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271.
Naveen Kumar Konduru 《合成通讯》2013,43(15):2008-2018
Indium(III) chloride catalyzes regioselective ring opening of chalcone epoxides with nitrogen heterocycles such as indole, 2-methyl indole, and pyrrole under mild conditions at room temperature to afford 1,3-diaryl-2-hydroxy-3-(1H-3-indolyl/2-pyrrolyl)propan-1-ones in good yields (60–88%) within 20–50 min. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. 相似文献
272.
Rabeprazole sodium (Aciphex®) is a gastric proton pump inhibitor used for the prevention and treatment of gastric acid–related diseases. During the synthesis of bulk drug of rabeprazole sodium, we have observed metabolites rabeprazole sulfide and rabeprazole sulfone and related substances rabeprazole-N-oxide, rabeprazole sulfone-N-oxide, N-aralkyl rabeprazole, chloro rabeprazole, and methoxy rabeprazole as impurities in the drug substance. The present work describes the synthesis and characterization of these compounds. 相似文献
273.
274.
Sharma S Dubey NK Dasgupta AK Sahu M Benjamin B Mullangi R Srinivas NR 《Biomedical chromatography : BMC》2012,26(2):232-238
A highly sensitive, rapid assay method has been developed and validated for the estimation of JI-101 in human plasma and urine using LC-MS/MS-ESI in the positive-ion mode. The assay procedure involves extraction of JI-101 and alfuzosin (internal standard, IS) from human plasma/urine with a solid-phase extraction process. Chromatographic resolution was achieved on two Zorbax SB-C(18) columns connected in series with a PEEK coupler using an isocratic mobile phase comprising acetonitrile-0.1% formic acid in water (70:30, v/v). The total run time was 2.0 min. The MS/MS ion transitions monitored were 466.20 → 265.10 for JI-101 and 390.40 → 156.10 for IS. The method was subjected to rigorous validation procedures to cover the following: selectivity, sensitivity, matrix effect, recovery, precision, accuracy, stability and dilution effect. In both matrices the lower limit of quantitation was 10.0 ng/mL and the linearity range extended from ~10.0 to 1508 ng/mL in plasma or urine. The intra- and inter-day precisions were in the ranges 1.57-14.5 and 6.02-12.4% in plasma and 0.97-15.7 and 8.66-10.2% in urine. This method has been successfully applied for the characterization of JI-101 pharmacokinetics in cancer patients. 相似文献
275.
A unit cube in ${\mathbb{R}^k}$ (or a k-cube in short) is defined as the Cartesian product R 1 × R 2?× ... × R k where R i (for 1??? i??? k) is a closed interval of the form [a i , a i + 1] on the real line. A k-cube representation of a graph G is a mapping of the vertices of G to k-cubes such that two vertices in G are adjacent if and only if their corresponding k-cubes have a non-empty intersection. The cubicity of G is the minimum k such that G has a k-cube representation. From a geometric embedding point of view, a k-cube representation of G?=?(V, E) yields an embedding ${f: V(G) \rightarrow \mathbb{R}^k}$ such that for any two vertices u and v, ||f(u) ? f(v)||?? ?? 1 if and only if ${(u, v) \in E(G)}$ . We first present a randomized algorithm that constructs the cube representation of any graph on n vertices with maximum degree ?? in O(?? ln n) dimensions. This algorithm is then derandomized to obtain a polynomial time deterministic algorithm that also produces the cube representation of the input graph in the same number of dimensions. The bandwidth ordering of the graph is studied next and it is shown that our algorithm can be improved to produce a cube representation of the input graph G in O(?? ln b) dimensions, where b is the bandwidth of G, given a bandwidth ordering of G. Note that b ?? n and b is much smaller than n for many well-known graph classes. Another upper bound of b + 1 on the cubicity of any graph with bandwidth b is also shown. Together, these results imply that for any graph G with maximum degree ?? and bandwidth b, the cubicity is O(min{b, ?? ln b}). The upper bound of b?+ 1 is used to derive upper bounds for the cubicity of circular-arc graphs, cocomparability graphs and AT-free graphs in terms of the maximum degree ??. 相似文献
276.
M.G. Murali P. Naveen D. Udayakumar Vandana Yadav Ritu Srivastava 《Tetrahedron letters》2012,53(2):157-161
A new donor–acceptor (D–A) conjugated polymer (PDTOF) containing 3,4-didodecyloxythiophene, fluorene and 1,3,4-oxadiazole units is synthesized by using Wittig reaction methodology. The synthesized polymer is characterized by 1H NMR, FTIR, GPC, and elemental analysis. The optical energy band gap of the polymer is found to be 2.42 eV as calculated from the onset absorption edge. The electrochemical studies of PDTOF reveal that, the HOMO and LUMO energy levels of the polymer are ?5.45 eV and ?3.58 eV, respectively. The polymer is thermally stable up to 320 °C. Polymer light-emitting diode devices are fabricated with a configuration of ITO/PEDOT: PSS/PDTOF/Al using PDTOF as the emissive layer. The electroluminescence (EL) spectrum of the device showed green emission with CIE coordinate values (0.34, 0.47). By current density–voltage characteristics, threshold voltage of the PLED device is found to be 6.5 V. 相似文献
277.
The influence of surface plasma waves on high-order harmonic generation from the interaction of intense lasers with overdense plasma is analyzed. It is shown that the surface waves lead to the emission of harmonics away from the optical axis, whereas the high-order on-axis harmonics are lowered in intensity. Our simulation results indicate that surface plasma wave generation plays a crucial role in surface high-order harmonic generation experiments. Furthermore, a novel surface plasma wave generation process different from the well-known two-surface wave decay is observed in the highly relativistic regime. 相似文献
278.
279.
Haynie DT Balkundi S Palath N Chakravarthula K Dave K 《Langmuir : the ACS journal of surfaces and colloids》2004,20(11):4540-4547
The role of molecular structure, charge, and hydrophobicity in polyelectrolyte layer-by-layer assembly (LbL) of thin films has been studied using the model polypeptides poly-L-glutamatic acid (PLGA) and poly-L-lysine (PLL), quartz crystal microbalance (QCM), and circular dichroism spectroscopy (CD). The adsorption behavior of PLGA and PLL has been compared with the structure of these molecules in aqueous solution under the same conditions. The data show that the deposition of polypeptide per adsorption step scales with average secondary structure content, whether alpha helix or beta sheet. This is contrary to the expectation based on the view that hydrogen bonds are crucial to polypeptide film assembly, because secondary structure formation in a polypeptide reduces its intermolecular hydrogen-bonding potential. The data also show that polypeptide adsorption scales with ionic strength and chain length. Taken together, the results increase knowledge of polypeptide-based LbL thin film fabrication and will help to provide a firmer foundation for the use of natural or designed polypeptides in LbL. 相似文献
280.
D. Naveen Kumar 《Tetrahedron letters》2004,45(41):7713-7714
A chiron approach to a synthesis of (1R,2R,5S,7R)-2-hydroxy-exo-brevicomin 1, a component of the volatiles obtained from male mountain pine beetles, Dendroctonus ponderosae has been achieved. Our synthesis started with commercially available d-mannitol and involved Wittig olefination, acid catalysed one-pot hydrogenation and internal acetalization as key steps. 相似文献