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排序方式: 共有221条查询结果,搜索用时 15 毫秒
61.
Arulmani Manavalan Manisha Mishra Lin Feng Siu Kwan Sze Hiroyasu Akatsu Klaus Heese 《Experimental & molecular medicine》2013,45(9):e39
This study is aimed at gaining insights into the brain site-specific proteomic senescence signature while comparing physiologically aged brains with aging-related dementia brains (for example, Alzheimer''s disease (AD)). Our study of proteomic differences within the hippocampus (Hp), parietal cortex (pCx) and cerebellum (Cb) could provide conceptual insights into the molecular mechanisms involved in aging-related neurodegeneration. Using an isobaric tag for relative and absolute quantitation (iTRAQ)-based two-dimensional liquid chromatography coupled with tandem mass spectrometry (2D-LC-MS/MS) brain site-specific proteomic strategy, we identified 950 proteins in the Hp, pCx and Cb of AD brains. Of these proteins, 31 were significantly altered. Most of the differentially regulated proteins are involved in molecular transport, nervous system development, synaptic plasticity and apoptosis. Particularly, proteins such as Gelsolin (GSN), Tenascin-R (TNR) and AHNAK could potentially act as novel biomarkers of aging-related neurodegeneration. Importantly, our Ingenuity Pathway Analysis (IPA)-based network analysis further revealed ubiquitin C (UBC) as a pivotal protein to interact with diverse AD-associated pathophysiological molecular factors and suggests the reduced ubiquitin proteasome degradation system (UPS) as one of the causative factors of AD. 相似文献
62.
Application of temperature‐correlated mobility theory for optimizing the MEKC separation of the main lignans from Schisandra Chinensis Fructus and its prescription Yuye Decoction
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Jingyi Liu Nickolaj Jacob Petersen Kai‐Fai Lee Steen Honoré Hansen Lixing Lao Chowing Sze Yanbo Zhang 《Electrophoresis》2014,35(20):2907-2914
63.
Shiwan Cheng Charline Mesquida Ee Mei Gui Pui Sze Cheow Tong Kooi Lee Tang Lin Teo 《Accreditation and quality assurance》2014,19(6):439-443
A proficiency testing (PT) programme on the determination of benzoic acid in orange juice was organised by the Chemical Metrology Laboratory, Health Sciences Authority, Singapore, for the local food testing laboratories. The PT programme used a metrologically traceable assigned value determined by isotope dilution mass spectrometry to assess the performance of the participating laboratories. This paper discusses the reasons and approach to applying metrological principles to determine the assigned value of a PT programme. The procedure undertaken by the Laboratory to prepare a batch of PT sample, conduct homogeneity and stability testings, as well as value assignment, is presented. The discussions also include the estimation of the measurement uncertainties arising from the characterisation, testing for homogeneity and testing for stability of the PT sample. The Coordinator of the PT programme used the assigned value and its associated measurement uncertainty, together with those of the participating laboratories to assess their performances. Statistical tools applied in the performance evaluations are also presented. 相似文献
64.
Keh-Yi Lee Chyi-Jieh Hsieh Jyh-Rou Sze Gwo-Jiunn Jaw 《Fiber and Integrated Optics》1996,15(4):365-371
We investigate the optimal direct coupling from single-mode fibers to Ti:LihbO3, channel waveguides using a very general formula and a heuristic optimization technique in this article. The coupling efficiency of the optical power depends on both the fiber positions and the modal sizes of the incident fields. From our numerical simulation, it is found that the optimal positions of the fiber axes are not in alignment with the peaks of the waveguiding modal fields and that the coupling efficiency can be improved by microlenses. 相似文献
65.
Y. Li Voskoboynikov C.P. Lee S.M. Sze O. Tretyak 《The European Physical Journal B - Condensed Matter and Complex Systems》2002,28(4):475-481
In this article we study the impact of the spin-orbit interaction on the electron quantum confinement for narrow gap semiconductor
quantum dots. The model formulation includes: (1) the effective one-band Hamiltonian approximation; (2) the position- and
energy-dependent quasi-particle effective mass approximation; (3) the finite hard wall confinement potential; and (4) the
spin-dependent Ben Daniel-Duke boundary conditions. The Hartree-Fock approximation is also utilized for evaluating the characteristics
of a two-electron quantum dot system. In our calculation, we describe the spin-orbit interaction which comes from both the
spin-dependent boundary conditions and the Rashba term (for two-electron quantum dot system). It can significantly modify
the electron energy spectrum for InAs semiconductor quantum dots built in the GaAs matrix. The energy state spin-splitting
is strongly dependent on the dot size and reaches an experimentally measurable magnitude for relatively small dots. In addition,
we have found the Coulomb interaction and the spin-splitting are suppressed in quantum dots with small height.
Received 15 May 2001 / Received in final form 14 May 2002 Published online 13 August 2002 相似文献
66.
This study reports the development of novel chiral sensors based on the self-assembly of perfunctionalized beta-cyclodextrins (beta-CD) on a quartz crystal microbalance transducer for real time chiral recognition. Ten chiral sensors immobilized with mercaptyl perfunctionalized beta-cyclodextrins were found to exhibit promising enantioselectivity in the gas phase. Well-defined sizes of molecular cavities of the modified beta-CDs associated with cooperative weak interactions with the host molecules afforded enhanced chiral discrimination. This study contributes to the realization of novel chiral sensors applicable for real-time recognition and analysis of enantiomeric alcohols and lactates. 相似文献
67.
Pu KY Qi XY Yang YL Lu XM Li TC Fan QL Wang C Liu B Chan HS Huang W 《Chemistry (Weinheim an der Bergstrasse, Germany)》2008,14(4):1205-1215
Three new topology-varied rod-coil block copolymers, comprising the same oligo(p-phenyleneethynylene) (OPE) rod components and the same coil components, were synthesized by atom-transfer radical polymerization. Their photophysical properties were systematically studied and compared in consideration of their solid-state structures and self-assembly abilities. These copolymers have similar intrinsic photophysical properties to the OPE rods, as reflected in dilute solution. However, their photophysical properties in the solid state are manipulated to be dissimilar by supramolecular organization. Wide-angle X-ray diffraction (WAXD) and atomic force microscopy (AFM) data demonstrate that these copolymers possess different self-assembly abilities due to the molecular-architecture-dependent pi-pi interactions of the rods. Hence, the aggregates in the solid state are formed with a different mechanism for these copolymers, bringing about the discrepancy in the solid-state luminescent properties. 相似文献
68.
Seok-Zun Song Kyung-Tae Kang LeRoy B. Beasley Nung-Sing Sze 《Linear algebra and its applications》2008,429(1):209-223
An m×n matrix A over a semiring is called regular if there is an n×m matrix G over such that AGA=A. We study the problem of characterizing those linear operators T on the matrices over a semiring such that T(X) is regular if and only if X is. Complete characterizations are obtained for many semirings including the Boolean algebra, the nonnegative reals, the nonnegative integers and the fuzzy scalars. 相似文献
69.
In a recent paper, Neumann and Sze considered for an n × n nonnegative matrix A, the minimization and maximization of ρ(A + S), the spectral radius of (A + S), as S ranges over all the doubly stochastic matrices. They showed that both extremal values are always attained at an n × n permutation matrix. As a permutation matrix is a particular case of a normal matrix whose spectral radius is 1, we consider here, for positive matrices A such that (A + N) is a nonnegative matrix, for all normal matrices N whose spectral radius is 1, the minimization and maximization problems of ρ(A + N) as N ranges over all such matrices. We show that the extremal values always occur at an n × n real unitary matrix. We compare our results with a less recent work of Han, Neumann, and Tastsomeros in which the maximum value of ρ(A + X) over all n × n real matrices X of Frobenius norm was sought. 相似文献
70.
Matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) is rarely used for the analysis of small molecules (< 700 Da) because the low m/z signal is overwhelmed by a high background of matrix ions. We have developed a solution to this problem that employs a novel polymer composite which is formed by covalently cross-linking alpha-cyano-4-hydroxycinnamic acid (HCCA) to SU-8 photoresist via cationic photo-polymerization. Since the HCCA molecules are immobilized, background noise resulting from the matrix ions is significantly reduced or eliminated. Moreover, owing to the hydrophobic surface of the polymer film, the sample spots shrink during solvent evaporation and thus the analytes can be concentrated. As a result, this polymer composite improves detection sensitivity and extends the analyzable species to the low-mass region. The covalent incorporation of HCCA with SU-8 was validated with reflectance FTIR spectroscopy, and the polymer surface was characterized with scanning electron microscopy (SEM). Using MRFA, a small peptide as a standard, 8 mg of HCCA per mL of SU-8 photoresist was found to yield the highest sensitivity and the lowest background noise. Analytes such as peptides or small organic molecules were further examined on this composite surface and no analyte degradation was observed. In a trial of peptide mass fingerprinting of cytochrome c on the composite substrate, the inclusion of low m/z tryptic peptides in the database search dramatically improved the protein identification probability score. 相似文献