Current perspectives on quinazolines with potent biological activities: A review

Quinazoline is a heterocyclic compound having biological activities. It is aromatic in nature having bicyclic structure containing benzene ring and pyrimidine ring. Quinazoline and its derivatives are found to have wide range of biological activities that is anticancer, analgesic, antimicrobial, antihypertensive, anticonvulsant, antimalarial, antitumor, and anti-tubercular activities. The purpose of this review is to highlight the recent researches made by researchers on various biological activities of quinazoline derivatives on different targets.     

Characterization of BCN films synthesized by radiofrequency plasma enhanced chemical vapor deposition

Boron carbonitride (BCN) films have been synthesized on Si(1 0 0) substrate by radio frequency plasma enhanced chemical vapor deposition using tris-(dimethylamino)borane (TDMAB) as a precursor. The deposition was performed at the different RF powers of 400-800 W, at the working pressure of 2×10⁻¹ Torr. The formation of the sp²-bonded BCN phase was confirmed by Fourier transform infrared spectroscopy. X-ray photoelectron spectroscopy measurements showed that B atoms were bonded to C and N atoms to form the BCN atomic hybrid configurations with the chemical compositions of B₅₂C₁₂N₃₆ (sample 1; prepared at the RF power of 400 W), B₅₂C₁₀N₃₈ (sample 2; at 500 W) and B₄₆C₁₈N₃₆ (sample 3; at 800 W), respectively. Near-edge X-ray absorption fine structure (NEXAFS) measurements indicated that B atoms were bonded not only to N atoms but also to C atoms to form various configurations of sp²-BCN atomic hybrids. The polarization dependence of NEXAFS suggested that the predominant hybrid configuration of sp²-BCN films oriented in the direction perpendicular to the Si substrate.     

Effect of pressure work on free convection flow along a vertical circular cone with suction and variable surface temperature

Free convection laminar flow from a vertical circular cone maintained a variable surface temperature with suction and pressure work effects has been investigated. The governing boundary layer equations are transformed into a non-dimensional form and the resulting nonlinear system of partial differential equations are reduced to local non-similarity equations. The governing non-similarity equations are then solved numerically by implicit finite difference method together with Keller box scheme. Numerical results are presented in terms of velocity and temperature profiles of the fluid as well as the local skin-friction coefficients and the local heat transfer rate for different values of Prandtl number Pr, suction parameter ξ, temperature gradient parameter n and the pressure work parameter ∈. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)     

The effect of number of baffles on the improvement efficiency of primary sedimentation tanks

In this study, the effect of different numbers of baffles is investigated using computational simulation. Laboratory measurements using different numbers of constant height baffles in a rectangular primary sedimentation tank are conducted. The velocity fields measured by an Acoustic Doppler Velocimeter (ADV) are used to verify the results of the computational model. The effects of the number of baffles arrangement on the hydraulic performance of primary settling tanks are studied by using two different ways: the parameters of flow pattern and the Flow Through Curves (FTCs) method. The results of both the experimental and computational investigations indicate that increasing the number of baffles in suitable positions provides minimum volume of the recirculation region, dissipates the kinetic energy, creates a uniform flow field in the tank and finally the hydraulic efficiency of the sedimentation tank will be improved.     

Integer linear programming models for grid-based light post location problem

Selecting optimal location is a key decision problem in business and engineering. This research focuses to develop mathematical models for a special type of location problems called grid-based location problems. It uses a real-world problem of placing lights in a park to minimize the amount of darkness and excess supply. The non-linear nature of the supply function (arising from the light physics) and heterogeneous demand distribution make this decision problem truly intractable to solve. We develop ILP models that are designed to provide the optimal solution for the light post problem: the total number of light posts, the location of each light post, and their capacities (i.e., brightness). Finally, the ILP models are implemented within a standard modeling language and solved with the CPLEX solver. Results show that the ILP models are quite efficient in solving moderately sized problems with a very small optimality gap.     

Effect of high gamma dose on the PADC properties

The effect of the properties of PADC nuclear track detectors after exposure to high doses of gamma absorbed doses up to 5×10⁵ Gray (50 Mrad) were studied. The gamma source was a 9.03 PBq (244 KCi), Co-60 source. Results indicate that each of the bulk etch rate (V_b), the tracks etch rate (V_t) and the sensitivity (V) of the detectors increases with the high gamma absorbed dose, but there is a drop in these parameters at the low gamma absorbed dose. Signs of surface roughness were observed by increasing the gamma absorbed doses and changes in color observed for doses larger than 2×10⁵ Gray. The temperature of detectors during irradiation time reached 41°C. The fission fragment tracks (from Cf-252 source) disappeared quickly within the etching time (minutes) for total absorbed doses greater than 3×10⁵ Gray due to their high bulk etch rate.     

Measurement of the X‐ray mass attenuation coefficients of silver in the 5–20 keV range

The X‐ray mass attenuation coefficients of silver were measured in the energy range 5–20 keV with an accuracy of 0.01–0.2% on a relative scale down to 5.3 keV, and of 0.09–1.22% on an absolute scale to 5.0 keV. This analysis confirms that with careful choice of foil thickness and careful correction for systematics, especially including harmonic contents at lower energies, the X‐ray attenuation of high‐Z elements can be measured with high accuracy even at low X‐ray energies (<6 keV). This is the first high‐accuracy measurement of X‐ray mass attenuation coefficients of silver in the low energy range, indicating the possibility of obtaining high‐accuracy X‐ray absorption fine structure down to the L₁ edge (3.8 keV) of silver. Comparison of results reported here with an earlier data set optimized for higher energies confirms accuracy to within one standard error of each data set collected and analysed using the principles of the X‐ray extended‐range technique (XERT). Comparison with theory shows a slow divergence towards lower energies in this region away from absorption edges. The methodology developed can be used for the XAFS analysis of compounds and solutions to investigate structural features, bonding and coordination chemistry.     

Model spectral function and superconductivity in BaxK1−xBiO3 (x=0.5-0.7)

The Eliashberg spectral density function is constructed for the superconducting compound Ba_xK_1−xBiO₃ with x=0.5, 0.6, 0.7. The functions, besides yielding some prominent structures, show widely spreading spectra that inhibit lattice instability by yielding not too large values of λ(<1.32). The resulting spectral functions show similar shape as other results, where available, and also successfully reproduce the observed critical temperature, isotope exponent, gap ratio and several other parameters.     

Broadband light source based on highly nonlinear non-circular core photonic crystal fiber for medical applications

We present a highly nonlinear non-circular core photonic crystal fiber (HNL-NCPCF) with all normal group velocity dispersion (GVD) to design a supercontinuum (SC) light source for optical coherence tomography (OCT) system. Nonlinear coefficient $\gamma$ is increased as large as 66 W^?1 km^?1 at $1.31\mathrm{\mu }\mathrm{m}$ by reducing the effective mode area and core is made non-circular to increase birefringence by putting the square lattice of air-holes inside the silica host. About 85 nm 10 dB spectral bandwidths for 2.5 ps input optical pulse and 140 nm 10 dB spectral bandwidths for 1.0 ps input optical pulse have been observed using the same fiber length of 200 m and input optical power of 15 W. Coherent lengths of the generated supercontinuum light sources are found $8.91\mathrm{\mu }\mathrm{m}$ for 2.5 ps input optical pulse and $5.41\mathrm{\mu }\mathrm{m}$ for 1.0 ps input optical pulse. Therefore, the highest longitudinal resolution for dental OCT at $1.31\mathrm{\mu }\mathrm{m}$ is found about $3.28\mathrm{\mu }\mathrm{m}$ for tooth enamel.     

Bifurcations and chaos control in a discrete-time predator-prey system of Leslie type

We investigate the dynamics of a discrete-time predator-prey system of Leslie type. We show algebraically that the system passes through a flip bifurcation and a Neimark-Sacker bifurcation in the interior of $\R^{2}_+$ using center manifold theorem and bifurcation theory. Numerical simulations are implimented not only to validate theoretical analysis but also exhibits chaotic behaviors, including phase portraits, period-11 orbits, invariant closed circle, and attracting chaotic sets. Furthermore, we compute Lyapunov exponents and fractal dimension numerically to justify the chaotic behaviors of the system. Finally, a state feedback control method is applied to stabilize the chaotic orbits at an unstable fixed point.