisubstituted 1,2,4-Triazole Derivatives from N-Benzoylimidates and their Antimicrobial and Anticancer Screening Studies

Some new N-alkoxycarbonyl-N″-benzoyl-benzamidrazones （p-toluamidrazones） 3a-3d, and 1,3,5-trisubstituted 1,2,4-triazole 4a-4h derivatives by starting from N-benzoylbenzimidates or N-benzoyl-p-toluimidates. The structures of compounds 3 and 4 were established on the basis of elemental analyses, IR, ^1H NMR, ^13C NMR and UV data. Antimicrobial experiments of the compounds performed by using agar-well diffusion and broth microdilution methods revealed that only compounds 3a-3d, 4a and 4b showed inhibitory effect only on Candida albicans ATCC 60193. However, compound 4b had also specific antibacterial activity against Staphylococcus aureus ATCC 25923. The other compounds showed neither antifungal nor antibacterial activities. Compounds 3a, 4a and 4b have been screened on three human tumor cell lines, breast cancer （MCF7）, non small cell lung cancer （NCI-H460）, and CNS cancer （SF-268） at the National Cancer Institute （NCI）, USA, which were found to exhibit low antiproliferative activity.