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81.
Schneider R Ader C Lange A Giller K Hornig S Pongs O Becker S Baldus M 《Journal of the American Chemical Society》2008,130(23):7427-7435
We show that solid-state NMR can be used to investigate the structure and dynamics of a chimeric potassium channel, KcsA-Kv1.3, in lipid bilayers. Sequential resonance assignments were obtained using a combination of (15)N- (13)C and (13)C- (13)C correlation experiments conducted on fully labeled and reverse-labeled as well as C-terminally truncated samples. Comparison of our results with those from X-ray crystallography and solution-state NMR in micelles on the closely related KcsA K (+) channel provides insight into the mechanism of ion channel selectivity and underlines the important role of the lipid environment for membrane protein structure and function. 相似文献
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Olaf Beyersdorff Arne Meier Sebastian M��ller Michael Thomas Heribert Vollmer 《Archive for Mathematical Logic》2011,50(7-8):727-742
Default logic is one of the most popular and successful formalisms for non-monotonic reasoning. In 2002, Bonatti and Olivetti introduced several sequent calculi for credulous and skeptical reasoning in propositional default logic. In this paper we examine these calculi from a proof-complexity perspective. In particular, we show that the calculus for credulous reasoning obeys almost the same bounds on the proof size as Gentzen??s system LK. Hence proving lower bounds for credulous reasoning will be as hard as proving lower bounds for LK. On the other hand, we show an exponential lower bound to the proof size in Bonatti and Olivetti??s enhanced calculus for skeptical default reasoning. 相似文献
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Reaction of the tripodal trilithium triamide [MeSi{SiMe2N(Li)(p‐Tol)}3(thf)2] ( 1 ) with SbCl3 in toluene gave the corresponding triaminostibine [MeSi{SiMe2N(p‐Tol)}3Sb] ( 2 ) in good yield. Its [2,2,2]bicyclooctane‐related cage structure, comprising the trisilylsilane unit and the triamidostibine fragment, was established by a single crystal X‐ray structure analysis: Space group P1, Z = 2, lattice dimensions at 293 K: a = 8.645(4), b = 10.029(5), c = 19.678(9) Å, α = 98.50(3)°, β = 97.46(3)°, γ = 94.80(3)°, R = 0.0216. 相似文献
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Christos Apostolidis Dr. Bernd Schimmelpfennig Dr. Nicola Magnani Dr. Patric Lindqvist‐Reis Dr. Olaf Walter Dr. Richard Sykora Dr. Alfred Morgenstern Dr. Eric Colineau Dr. Roberto Caciuffo Prof. Dr. Reinhardt Klenze Dr. Richard G. Haire Dr. Jean Rebizant Dr. Frank Bruchertseifer Dr. Thomas Fanghänel Prof. Dr. 《Angewandte Chemie (International ed. in English)》2010,49(36):6229-6229
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Olaf Kster Bernd Marx Peter Gemmar Markus M. Hess Hermann Josef Künzel 《Journal of voice》1999,13(3):355-374
High-speed filming is one of the most informative methods for assessing voice physiology data. Tracing high-speed images of the glottis provides quantitative parameters such as the glottal area and the glottal width function. By way of example, a number of studies are discussed which extract quantitative data from high-speed images showing voice onsets. Furthermore, a new computer system (MVAS; multi-dimensional voice analysis system) is presented that synchronously displays a laryngoscopic high-speed film, the electroglottographical signal, and several acoustic analyses of the recorded voice sample. The automatic measurement of glottal width and glottal area from the laryngoscopic images is also provided. Looking at former studies and our analyses of voice onsets reveals a tremendous intersubject and even intrasubject variability (different prephonatory closure, different time span until full amplitude is reached, different open quotient). 相似文献