Physicochemical Characterization of PHBV Nanoparticles Functionalized with Multiple Bioactives Designed to be Theranostics for Lung Cancer

Journal of Cluster Science - Lung cancer is a neoplasm associated with bacterial infections, main reason, to design a combined chemotherapy and antimicrobial treatment. Due to adverse drug...     

Ring opening of chiral 2-(1-aminoalkyl)epoxides by aliphatic thiols with total selectivity: synthesis of enantiopure 3-amino-1-(alkylthio)alkan-2-ols

We have studied the thiolysis of (2R,1′S)- or (2S,1′S)-2-(1-aminoalkyl)epoxides 1 or 2 in the presence of BF₃·OEt₂. The ring opening took place at C-3 with complete regioselectivity, affording the corresponding enantiopure (2R,3S)- or (2S,3S)-3-amino-1-(alkylthio)alkan-2-ols 3 or 4 in good or high yield. The structures of compounds 3 and 4 have been proposed based on HMBC NMR experiments.     

Fluoro-Julia olefination as a mild, high-yielding route to alpha-fluoro acrylonitriles

Synthesis of a novel, stable reagent (1,3-benzothiazol-2-ylsulfonyl)fluoroacetonitrile from readily synthesized ethyl alpha-(1,3-benzothiazol-2-ylsulfanyl)-alpha-fluoroacetate is reported. Aldehydes undergo condensations with (1,3-benzothiazol-2-ylsulfonyl)fluoroacetonitrile in the presence of DBU leading to alpha-fluoro acrylonitriles in high yields and with good Z-stereoselectivity. Lowering of reaction temperature increases the Z selectivity.     

Pulse radiolysis of pyridine and methylpyridines in aqueous solutions

The radicals formed from pyridine, 3-methylpyridine, 3,5-dimethylpyridine, 2,6-dimethylpyridine and 2,4,6-trimethylpyridine by attack of H, e^-_aq, OH and O^•- in acqueous solutions were investigated by pulse radiolysisin the pH-range 1–13.8. The UV-vis. absorption spectra as well as the formation and decay kinetics for the protonated and unprotonated forms of the methylpyridine radicals studied are presented. The pK_a-values for the OH-adducts were determined.