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排序方式: 共有173条查询结果,搜索用时 93 毫秒
101.
Ian Whitacre Jessica Pierson BishopLisa L.C. Lamb Randolph A. PhilippBonnie P. Schappelle Melinda L. Lewis 《The Journal of Mathematical Behavior》2012
The purpose of this study was to investigate elementary children's conceptions that might serve as foundations for integer reasoning. Working from an abstract algebraic perspective and using an opposite-magnitudes context that is relevant to children, we analyzed the reasoning of 33 children in grades K-5. We focus our report on three prominent ways of reasoning. We do this by describing and analyzing the responses of three particular children (in Grades 1, 3, and 5) who exemplify these ways of reasoning. We view each of the three ways of reasoning as rich and interesting, and we see relationships of each to formal integer reasoning. At the same time, we view these ways of reasoning in terms of increasing levels of sophistication, potentially belonging to a single learning trajectory. Thus, we see the roots of more sophisticated integer reasoning in children's early intuitions about opposite magnitudes. 相似文献
102.
Darryn Bryant Melinda Buchanan Daniel Horsley Barbara Maenhaut Victor Scharaschkin 《Combinatorica》2011,31(5):507-528
We establish new lower bounds on the pair covering number C
λ
(υ,k) for infinitely many values of υ, k and λ, including infinitely many values of υ and k for λ=1. Here, C
λ
(υ,k) denotes the minimum number of k-subsets of a υ-set of points such that each pair of points occurs in at least λ of the k-subsets. We use these results to prove simple numerical conditions which are both necessary and sufficient for the existence
of (K
k
− e)-designs with more points than blocks. 相似文献
103.
Rongda Xu Melinda ManuelJoshua Cramlett Daniel B. Kassel 《Journal of chromatography. A》2010,1217(10):1616-1625
One of the most commonly performed in vitro ADME assays during the lead generation and lead optimization stage of drug discovery is metabolic stability evaluation. Metabolic stability is typically assessed in liver microsomes, which contain Phase I metabolizing enzymes, mainly cytochrome P450 enzymes (CYPs). The amount of parent drug metabolized by these CYPs is determined by LC/MS/MS. The metabolic stability data are typically used to rank order compounds for in vivo evaluation. We describe a streamlined and intelligent workflow for the metabolic stability assay that permits high throughput analyses to be carried out while maintaining the standard of high quality. This is accomplished in the following ways: a novel post-incubation pooling strategy based on c Log D3.0 values, coupled with ultra-performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS), enables sample analysis times to be reduced significantly while ensuring adequate chromatographic separation of compounds within a group, so as to reduce the likelihood of compound interference. Assay quality and fast turnaround of data reports is ensured by performing automated real-time intelligent re-analysis of discrete samples for compounds that do not pass user-definable criteria during the pooling analysis. Intelligent, user-independent data acquisition and data evaluation are accomplished via a custom visual basic program that ties together every step in the workflow, including cassette compound selection, compound incubation, compound optimization, sample analysis and re-analysis (when appropriate), data processing, data quality evaluation, and database upload. The workflow greatly reduces labor and improves data turnaround time while maintaining high data quality. 相似文献
104.
Strukil V Fábián L Reid DG Duer MJ Jackson GJ Eckert-Maksić M Friščić T 《Chemical communications (Cambridge, England)》2010,46(48):9191-9193
We present a proof-of-principle study of an environmentally-friendly approach to laboratory research, in which the synthesis and structural characterisation of metal-organic complexes and frameworks are achieved without using bulk solvents; our study addresses the use of heteroditopic ligands for manipulating the dimensionality of metal-organic materials and describes how kinetic obstacles in such mechanosynthesis can be overcome. 相似文献
105.
Guanghui Zhu Christopher D. Hoffman Yang Liu Souryadeep Bhattacharyya Dr. Uma Tumuluri Melinda L. Jue Dr. Zili Wu Dr. David S. Sholl Dr. Sankar Nair Dr. Christopher W. Jones Dr. Ryan P. Lively 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(31):10743-10747
Both known and new CC3‐based porous organic cages are prepared and exposed to acidic SO2 in vapor and liquid conditions. Distinct differences in the stability of the CC3 cages exist depending on the chirality of the diamine linkers used. The acid catalyzed CC3 degradation mechanism is probed via in situ IR and a degradation pathway is proposed and supported with computational results. CC3 crystals synthesized with racemic mixtures of diaminocyclohexane exhibited enhanced stability compared to CC3‐R and CC3‐S. Confocal fluorescent microscope images reveal that the stability difference in CC3 species originates from an abundance of mesoporous grain boundaries in CC3‐R and CC3‐S, allowing facile access of aqueous SO2 throughout the crystal, promoting decomposition. These grain boundaries are absent from CC3 crystals made with racemic linkers. 相似文献
106.
Dóra Kelemen Dr. Nóra V. May Dr. Melinda Andrási Prof. Attila Gáspár Prof. István Fábián Dr. Norbert Lihi 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(70):16767-16773
Detailed equilibrium, spectroscopic and superoxide dismutase (SOD) activity studies are reported on a nickel complex formed with a new metallopeptide bearing two nickel binding loops of NiSOD. The metallopeptide exhibits unique nickel binding ability and the binuclear complex is a major species with 2×(NH2,Namide,S−,S−) donor set even in an equimolar solution of the metal ion and the ligand. Nickel(III) species were generated by oxidizing the NiII complexes with KO2 and the coordination modes were identified by EPR spectroscopy. The binuclear complex formed with the binding motifs exhibits superior SOD activity, in this respect it is an excellent model of the native NiSOD enzyme. A detailed kinetic model is postulated that incorporates spontaneous decomposition of the superoxide ion, the dismutation cycle and fast redox degradation of the binuclear complex. The latter process leads to the elimination of the SOD activity. A unique feature of this system is that the NiIII form of the catalyst rapidly accumulates in the dismutation cycle and simultaneously the NiII form becomes a minor species. 相似文献
107.
A novel substrate-directed synthetic route to a series of highly functionalized, orthogonally protected di- or triaminocyclopentanecarboxylate derivatives with multiple chiral centres from an unsaturated bicyclic β-lactam has been accomplished by applying stereoselective ring C–C double bond aziridination with chloramine-T and phenyltrimethylammonium tribromide, followed by regioselective aziridine opening with different N,O nucleophiles and hydrides. The functionalization strategy was successfully extended for access to enantiomerically pure orthogonally protected triaminocarboxylates. 相似文献
108.
109.
AbstractThe synthesis of some highly substituted three-dimensional cyclopentanes with multiple chiral centers and with high regiochemical and stereochemical diversity has been accomplished starting from cyclopentadiene-derived aminocyclopentenecarboxylic acids. The small-molecular design consisted of stereo- and regiocontrolled functionalization of the starting cyclopentene β- and γ-amino acids through oxirane formation/oxirane opening and afforded regio- and diastereoisomers of orthogonally protected aminocyclopentanecarboxylates. 相似文献
110.
Kinetic Control over Pathway Complexity in Supramolecular Polymerization through Modulating the Energy Landscape by Rational Molecular Design
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Dr. Soichiro Ogi Tomoya Fukui Melinda L. Jue Prof. Dr. Masayuki Takeuchi Dr. Kazunori Sugiyasu 《Angewandte Chemie (International ed. in English)》2014,53(52):14363-14367
Far‐from‐equilibrium thermodynamic systems that are established as a consequence of coupled equilibria are the origin of the complex behavior of biological systems. Therefore, research in supramolecular chemistry has recently been shifting emphasis from a thermodynamic standpoint to a kinetic one; however, control over the complex kinetic processes is still in its infancy. Herein, we report our attempt to control the time evolution of supramolecular assembly in a process in which the supramolecular assembly transforms from a J‐aggregate to an H‐aggregate over time. The transformation proceeds through a delicate interplay of these two aggregation pathways. We have succeeded in modulating the energy landscape of the respective aggregates by a rational molecular design. On the basis of this understanding of the energy landscape, programming of the time evolution was achieved through adjusting the balance between the coupled equilibria. 相似文献