Pressurized-Liquid Extraction as an Efficient Method for Valorization of Thymus serpyllum Herbal Dust towards Sustainable Production of Antioxidants

The aim of this study was to valorize Thymus serpyllum herbal dust, a particular fraction distinguished as an industrial waste from filter-tea production. Pressurized liquid extraction (PLE) was used with the aim of overcoming certain obstacles of conventional extraction techniques in terms of shortening extraction time, reducing solvent consumption and energy costs, using “green” solvents and obtaining high yield and quality products. In order to optimize PLE of T. serpyllum herbal dust, the preliminary screening of the independent variables in order to define the most influential parameters and their domain was done first. After the screening, the optimization study using the face-centered central composite experimental design (CCD) with response surface methodology (RSM) was implemented. Additionally, taking into account the high awareness of the positive influence of antioxidants on the human health and associating it with high content of polyphenolic compounds in various members of Lamiaceae family, PLE has proven to be a great approach for antioxidants recovery from T. serpyllum herbal dust.     

Almost‐spanning universality in random graphs

A graph G is said to be ‐universal if it contains every graph on at most n vertices with maximum degree at most Δ. It is known that for any and any natural number Δ there exists such that the random graph G(n, p) is asymptotically almost surely ‐universal for . Bypassing this natural boundary, we show that for the same conclusion holds when . © 2016 Wiley Periodicals, Inc. Random Struct. Alg., 50, 380–393, 2017     

Multiparameter QKD authentication protocol design over optical quantum channel

Quantum cryptography is the first application of quantum physics at the single photon level. The most important application of quantum cryptography is Quantum Key Distribution (QKD). One of the biggest problems of QKD implementation is enormous number of possible attacks, which puts out specific need for more refined simulation strategies in bridging the gap between theoretic models and their implementation. In this work we have introduced generalized optical architecture which can provide various solutions of some actual problems for two mostly used QKD protocols: BB84 and B92 protocols. Simulations, which included the influence of optical losses over a quantum channel with concrete realistic lengths, have confirmed validity and high level of provable security of the proposed generalized QKD authentication architecture. Due to simplicity of the proposed architecture and obtained QKD B92 protocol communication efficiency, we believe that it can be implemented, solving out some of the most relevant implementation problems which are common for both QKD protocols.     

How black holes form in high energy collisions

Abstract We elucidate how black holes form in trans-Planckian collisions. In the rest frame of one of the incident particles, the gravitational field of the other, which is rapidly moving, looks like a gravitational shock wave. The shock wave focuses the target particle down to a much smaller impact parameter. In turn, the gravitational field of the target particle captures the projectile when the resultant impact parameter is smaller than its own Schwarzschild radius, forming a black hole. One can deduce this by referring to the original argument of escape velocities exceeding the speed of light, which Michell and Laplace used to discover the existence of black holes. Second Award in the 2007 Essay Competition of the Gravity Research Foundation.     

Narrow linewidth, 100 W cw Yb3+-doped silica fiber laser with a point-by-point Bragg grating inscribed directly into the active core

We report on the power scaling to 103 W of a 1.1 microm continuous-wave Yb(3+)-doped silica fiber laser incorporating a point-by-point (PbP) fiber-Bragg grating inscribed directly into the active core using 800 nm femtosecond laser pulses. The spectrum of the laser exhibited a narrow linewidth that broadened to 260 pm at 103 W. The output was frequency doubled using an 11 mm long periodically poled MgO:LiNbO3 crystal to generate 2.1 W of green with an internal conversion efficiency of 10% at high power and 0.81%/W at low power.     

On finite reflexive homomorphism-homogeneous binary relational systems

A structure is called homogeneous if every isomorphism between finitely induced substructures of the structure extends to an automorphism of the structure. Recently, P. J. Cameron and J. Nešet?il introduced a relaxed version of homogeneity: we say that a structure is homomorphism-homogeneous if every homomorphism between finitely induced substructures of the structure extends to an endomorphism of the structure.In this paper, we consider finite homomorphism-homogeneous relational systems with one reflexive binary relation. We show that for a large part of such relational systems (bidirectionally connected digraphs; a digraph is bidirectionally connected if each of its connected components can be traversed by ?-paths) the problem of deciding whether the system is homomorphism-homogeneous is coNP-complete. Consequently, for this class of relational systems there is no polynomially computable characterization (unless P=NP). On the other hand, in case of bidirectionally disconnected digraphs we present the full characterization. Our main result states that if a digraph is bidirectionally disconnected, then it is homomorphism-homogeneous if and only if it is either a finite homomorphism-homogeneous quasiorder, or an inflation of a homomorphism-homogeneous digraph with involution (a specific class of digraphs introduced later in the paper), or an inflation of a digraph whose only connected components are and .     

Solvent Effects on the Structure-Property Relationship of Some Potentially Pharmacologically Active 3-(4-Substituted Benzyl)-5-Ethyl-5-Phenyl- and 3-(4-Substituted Benzyl)-5,5-Diphenylhydantoins

Two series of 3-(4-substituted benzyl)-5-ethyl-5-phenyl- and 3-(4-substituted benzyl)-5,5-diphenylhydantoins were synthesized and their UV absorption spectra were recorded in the region 200–400 nm in selected solvents of different polarity. The effects of solvent dipolarity/polarizability and solvent/solute hydrogen bonding interactions on the spectral shifts were analyzed by means of the linear solvation energy relationship (LSER) methodology of Kamlet and Taft. The quantitative relationships between hydrogen bonding interactions and the lipophilicity and blood-brain permeation of the studied compounds were discussed. Satisfactory linear dependences were obtained for moderate electron-donating and electron-withdrawing substituents at the benzyl moiety, while the strong electron-withdrawing substituent (NO₂) significantly modifies the solvation characteristics of the molecule. The paper clearly demonstrates how the solvatochromic comparison method may be applied to estimate the contributions of various modes of solvation to the pharmaceutically relevant properties of these newly synthetized hydantoin derivatives.     

Using Surface Segregation To Design Stable Ru‐Ir Oxides for the Oxygen Evolution Reaction in Acidic Environments

The methods used to improve catalytic activity are well‐established, however elucidating the factors that simultaneously control activity and stability is still lacking, especially for oxygen evolution reaction (OER) catalysts. Here, by studying fundamental links between the activity and stability of well‐characterized monometallic and bimetallic oxides, we found that there is generally an inverse relationship between activity and stability. To overcome this limitation, we developed a new synthesis strategy that is based on tuning the near‐surface composition of Ru and Ir elements by surface segregation, thereby resulting in the formation of a nanosegregated domain that balances the stability and activity of surface atoms. We demonstrate that a Ru_0.5Ir_0.5 alloy synthesized by using this method exhibits four‐times higher stability than the best Ru‐Ir oxygen evolution reaction materials, while still preserving the same activity.     

Synthesis, characterization and antiproliferative activity of transition metal complexes with 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid (oxaprozin)

A series of novel Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes with oxaprozin (Hoxa), a non-steroidal anti-inflammatory drug, has been synthesized. The drug and complexes have been characterized by elemental and thermogravimetric (TG) analysis, Fourier transform (FT)-IR, 1H-NMR, 13C-NMR, UV-Vis spectroscopy and magnetic susceptibility measurements. The (pseudo)octahedral geometry has been proposed for all complexes based on electronic spectra and magnetic moments. With exception of the Cu(II) complex, where bridging bidentate mode of COO groups has been found, FT-IR spectra confirmed chelately coordinated COO groups in the other complexes. The general formula of the complexes is [M(H2O)2(oxa)2 ·χH2O, with χ=2 for M=Mn, Co and Ni and χ=1.5 for Zn. The binuclear Cu(II) complex, [Cu2(H2O)2(OH)(oxa)3]·2H2O, has strong Cu-Cu interactions of antiferromagnetic type. The complexes and Hoxa did not exhibit the cytotoxic effect to peritoneal macrophages. For the first time these complexes have been tested for their in vitro antiproliferative activity against human colon and breast cancer cell lines, HCT-116 and MDA-231, respectively. For all investigated compounds significant antiproliferative effects have been observed. Ni(II) complex has been shown to be a promising antiproliferative agent exerting excellent activity against HCT-116 even in nanomolar concentrations.