排序方式: 共有206条查询结果,搜索用时 187 毫秒
201.
Somayeh Behrouz Mohammad Navid Soltani Rad Saeid Rostami Marzieh Behrouz Elham Zarehnezhad Ali Zarehnezhad 《Molecular diversity》2014,18(4):797-808
The synthesis and biological effects of 15 novel azole-bonded \(\upbeta \) -hydroxypropyl oxime \(O\) -ethers have been described. In this synthesis, the oximation of aromatic ketones followed by an \(O\) -alkylation reaction with epichlorohydrin and/or epibromohydrin led to the corresponding \(O\) -oxime ether adducts. Subsequently, the attained \(O\) -oxime ether adducts were used to synthesize the target molecules after treating them with the appropriate azole derivatives. The in vitro antifungal and antibacterial activities of title compounds were obtained against several pathogenic fungi, Gram-positive and/or Gram-negative bacteria. Benzophenone \(O\) -2-hydroxy-3-(2-phenyl-1 \(H\) -imidazol-1-yl) propyl oxime and 9 \(H\) -fluoren-9-one \(O\) -2-hydroxy-3-(2-phenyl-1 \(H\) -imidazol-1-yl)propyl oxime proved to have considerable antifungal activity against Candida albicans, Candida krusei, Aspergillus niger, and Trichophyton rubrum. These two compounds demonstrated comparable antifungal activity to clotrimazole and fluconazole (standard drugs). All compounds were also tested against Escherichia coli and Staphylococcus aureus as Gram-negative and Gram-positive bacteria, respectively, and their activities were compared to gentamycin and ampicillin (reference drugs). In general, marginal antibacterial activity against tested bacteria was observed for the title compounds. A molecular docking study is also discussed for the two most potent compounds against fungi. The docking study reveals a considerable interaction between the two most potent compounds and the active site of Mycobacterium P450DM. Moreover, these two compounds are much strongly bound to the active site of Mycobacterium P450DM compared to fluconazole. 相似文献
202.
Behzad Koozegar Kaleji Navid Hosseinabadi 《Journal of Sol-Gel Science and Technology》2014,69(2):412-417
In this work, Sn and Nb co-doped TiO2 were coated on glazed porcelain substrates via sol–gel dip coating method. Field emission-scanning electron microscopy, transmission electron microscopy, and UV–vis spectrophotometer were used to evaluate thickness and optical properties of the thin films. Surface chemical state of thin films was examined by atomic X-ray photoelectron spectroscopy. Water contact angle on the film surfaces was measured by a contact angle analyzer under solar light irradiation. The optical results indicated that Sn/Nb dopant in TiO2 thin film changed the absorption edge from ultraviolet to visible light and exhibited excellent photo-catalytic ability for degradation of methylene blue solution under solar irradiation. Wettability results indicated that Sn and Nb dopant ions had significant effect on the hydrophilicity property of thin films. 相似文献
203.
Gazaleh Imani Shakibaei Hamid Reza Khavasi Peiman Mirzaei Ayoob Bazgir 《Journal of heterocyclic chemistry》2008,45(5):1481-1484
Oxazino[5,6‐f]quinolin‐3‐one derivatives have been synthesized in a one‐pot, and efficient process by condensation of 6‐quinolinol, aromatic aldehydes and urea under microwave‐assisted and thermal solvent‐free conditions. 相似文献
204.
Mohammad Navid Soltani Rad Somayeh Behrouz Ali Khalafi-Nezhad 《Tetrahedron letters》2008,49(7):1115-1120
An efficient and selective method for esterification of alcohols using N-(p-toluenesulfonyl)imidazole (TsIm) is described. In this method, alcohols are refluxed with a mixture of RCO2Na (R: alkyl and aryl), TsIm, and triethylamine in the presence of catalytic amounts of tetra-n-butylammonium iodide (TBAI) in DMF to afford the corresponding esters in good yields. This methodology is highly efficient for various structurally diverse alcohols with selectivity for ROH: 1° > 2° > 3°. 相似文献
205.
Azadeh S. Hashemi Doulabi Hamid Mirzadeh Mohammad Imani Shahriar Sharifi Mohammad Atai Shahram Mehdipour‐Ataei 《先进技术聚合物》2008,19(9):1199-1208
Biodegradable polymers have currently attracted high interest as ideal carriers in drug delivery and tissue engineering applications. In situ forming devices based on these materials will synergistically provide the advantages of the customary prefabricated devices as well as ease of administration. To acheive these objectives, optically transparent and biodegradable macromers based on poly(ethylene glycol) and fumaric acid copolymers were synthesized using propylene oxide as a different proton scavenger to enhance in situ photocrosslinking capability. The macromers in different compositions were then photocured for 300 sec in the presence of a visible light initiator/accelerator couple and also a reactive diluent. Characterization of the macromers and the resulting networks were performed using different spectroscopic, chromatographic, physical, and thermal analysis techniques. The resulted shrinkage strain of the macromers upon photocuring was studied using the bounded disk technique, and initial shrinkage strain rates were obtained by numerical differentiation. Our results suggest that the compositions based on these unsaturated aliphatic polyesters are potentially useful to develop injectable, in situ photocrosslinkable carriers for drug and cell delivery applications. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
206.
Kumar S Choi WT Dong CZ Madani N Tian S Liu D Wang Y Pesavento J Wang J Fan X Yuan J Fritzsche WR An J Sodroski JG Richman DD Huang Z 《Chemistry & biology》2006,13(1):69-79
Chemokines and their receptors play important roles in numerous physiological and pathological processes. To develop natural chemokines into receptor probes and inhibitors of pathological processes, the lack of chemokine-receptor selectivity must be overcome. Here, we apply chemical synthesis and the concept of modular modifications to generate unnatural synthetically and modularly modified (SMM)-chemokines that have high receptor selectivity and affinity, and reduced toxicity. A proof of the concept was shown by transforming the nonselective viral macrophage inflammatory protein-II into new analogs with enhanced selectivity and potency for CXCR4 or CCR5, two principal coreceptors for human immunodeficiency virus (HIV)-1 entry. These new analogs provided insights into receptor binding and signaling mechanisms and acted as potent HIV-1 inhibitors. These results support the concept of SMM-chemokines for studying and controlling the function of other chemokine receptors. 相似文献