A Rationally Designed Bimetallic Platinum (II)-Ferrocene Antitumor Agent Induces Non-Apoptotic Cell Death and Exerts in Vivo Efficacy

Despite phenomenal clinical success, the efficacy of platinum anticancer drugs is often compromised due to inherent and acquired drug resistant phenotypes in cancers. To circumvent this issue, we designed two heterobimetallic platinum (II)-ferrocene hybrids that display multi-pronged anticancer action. In cancer cells, our best compound, 2 , platinates DNA, produces reactive oxygen species, and has nucleus, mitochondria, and endoplasmic reticulum as potential targets. The multi-modal mechanism of action of these hybrid agents lead to non-apoptotic cell death induction which enables circumventing apoptosis resistance and significant improvement in platinum cross resistance profile. Finally, in addition to describing detail mechanistic insights, we also assessed its stability in plasma and demonstrate anticancer efficacy in an in vivo A2780 xenograft model. Strikingly, compared to oxaliplatin, our compound displays better tolerability, safety profile and efficacy in vivo.     

Molecular Interactions of Non-Steroid Anti-Inflammatory Drug Dolonex in Aqueous Solutions of L-Alanine/L-Valine at Different Temperatures: Viscometric Approach

Russian Journal of Physical Chemistry A - The viscosities of aqueous solutions of L-alanine and L-valine with non-steroid anti-inflammatory drug dolonex (0.020, 0.040, 0.060 mol kg–1) have...     

Dyson’s partition ranks and their multiplicative extensions

We study the Dyson rank function N(r, 3; n), the number of partitions of n with rank \(\equiv r \pmod 3\). We investigate the convexity of these functions. We extend N(r, 3; n) multiplicatively to the set of partitions, and we determine the maximum value when taken over all partitions of size n.     

Nonsimilar incompressible laminar boundary layers with magnetic field

The solution of the steady laminar incompressible nonsimilar magneto-hydrodynamic boundary layer flow and heat transfer problem with viscous dissipation for electrically conducting fluids over two-dimensional and axisymmetric bodies with pressure gradient and magnetic field has been presented. The partial differential equations governing the flow have been solved numerically using an implicit finite-difference scheme. The computations have been carried out for flow over a cylinder and a sphere. The results indicate that the magnetic field tends to delay or prevent separation. The heat transfer strongly depends on the viscous dissipation parameter. When the dissipation parameter is positive (i.e. when the temperature of the wall is greater than the freestream temperature) and exceeds a certain value, the hot wall ceases to be cooled by the stream of cooler air because the ‘heat cushion’ provided by the frictional heat prevents cooling whereas the effect of the magnetic field is to remove the ‘heat cushion’ so that the wall continues to be cooled. The results are found to be in good agreement with those of the local similarity and local nonsimilarity methods except near the point of separation, but they are in excellent agreement with those of the difference-differential technique even near the point of separation.     

2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities

All four 2',3'-dideoxy-3'-thio-nucleosides (ddtNTPs) function as substrates for the Y410F mutant of Deep Vent (exo-) DNA polymerase. Not only are the ddtNTPs incorporated to form the N + 1 product, but further elongations are observed in which the key step is attack of the 3'-thiol on the 5'-triphosphate. Although other polymerases are likely to differ in their use of the ddtNTPs, there does not appear to be a fundamental prohibition against using a thiol nucleophile on a phosphate anhydride electrophile. The syntheses of four ddtNTPs (C, T, A, G) are described. [structure: see text]     

A TSC investigation of polymer–polymer contact charging

The transfer of charge across the interface between two materials brought into contact was studied by measuring the small currents produced when layered films composed of two dissimilar films were first heated and then held under isothermal conditions. It was found that, given a fixed electrode orientation, the polarity of the current generally reversed when the relative position of the films were reversed. The sense of the current was in agreement with that expected from the polymer work functions. © 1997 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 35: 2901–2912, 1997     

Sol–gel-assisted synthesis of PVPO-TiO2 nanocomposites extended to bifunctionality as efficient electrode for enzymeless D-( +)-glucose sensing and antimicrobial potential

Journal of Solid State Electrochemistry - A novel polyvinylpyrrolidone oxime and titanium dioxide nanocomposite (PVPO-TiO2 NC)-based enzymeless glucose sensing electrode was fabricated and...