A Simple and Rapid Stability Indicating LC Determination of Ciprofloxacin Hydrochloride as a Bulk Drug and from Formulations

The present research work discusses the development of a stability indicating reversed phase LC method for determination of ciprofloxacin hydrochloride as a bulk drug and from formulations. The mobile phase selected was water-acetonitrile-triethylamine 75:25:0.1 (v/v/v) adjusted to pH 4.0 with o-phosphoric acid. The calibration curve of the drug was linear in the range 0.25–15 μg mL^?1. The method was accurate and precise with limits of detection and quantitation of 8.01 and 26.7 ng, respectively. Mean percent recovery was 100.71%. The method was used for analysis of ciprofloxacin hydrochloride from pharmaceutical formulations in the presence of its degradation products and commonly used excipients.     

A novel dual-nano assisted synthesis of symmetrical disulfides from aryl/alkyl halides

Here, we have reported a novel approach towards dual-nano assisted synthesis of disulfides from coupling of alkyl/aryl halides and sulfur nanoparticles. The indium oxide nanoparticles as catalyst expedite the conversion and sulfur nanoparticle notably enhances the miscibility, providing a faster, high yielding and cost-effective process in ethanol-water system. The method has synthetic advantages in terms of mild reaction framework, catalyst regeneration, and absence of any sulfide or polysulfide linkage as by-product leading to a column free synthesis. A variety of alkyl, aryl and heteroaryl symmetrical disulfides are obtained in good to excellent yields up to exceeding 98%.     

Colorimetric probes based on anthraimidazolediones for selective sensing of fluoride and cyanide ion via intramolecular charge transfer

Probes based on anthra[1,2-d]imidazole-6,11-dione were designed and synthesized for selective ion sensing. Each probe acted as strong colorimetric sensors for fluoride and cyanide ions and exhibited intramolecular charge transfer (ICT) band, which showed significant red-shifts after addition of either the F(-) or CN(-) ion. One of the probes (2) showed selective colorimetric sensing for both cyanide and fluoride ions. In organic medium, 2 showed selective color change with fluoride and cyanide, whereas in aqueous organic medium it showed a ratiometric response selectively for cyanide ion.     

Synthesis and characterization of some bis(cyclopentadienyl)titanium(IV) complexes with internally functionalized oximes(LH): sol–gel transformations of Cp2TiCl2, Cp2TiClL and Cp2TiL2 to nano‐sized anatase titania

Some bis(cyclopentadienyl)titanium(IV) complexes of the type [Cp₂TiCl_2?n{L}_n] {where, n = 1 or 2; L = ONC(R)Ar; R = H or CH₃ and Ar = C₅H₄N‐2, C₄H₃O‐2 or C₄H₃S‐2} have been synthesized by the metathetical reactions of Cp₂TiCl₂ with the sodium salt of internally functionalized oximes in 1:1 and 1:2 stoichiometry in anhydrous THF. All these red to brown colored solid derivatives have been characterized by elemental analyses, FT‐IR and NMR (¹H and ¹³C{¹H}) spectral studies. The FAB mass spectra of some representative derivatives indicate their monomeric nature. Oximato ligands in all the complexes appear to bind the titanium via N and O in a dihapto ( ‐N, O) manner in the solid state. Thermogravimetric curves of [Cp₂TiCl{ONC(CH₃)C₅H₄N‐2}] and [Cp₂Ti{ONC(CH₃)C₅H₄N‐2}₂] suggest the formation of hybrid materials CpTiO(Cl) and Cp₂TiO, respectively, as the final products at 900 °C under nitrogen atmosphere. Sol–gel transformations of Cp₂TiCl₂, [Cp₂TiCl{ONC(CH₃)C₅H₄N‐2}] and [Cp₂Ti{ONC(CH₃)C₅H₄N‐2}₂] yielded titania a–c, respectively, at low sintering temperature (600 °C). The powder XRD patterns, IR as well as Raman spectra of all these oxides indicate the formation of nano‐sized anatase phase. The SEM images of titania a–c indicate agglomers like surface morphologies. The absorption spectra of a–c exhibit an energy band gap in the range of 3.47–3.71 eV. Copyright © 2011 John Wiley & Sons, Ltd.     

Collisionless stopping of electron current in an inhomogeneous electron magnetohydrodynamics plasma

A brief review of a recent work on a novel collisionless scheme for stopping electron current pulse in plasma is presented. This scheme relies on the inhomogeneity of the plasma medium. This mechanism can be used for heating an overdense regime of plasma where lasers cannot penetrate. The method can ensure efficient localized heating at a desired location. The suitability of the scheme to the frontline fast ignition laser fusion experiment has been illustrated.     

Little Hankel operators on the half plane

In this paper we consider a class of weighted integral operators onL ² (0, ) and show that they are unitarily equivalent to Hankel operators on weighted Bergman spaces of the right half plane. We discuss conditions for the Hankel integral operator to be finite rank, Hilbert-Schmidt, nuclear and compact, expressed in terms of the kernel of the integral operator. For a particular class of weights these operators are shown to be unitarily equivalent to little Hankel operators on weighted Bergman spaces of the disc, and the symbol correspondence is given. Finally the special case of the unweighted Bergman space is considered and for this case, motivated by approximation problems in systems theory, some asymptotic results on the singular values of Hankel integral operators are provided.     

Template Mediated Hybrid from Dendrimer

Novel dendrimer-titania hybrids were prepared in this work from hydroxy and amine terminated polyamidoamine dendrimer (PAMAM generation 4) and titanium alkoxide by an in-situ sol-gel process in presence of a ligand. Dendritic polymers are chosen because of their unique architectural features. Such dendrimer nanocomposite (DNC) can then be used for optical, catalytic, biomedical applications. The hybrid material formed in situ is found to be transparent, brittle and yellow in colour. The hybrids show higher thermal stability than their organic precursors. This is due to enhanced interaction of the inorganic material with the dendrimer through hydrogen bonding as evidenced by PA-FTIR. XPS studies show predominantly the existence of tetravalent titanium due to titania formation.     

VALIDITY AND APPLICABILITY OF TWO SIMPLE HYSTERESIS MODELS TO ASSESS PROGRESSIVE SEISMIC DAMAGE IN R/C ASYMMETRIC BUILDINGS

The coupled lateral-torsional vibration in R/C asymmetric structures under seismic loading leads to larger lateral deformation in the load-resisting elements located at one edge, compared to the other resisting elements. This may cause earlier yielding of the elements of that edge in localized form. Strength and stiffness degradation due to successive inelastic excursions of these R/C structural elements at one edge may make these elements more flexible and weaker as compared to those at the opposite edge. This may cause progressive shifting of stiffness and strength centres away from this flexible edge, leading to consequent increase of effective eccentricity in successive loading cycles. This, in turn, causes a progressive increase in torsional effect in R/C structures. This damaging effect cannot be predicted by using the bilinear hysteresis models devoid of degradation characteristics. Existing sophisticated hysteresis models representing the degrading behaviour of the R/C structural load-resisting elements require a number of parameters to be specified, the evaluation of which requires extremely case-specific calibration study. In this context, the present paper studies the suitability of two alternative simplified hysteresis models, which are capable of predicting the strength and stiffness degrading behaviours with simple input parameters. Responses of idealized asymmetric R/C building systems are studied using these two hysteresis models under design spectrum-consistent synthetic ground motions and idealized near-fault ground motions. The comparison between the responses of the R/C asymmetric structures with deteriorating structural elements and the similar structures having elasto-plastic structural elements proves the suitability of the proposed models in recognizing the progressive damaging effect of torsion in R/C asymmetric buildings.     

Root mean square radii of heavy flavoured mesons in a quantum chromodynamics potential model

We report the results of root mean square (r.m.s.) radii of heavy flavoured mesons in a QCD model with the potential V(r)=?(4α_s/3r) + br + c. As the potential is not analytically solvable, we first obtain the results in the absence of confinement and Coulomb terms respectively. Confinement and Coulomb effects are then introduced successively in the approach using the Dalgarno’s method of perturbation. We explicitly consider the following two quantum mechanical aspects in the analysis: (a) The scale factor c in the potential should not effect the wave function of the system even while applying the perturbation theory. (b) Choice of perturbative piece of the Hamiltonian (confinement or linear) should determine the effective radial separation between the quarks and antiquarks. The results are then compared with the available theoretical values of r.m.s. radii.     

Probing of complete and incomplete fusion dynamics in heavy-ion collision

Three different types of experiments have been performed to explore the complete and incomplete fusion dynamics in heavy-ion collisions. In this respect, first experiment for the measurement of excitation functions of the evaporation residues produced in the ²⁰Ne + ¹⁶⁵Ho system at projectile energy ranges ≈2–8 MeV /nucleon has been done. Measured cumulative and direct cross-sections have been compared with the theoretical model code PACE-2, which takes into account only the complete fusion process. It has been observed that, incomplete fusion fraction is sensitively dependent on projectile energy and mass asymmetry between the projectile and the target systems. Second experiment for measuring the forward recoil range distributions of the evaporation residues produced in the ²⁰Ne + ¹⁶⁵Ho system at projectile energy ≈8 MeV /nucleon has been done. It has been observed that, some evaporation residues have shown additional peaks in the measured forwardrecoil range distributions at cumulative thicknesses relatively smaller than the expected range of the residues produced via complete fusion. The results indicate the occurrence of incomplete fusion involving the breakup of ²⁰Ne into ⁴He + ¹⁶O and /or ⁸Be + ¹²C followed by one of the fragments with target nucleus ¹⁶⁵Ho. Third experiment for the measurement of spin distribution of the evaporation residues produced in the ¹⁶O + ¹²⁴Sn system at projectile energy ≈6 MeV /nucleon, showed that the residues produced as incomplete fusion products associated with fast α and 2 α-emission channels observed in the forward cone, are found to be distinctly different from those of the residues produced as complete fusion products. The spin distribution of the evaporation residues also inferred that in incomplete fusion reaction channels input angular momentum (J ₀) increases with fusion incompleteness when compared to complete fusion reaction channels. Present observation clearly shows that the production of fast forward α-particles arises from relatively larger angular momentum in the entrance channel leading to peripheral collision.