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61.
62.
Maria E. Sulbaran Gerzon E. Delgado Asilo J. Mora Ali Bahsas Hector Novoa de Armas Norbert Blaton 《Acta Crystallographica. Section C, Structural Chemistry》2007,63(9):o543-o545
In the title compound, C6H8N2O2S, also known as N‐acetyl‐2‐thiohydantoin–alanine, the molecules are joined by N—H...O hydrogen bonds, forming centrosymmetric R22(8) dimers; these dimers are linked by C—H...O interactions to form R22(10) rings, thus forming C22(10) chains that run along the [101] direction. 相似文献
63.
Braulio Insuasty M
Nica Ramos Jairo Quiroga Adolfo Sanchez Manuel Nogueras Norbert Hanold Herbert Meier 《Journal of heterocyclic chemistry》1994,31(1):61-64
The reaction of 4,5-diamino-1,6-dihydropyrimidin-6-ones 1 with one equivalent of the chalcones 2 leads in an acidic medium to the formation of the 2,4-diaryl-2,3,6,7-tetrahydro-1H-pyrimido[4,5-b][1,4]diazepin-6-ones 3a-m . The structure elucidation of the products is based on detailed nmr investigations including selective 13C[1H] decoupling experiments. 相似文献
64.
Osipov SN Golubev AS Sewald N Michel T Kolomiets AF Fokin AV Burger K 《The Journal of organic chemistry》1996,61(21):7521-7528
A new method for the preparation of alpha-chlorodifluoromethyl-, alpha-bromodifluoromethyl-, and alpha-difluoromethyl-substituted alpha-hydroxy and alpha-amino acid esters 11, 19-21 is described. The key step of the synthesis is the regioselective alkylation of ketones 5, 7-9 and imines 16-18 with C-nucleophiles. The ketones 7-9 are readily available from 3,3,3-trifluorolactate 1 by a five-step procedure. Subsequent removal of the protecting groups from 19-21 provides the corresponding free amino acids 25, 26, 28. 相似文献
65.
On singlet excitation (λ = 254 nm, THF, pentane or hexane), the diastereoisomeric methano-epoxydienes (E)- 6 and (E)- 7 undergo interconversion and yield the products 8 – 11 . The main process is the cleavage of the oxirane ring to the vinyl carbene intermediate e which undergoes addition to the adjacent double bond furnishing the cyclopropene 8 . The alternative carbene intermediate f is evidenced by the formation of the cyclobutene 10 . For the fragmentation leading to 11 , the carbene f as well as the dipolar species h are considered as possible intermediates. On triplet sensitization (acetone, λ > 280 nm), (E)- 7 shows behavior typical of epoxydienes, undergoing fission of the C? O bond of the oxirane ring and isomerization to the compounds 13 , 14 and (E/Z)- 15 . 相似文献
66.
The invariance principle for ϕ-mixing sequences 总被引:1,自引:0,他引:1
Norbert Herrndorf 《Probability Theory and Related Fields》1983,63(1):97-108
Summary In this paper we investigate the invariance principle for -mixing sequences, satisfying restrictions on the variances which are a weak form of stationarity. No mixing rate is assumed. For -mixing strictly stationary sequences we give a necessary and sufficient condition for the invariance principle. 相似文献
67.
Light-induced movement responses of the heterotrichous ciliate Blepharisma japonicum were studied by physiological experiments. Two photosensory responses could be identified. A step-up photophobic response is observed as a very rapid backward movement. Microbeam irradiations of individual cells showed that only the anterior part of the ciliate is able to perceive the light stimulus that mediates the phobic reaction. The action spectrum peaks at approximately 400 nm, which indicates that a blue light receptor is involved.
Positive photokinesis of Blepharisma could be shown as a forward movement that is accelerated by increasing the applied photon fluence rate. The steady state level of the velocity depends highly on wavelength and photon fluence rate of the actinic light. After specific inhibition of the phobic reaction bv 1 m/W NH4 + , photokinesis can be induced by microbeam irradiation at any part of the cell.
We isolated two main pigments by thin layer chromatography and characterized them as hypericin-like compounds: a red pigment that is obviously responsible for the red color of the ciliates (= blepharismin). and a yellow one with maximal absorption near 420 nm. The possible photoreceptor functions of these pigments are discussed.
We could not find in Blepharisma a distinct phototactic behavior which is so typical for the related ciliate Stentor. 相似文献
Positive photokinesis of Blepharisma could be shown as a forward movement that is accelerated by increasing the applied photon fluence rate. The steady state level of the velocity depends highly on wavelength and photon fluence rate of the actinic light. After specific inhibition of the phobic reaction bv 1 m/W NH
We isolated two main pigments by thin layer chromatography and characterized them as hypericin-like compounds: a red pigment that is obviously responsible for the red color of the ciliates (= blepharismin). and a yellow one with maximal absorption near 420 nm. The possible photoreceptor functions of these pigments are discussed.
We could not find in Blepharisma a distinct phototactic behavior which is so typical for the related ciliate Stentor. 相似文献
68.
Norbert Haider Gottfried Heinisch Richard Wanko 《Journal of heterocyclic chemistry》1991,28(5):1441-1444
The utility of the aminonitrile 1 as an educt for the preparation of several new examples of heterocyclefused pyridazines (the [1,2,4]triazolo[1′,5′:1,6]pyrimido[4,5-c]pyridazine 7 , the pyrimido[4,5-c]pyridazines 8, 10a,b , and the pyrido[2,3-c]pyridazine 11 ) is demonstrated. 相似文献
69.
Scott L. Gibson Marwan K. Al-Shawi Alan E. Senior Russell Hilf 《Photochemistry and photobiology》1995,61(4):390-396
Abstract— The effectiveness of photodynamic therapy against P-glycoprotein ATPase activity in multidrug-resistant cells was studied. Chinese hamster ovary AUXB1 (drug-sensitive) and CR1R12 (multidrug-resistant) cell lines were compared with respect to uptake of 14 C-polyhematoporphyrin and porphyrin photosensitization. Phototoxicity of Photofrin® was similar in both cell lines, and no major differences in uptake or efflux of 14 C-polyhematoporphyrin were observed. Porphyrin photosensitization in vitro of CR1R12 cells or isolated plasma membranes from these cells caused inhibition of P-glycoprotein ATPase activity. Application of porphyrin photosensitization at a sublethal level to CR1R12 cells resulted in a small but significant increase in adriamycin-induced cytotoxicity. The hydrophobic "picket-fence" porphyrin, meso -tetrakis-( o -propionamidophenyl)porphyrin,α,α,α,β-isomer, was more inhibitory toward P-glycoprotein ATPase activity than the two less hydrophobic porphyrins tetraphenylporphine tetrasulfonate and Photofrin®. 相似文献
70.
Hans Günther Wahl Silke-Yvonne Habel Norbert Schmieder Hartmut M. Liebich 《Journal of separation science》1994,17(7):543-548
Identification of cis/trans isomers of unsaturated fatty acids cannot usually be achieved by GC-MS (gas chromatography-mass spectrometry) without reference substances. In this study a GC-FTIR-MS system (gas chromatography-Fourier transform-mass spectrometry) was used to identify fatty acid methyl esters (FAMEs) and differentiate between the cis/trans isomers. Besides methyl esters, 2-alkenyl-4,4-dimethyloxazoline derivatives (DMOX), which have been used to locate double bond positions of unsaturated fatty acids, were examined with respect to their suitability for cis/trans differentiation. A combined GC-FTIR-MS system with a wide band (4000–550 cm?1) mercury cadmium telluride (MCT) detector was used in series and parallel to identify 31 reference unsaturated fatty acids, including 7 pairs of cis/trans isomers. Serum samples of healthy persons and commercially available fish oil were analyzed as examples of complex mixtures. Using splitless injection the detection limit for the less sensitive IR detector was 25 ng/μl in case of the weak cis and trans bands. In the FTIR spectra cis/trans isomers were identified by analysis of bands arising from C? H out-of-plane (oop) bending: for both the FAME and DMOX derivatives cis-1,2-disubstituted double bonds give a strong band near 720 cm?1 and the corresponding trans isomers near 967 cm?1. cis Isomers could be identified further by a band at 3012 cm?1. With the combined data of the GC-FTIR-MS system it is now possible to identify polyunsaturated fatty acids with regard to the discrimination of cis/trans isomers. 相似文献