One-pot and stereoselective synthesis of 2,3-dihydro-1,5-benzodiazepin-2-one with a phosphanylidene or phosphono-succinate substituent

The one-pot synthesis of 2,3-dihydro-1,5-benzodiazepins-2-one bearing phosphanylidene (ylide) or phosphono-succinate substituent is described. In this four-component reaction, benzodiazepine derived from condensation of o-phenylenediamine and diketene is trapped with the trialkyl phosphite-dialkyl acetylenedicarboxylate zwitterion. In the presence of H₂O, the ylide functional group is hydrolyzed to the corresponding phosphonate. The configuration of the products is selective and only one of the two possible rotamers or diastereomers is formed exclusively in high yield.     

Multiple criteria facility location problems: A survey

This paper provides a review on recent efforts and development in multi-criteria location problems in three categories including bi-objective, multi-objective and multi-attribute problems and their solution methods. Also, it provides an overview on various criteria used. While there are a few chapters or sections in different location books related to this topic, we have not seen any comprehensive review papers or book chapter that can cover it. We believe this paper can be used as a complementary and updated version.     

Oxidation of Primary Alcohols to Carboxylic Acids Using Silica Supported CrO3/H5IO6 Under Microwave Irradiation in a Solvent‐Free System

Chromium trioxide/periodic acid supported onto wet silica gel oxidizes primary alcohols to the corresponding carboxylic acids in very short reaction times in very good yields.     

Investigation of kinetic and mechanism of triphenylphosphine addition to para‐naphthoquinone

This work reports the results of a kinetic and mechanistic investigations of the addition reaction of triphenylphosphine to para‐naphtoquinone in 1,2‐dichloromethane as solvent. The order of reaction with respect to the reactants was determined using initial rate method, and the rate constant was obtained on the basis of pseudo‐first‐order method. Variable time method using Uv–Vis spectrophotometry (at 400 nm) was utilized for monitoring this addition reaction, for which the following Arrhenius equation was obtained: The resulting activation parameters E_a, ΔH^#, ΔG^#, and ΔS^# at 300 K were 13.63, 14.42, 18.75 kcal mol^?1, and ?14.54 cal mol^?1K^?1, respectively. The results suggest that the reaction is first order with respect to both triphenylphosphine and para‐naphthoquinone. © 2005 Wiley Periodicals, Inc. Int J Chem Kinet 37: 427–433, 2005     

Synthesis,characterization and molecular docking of new C,N‐palladacycles containing pyridinium‐derived ligands: DNA and BSA interaction studies and evaluation as anti‐tumor agents

Four new monomeric Pd (II) complexes with formulas [Pd(C,N)‐(2′‐NH₂C₆H₄)C₆H₄ (N₃)(L)] ( A ), ( B ) and [Pd(C,N)‐C₆H₄CH₂NH(C₄H₉)(N₃)(L)] ( C ), ( D ), [L = isonicotinamide for ( A ) and ( C ), L = 4‐N,N‐dimethylaminopyridine for ( B ) and ( D )] have been synthesized using four initial dimers [Pd₂{(C,N)‐(2′‐NH₂C₆H₄)C₆H₄}₂(μ‐OAc)₂] ( 1 ), [Pd₂{(C,N)‐ (2′‐NH₂C₆H₄)C₆H₄}₂(μ‐N₃)₂] ( 3 ) for A and C , and [Pd₂{(C,N)‐C₆H₄CH₂NH(C₄H₉)}₂(μ‐OAc)₂] ( 2 ) and [Pd₂{(C,N)‐C₆H₄CH₂NH(C₄H₉)}₂(μ‐N₃)₂] ( 4 ) for B and D . Then synthesized complexes have been characterized by Fourier transform‐infrared, NMR spectroscopy and thermal gravimetric‐differential thermal analysis. Furthermore, UV–Vis spectroscopy, fluorescence spectroscopy, circular dichroism (CD) and helix melting temperature measurements have been employed to study the binding interaction of them with calf thymus‐deoxyribonucleic acid (DNA). The results reveal that all synthesized complexes can interact with DNA via groove‐binding mode. Bovine serum albumin (BSA)‐binding studies have been carried out using UV–Vis spectroscopy, emission titration and CD. However, competitive binding studies using warfarin, ibuprofen and digoxin on site markers demonstrated that the complexes bind to different sites on BSA. The results also indicated that the binding site was mainly located within site‐III for complex A , and site‐I for complexes B , C and D of BSA. In addition, molecular docking studies have been executed to determine the binding site of the DNA and BSA with complexes. Eventually, in vitro cytotoxicity of synthesized palladium complexes and cisplatin were carried out against human promyelocytic leukemia cancer (Hela) and breast cancer (MCF‐7) cell lines. Pursuant to the IC₅₀ values, the cytotoxicity of complexes against MCF‐7 was more than Hela.     

Classical limit of the tensor product of holomorphic discrete series representations

For three coadjoint orbits \(\mathcal {O}_1, \mathcal {O}_2\) and \(\mathcal {O}_3\) in \(\mathfrak {g}^*\) , the Corwin–Greenleaf function \(n(\mathcal {O}_1 \times \mathcal {O}_2, \mathcal {O}_3)\) is given by the number of \(G\) -orbits in \(\{(\lambda , \mu ) \in \mathcal {O}_1 \times \mathcal {O}_2 \, : \, \lambda + \mu \in \mathcal {O}_3 \}\) under the diagonal action. In the case where \(G\) is a simple Lie group of Hermitian type, we give an explicit formula of \(n(\mathcal {O}_1 \times \mathcal {O}_2, \mathcal {O}_3)\) for coadjoint orbits \(\mathcal {O}_1\) and \(\mathcal {O}_2\) that meet \(\left( [\mathfrak {k}, \mathfrak {k}] + \mathfrak {p}\right) ^{\perp }\) , and show that the formula is regarded as the ‘classical limit’ of a special case of Kobayashi’s multiplicity-free theorem (Progr. Math. 2007) in the branching law to symmetric pairs.     

Effect of morphology of thin DNA films on the electron stimulated desorption of anions

We present a comparison between the electron stimulated desorption (ESD) of anions from DNA samples prepared by lyophilization (an example of poorly organized or nonuniform films) and molecular self-assembly (well-ordered films). The lyophilization (or freeze- drying) method is perhaps the most frequently employed technique for forming DNA films for studies of low-energy electron (LEE) interactions leading to DNA damage; however, this technique usually produces nonuniform films with considerable clustering which may affect DNA configuration and enhance sample charging when the film is irradiated. Our results confirm the general validity of ESD measurements obtained with lyophilized samples, but also reveal limitations of lyophilization for LEE studies on DNA films. Specifically we observe some modulation of structures, associated with dissociative electron attachment, in the anion yield functions from different types of DNA film, confirming that conformational factors play a role in the LEE induced damage to DNA.