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61.
Despite their simple structure and design, microcantilevers are receiving increased attention due to their unique sensing and actuation features in many MEMS and NEMS. Along this line, a non-linear distributed-parameters modeling of a microcantilever beam under the influence of a nanoparticle sample is studied in this paper. A long-range Van der Waals force model is utilized to describe the microcantilever-particle interaction along with an inextensibility condition for the microcantilever in order to derive the equations of motion in terms of only one generalized coordinate. Both of these considerations impose strong nonlinearities on the resultant integro-partial equations of motion. In order to provide an understanding of non-linear characteristics of combined microcantilever-particle system, a geometrical function is wisely chosen in such a way that natural frequency of the linear model exactly equates with that of non-linear model. It is shown that both approaches are reasonably comparable for the system considered here. Linear and non-linear equations of motion are then investigated extensively in both frequency and time domains. The simulation results demonstrate that the particle attraction region can be obtained through studying natural frequency of the system consisting of microcantilever and particle. The frequency analysis also proves that the influence of nonlinearities is amplified inside the particle attraction region through bending or shifting the frequency response curves. This is accompanied by sudden changes in the vibration amplitude estimated very closely by the non-linear model, while it cannot be predicted by the best linear model at all.  相似文献   
62.
    
Over the past decade, there have been remarkable advances in understanding the signaling pathways involved in cancer development. It is well-established that cancer is caused by the dysregulation of cellular pathways involved in proliferation, cell cycle, apoptosis, cell metabolism, migration, cell polarity, and differentiation. Besides, growing evidence indicates that extracellular matrix signaling, cell surface proteoglycans, and angiogenesis can contribute to cancer development. Given the genetic instability and vast intra-tumoral heterogeneity revealed by the single-cell sequencing of tumoral cells, the current approaches cannot eliminate the mutating cancer cells. Besides, the polyclonal expansion of tumor-infiltrated lymphocytes in response to tumoral neoantigens cannot elicit anti-tumoral immune responses due to the immunosuppressive tumor microenvironment. Nevertheless, the data from the single-cell sequencing of immune cells can provide valuable insights regarding the expression of inhibitory immune checkpoints/related signaling factors in immune cells, which can be used to select immune checkpoint inhibitors and adjust their dosage. Indeed, the integration of the data obtained from the single-cell sequencing of immune cells with immune checkpoint inhibitors can increase the response rate of immune checkpoint inhibitors, decrease the immune-related adverse events, and facilitate tumoral cell elimination. This study aims to review key pathways involved in tumor development and shed light on single-cell sequencing. It also intends to address the shortcomings of immune checkpoint inhibitors, i.e., their varied response rates among cancer patients and increased risk of autoimmunity development, via applying the data from the single-cell sequencing of immune cells.  相似文献   
63.
    
In recent years, the propagation of ultrasonic guided waves (UGW) along the structure to inspect has amply proven to be an excellent strategy for the health monitoring of isotropic and composite structures (SHM—structural health monitoring). For the proper development of the SHM system, the finite element method (FEM) must be mentioned, since the possibility to study the UGW in very complex structures, even characterized by different materials. Successfully locating any possible damage and identifying its severity are key factors in SHM, thus allowing to reduce the design costs. Numerically, the damage can be modeled with several approaches but it is still not clear which is the best solution to accurately reproduce the UGW mechanisms in a faulty structure. The objective of this paper is to study the various effects that different severities of damage can have on UGW propagation. For the scope, various numerical approaches are considered and the results are compared.  相似文献   
64.
    
Neutral and cationic cyclopentadienone (CpO) N‐heterocyclic carbene (NHC) bis‐carbonyl iron(0) complexes bearing, appended to the NHC ligand, either a terminal amino group on the lateral chain, [Fe(η4‐CpO)(CO)2C‐NHC(CH2)nNH2)] with n = 2 ( 2a ) and 3 ( 2b ), or a cationic NMe3+ fragment, [Fe(η4‐CpO)(CO)2C‐NHC(CH2)2NMe3)](I) ( 3 ), were prepared and characterized in terms of their structure, stability and reactivity. The photochemical properties of 2a and 2b were examined both in organic solvents and in water, revealing the photoactivated release of one CO ligand followed by the formation of the chelated complex [Fe(η4‐CpO)(CO)(κ2C,N‐NHC(CH2)2NH2)] ( 4 ), whose molecular structure was confirmed by single crystal X‐ray diffraction studies. This metallacyclization occurs only in the case of 2a , with the ethylene spacer between NHC ring and NH2 group in the lateral chain, allowing the formation of a stable 6‐membered ring. On the other hand, 2b undergoes decomposition upon irradiation. The reactivity in aqueous solutions revealed the chemical speciation of the complexes at different pH and especially under physiological conditions (phosphate buffer solution at pH 7.4 and 37 °C). The lack of data on the biological properties of iron(0) complexes prompted us to preliminarily investigate their cytotoxicity against model cancer cells (AsPC‐1 and HPAF‐II), along with a determination of their lipophilicity.  相似文献   
65.
    
In this contribution, we present a finite element formulation to study elastoplastic structures by using the symplectic Brezis‐Ekeland‐Nayroles (BEN) principle. The approach that provides a minimum principle for the whole trajectories is suitable for dissipative systems dealing with non‐smooth dissipation cases, such as collision, surface friction, viscosity, plasticity, fracture and damage. To derive the variational formulation, the Legendre‐Fenchel transform is performed to establish the null minimisation problem of the power balance. The formalism is specialised to the small strain plasticity and is illustrated by solving a plane strain problem subjected to tensile force. The continuum is discretised with mixed finite element method and implemented into Finite Element Analysis Program (FEAP).  相似文献   
66.
Summary The theory of shocks evolving from weak discontinuities is applied to magnetogasdynamics and worked out in detail for two situations: a spherical disturbance propagating into a uniform magnetic field, and a planar disturbance propagating in the field of a current-carrying wire. For both cases, shock formation is delayed as the magnetoacoustic speed of propagation approaches the Alfvén speed. This agrees with the fact that Alfvén waves do not steepen to form shocks.
Résumé On applique à la magnétogasdynamique la théorie des ondes de choc produites par l'évolution des discontinuités faibles. On présente des résultats sur la formation de chocs par des ondes magnétoacoustiques. Lorsque la vitesse de propagation de ces ondes se rapproche de la vitesse d'Alfvén, l'apparition des chocs est retardée, en accord avec le résultat bien connu que les ondes d'Alfvén ne se transforment pas pour former des chocs.


Research supported in part by Grant No. AFOSR-73-2561.  相似文献   
67.
68.
Electromagnetically induced transparency and polarization conversion due to interference between two polarization-selective plasmonic resonances coexisting in the same planar metamaterial are studied. The metasurface represents a periodic array of two topologically distinct metamolecules combined on the same substrate: i) monopole antennas connected to wires and supporting a high-Q resonance radiatively coupled to x-polarization, and ii) dipolar antennas supporting a low-Q resonance coupled to y-polarization. We demonstrate that due to the interaction between these modes through a capacitive coupling between the metamolecules, one can observe a circularly-polarized Electromagnetically Induced Transparency (EIT) and thereby achieve an efficient ultra-thin quarter-wave plate.  相似文献   
69.
A controversial issue in neurolinguistics is whether basic neural auditory representations found in many animals can account for human perception of speech. This question was addressed by examining how a population of neurons in the primary auditory cortex (A1) of the naive awake ferret encodes phonemes and whether this representation could account for the human ability to discriminate them. When neural responses were characterized and ordered by spectral tuning and dynamics, perceptually significant features including formant patterns in vowels and place and manner of articulation in consonants, were readily visualized by activity in distinct neural subpopulations. Furthermore, these responses faithfully encoded the similarity between the acoustic features of these phonemes. A simple classifier trained on the neural representation was able to simulate human phoneme confusion when tested with novel exemplars. These results suggest that A1 responses are sufficiently rich to encode and discriminate phoneme classes and that humans and animals may build upon the same general acoustic representations to learn boundaries for categorical and robust sound classification.  相似文献   
70.
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