Thermally induced solid-state transformation of cimetidine. A multi-spectroscopic/chemometrics determination of the kinetics of the process and structural elucidation of one of the products as a stable N3-enamino tautomer

Exposure of cimetidine (CIM) to dry heat (160–180 °C) afforded, upon cooling, a glassy solid containing new and hitherto unknown products. The kinetics of this process was studied by a second order chemometrics-assisted multi-spectroscopic approach. Proton and carbon-13 nuclear magnetic resonance (NMR), as well as ultraviolet and infrared spectroscopic data were jointly used, whereas multivariate curve resolution with alternating least squares (MCR-ALS) was employed as the chemometrics method to extract process information. It was established that drug degradation follows a first order kinetics.     

Compensation for the Influence of Fluctuations in the Distance to the Object During Noncontact Probing in Spectral Domain Optical Coherence Tomography

Radiophysics and Quantum Electronics - We propose and experimentally test a numerical method for correction of the influence of fluctuations in the distance to objects during noncontact probing in...     

X-ray radiography of aluminum cathodes eroded in high-current vacuum arcs

The aim of the study presented in this paper was to characterize quantitatively the erosion of aluminum cathodes in high-current vacuum arcs. The experimental setup comprised two current generators. The first one, capable of generating a current of amplitude up to 350 kA, was used to produce a plasma jet, that is, the object to be investigated. The second generator was used to produce a source of probe radiation for imaging the object under investigation in soft x rays of energy ?ν ≈ 0.5–3 keV. The findings of the study are based on experimental data obtained by electrophysical and radiographic methods. It has been shown that the cathode erosion rate in a high-current vacuum arc is a function of the charge passed through the cathode.     

Synthesis of submicron CaZrO<Subscript>3</Subscript> in combustion reactions

Submicron CaZrO₃ powder is obtained in combustion reactions (solution combustion synthesis—SCS) with glycine. It is found that SCS reduces the sintering temperature of CaZrO₃ powders. The dielectric properties of calcium zirconate ceramics are studied by the electrochemical impedance method. It is shown that a ceramics of powders obtained by the SCS method has high dielectric characteristics.     

Synthesis of new derivatives of α-mangostin (microreview)

Chemistry of Heterocyclic Compounds - This microreview presents the current state of research on functionalization of α-mangostin, a natural hydroxyxanthone. Examples of transformations are...