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51.
Chun‐Ho Wong Lai‐Sheung Choi Sui‐Lung Yim Dr. Kwun‐Ngai Lau Prof. Dr. Hak‐Fun Chow Sin‐Kam Hui Prof. Dr. Kong‐Hung Sze 《化学:亚洲杂志》2010,5(10):2249-2257
Two series of aliphatic hydrocarbon‐based G1–G3 dendritic 2‐ureido‐4‐pyrimidinones (UPy) ( S‐Gn )2 and ( L‐Gn )2, differing from one another by the distance between the branching juncture to the urea end, were prepared and characterized. These hydrocarbon dendrons were also appended to a p‐aminonitrobenzene solvatochromic chromophore in order to probe their microenvironment polarity. While positive solvatochromism was observed which indicated the chromophore was solvent accessible, there was no significant difference between the microenvironment polarities on going from the G1 to the G3 dendrons. The self‐assembling behavior and tautomeric preference of the dendritic UPy derviatives were examined by 1H NMR spectroscopy. The dimerization constants (Kdim*) of the DDAA tautomers were unchanged at 107 M ?1 in CDCl3 at both 25 and 50 °C, which were comparable to those of UPy compounds bearing other nonpolar substitutents. Furthermore, the lower limits on the K′dim* of the DADA tautomeric forms of the ( S‐Gn )2 and ( L‐Gn )2 series were determined to be 106 and 105 M ?1 in CDCl3, respectively. It was found that a closer proximity of the dendron branching juncture to the UPy unit could lead to a destabilization effect on the dimeric states. Hence, the ( L‐Gn )2 dimers are more stable than those of ( S‐Gn )2 in the DDAA form, but the latter are more stable than the former in the tautomeric DADA state. This study showed that both the highly nonpolar microenvironment and the proximity of the dendritic branching juncture to the UPy motif could alter the strength and profile of the hydrogen bond‐mediated self‐assembling process. 相似文献
52.
In this study, direct surface grafting of nanoporous alumina membranes and glass‐supported alumina films was carried out with three different fluorinated organic acids: trifluoroacetic acid, perfluoropentanoic acid and 2,3,4,5,6‐pentafluorobenzoic acid. Elemental surface composition and chemical environment of alumina were investigated using X‐ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR). Alumina surfaces grafted with fluoro‐organic acids exhibited increased hydrophobic properties compared to ungrafted surfaces when measured using goniometry and atomic force microscopy (AFM). This work describes the evidence for surface chemical modification of alumina using direct reaction with organic acids. An AFM study of the adsorption of the immunoglobulin G (IgG) molecules on the fluoro‐organic‐acid‐grafted surfaces is reported. The results show that an ordered arrangement of immunoglobulin G structures with in‐filling of pores could be achieved only on the more hydrophobic fluoro‐organic‐acid‐grafted alumina membranes. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
53.
Xianzhong Yan Xiangming Kong Youlin Xia Kong Hung Sze Guang Zhu 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2000,147(2):357
Recent developments in the direct observation of J couplings across hydrogen bonds in proteins and nucleic acids provide additional information for structure and function studies of these molecules by NMR spectroscopy. A JNN-correlated [15N, 1H] TROSY experiment proposed by Pervushin et al. (Proc. Natl. Acad. Sci. USA 95, 14147–14151, 1998) can be applied to measure hJHN in smaller nucleic acids in an E.COSY manner. However, it cannot be effectively applied to large nucleic acids, such as tRNATrp, since one of the peaks corresponding to a fast relaxing component will be too weak to be observed in the spectra of large molecules. In this Communication, we proposed a modified JNN-correlated [15N, 1H] TROSY experiment which enables direct measurement of hJHN in large nucleic acids. 相似文献
54.
A general covariant conservation law of energy-momentum in complex general relativity is obtained by way of general displacement transformation in terms of Ashtekar's new variables. The energy is exactly the adm Hamiltonian on the constraint surface on condition that an appropriate time function is chosen. The energy-momentum is gauge covariant and commutes with all the constraints whence they are physical observables. Furthermore, the Poisson brackets of the momentum and the internalSU(2) charges form a 3-Poincaré algebra. 相似文献
55.
Hsiao-Hua K. Burke Nien Dak Sze 《Journal of Quantitative Spectroscopy & Radiative Transfer》1977,17(6):783-793
In this paper, we compare the variational and discrete ordinate methods applied to their simplest representative cases: the 2-step function variational method and the 2-stream approach. It is shown that both methods require minimal computational time. Numerical results of the source functions, intensities and fluxes for the problem of diffuse reflection by different plane-parallel isotropic atmospheres are compared between the two methods. Limitations of both approaches for different single scattering albedos and optical depths are discussed. It is also shown that the variational technique is a more efficient algorithm in handling multi-layer cloud conditions for radiative transfer problems. 相似文献
56.
We have investigated the spectral responsivity of porous silicon Schottky barrier photodetectors in the wavelength range 0.4-1.7 mum . The photodetectors show strong photoresponsivity in both the visible and the infrared bands, especially at 1.55 mum . The photocurrent can reach 1.8 mA at a reverse bias of 6 V under illumination by a 1.55-mum , 10-mW laser diode. The corresponding quantum efficiency is 14.4%. 相似文献
57.
Guneet Kaur Kristiadi Uisan Khai Lun Ong Carol Sze Ki Lin 《Current Opinion in Green and Sustainable Chemistry》2018
The review presents the recent trends in green and sustainable chemistry, as well as waste valorization and their applicability to understand and realize the concept of a circular economy. It also provides a comprehensive global perspective of the linear plastics economy and makes the case for its transformation into a circular plastics economy. Furthermore, bioconversion in a food waste biorefinery to produce fructose as an example of a high value-added product is given as a case study to demonstrate the feasibility of a circular economy. 相似文献
58.
Aqueous two-phase flotation (ATPF), a novel technique which integrates the principles of aqueous two-phase systems and mass transfer mode of solvent sublation, has been successfully applied for the separation and purification of biological materials in the field of biotechnology. From the studies done so far, ATPF has demonstrated as an effective, economical and environment-friendly technique for separation of labile biomolecules from their crude aqueous extracts of natural plants or fermentation broths, under mild separation condition. In this article, the basic principles, experimental apparatus set up, key design variables of ATPF, ATPF applications and a comparative study between ATPF and other conventional methods are discussed. This review is intended to present a comprehensive summary on the research works carried out so far related to ATPF since its introduction in 2009 until present, which will be helpful for further research in ATPF. 相似文献
59.
60.
Arulmani Manavalan Manisha Mishra Lin Feng Siu Kwan Sze Hiroyasu Akatsu Klaus Heese 《Experimental & molecular medicine》2013,45(9):e39
This study is aimed at gaining insights into the brain site-specific proteomic senescence signature while comparing physiologically aged brains with aging-related dementia brains (for example, Alzheimer''s disease (AD)). Our study of proteomic differences within the hippocampus (Hp), parietal cortex (pCx) and cerebellum (Cb) could provide conceptual insights into the molecular mechanisms involved in aging-related neurodegeneration. Using an isobaric tag for relative and absolute quantitation (iTRAQ)-based two-dimensional liquid chromatography coupled with tandem mass spectrometry (2D-LC-MS/MS) brain site-specific proteomic strategy, we identified 950 proteins in the Hp, pCx and Cb of AD brains. Of these proteins, 31 were significantly altered. Most of the differentially regulated proteins are involved in molecular transport, nervous system development, synaptic plasticity and apoptosis. Particularly, proteins such as Gelsolin (GSN), Tenascin-R (TNR) and AHNAK could potentially act as novel biomarkers of aging-related neurodegeneration. Importantly, our Ingenuity Pathway Analysis (IPA)-based network analysis further revealed ubiquitin C (UBC) as a pivotal protein to interact with diverse AD-associated pathophysiological molecular factors and suggests the reduced ubiquitin proteasome degradation system (UPS) as one of the causative factors of AD. 相似文献