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101.
In this study, slow strain rate tensile testing at elevated temperature is used to evaluate the influence of temperature and strain rate on deformation behaviour in two different austenitic alloys. One austenitic stainless steel (AISI 316L) and one nickel-base alloy (Alloy 617) have been investigated. Scanning electron microscopy related techniques as electron channelling contrast imaging and electron backscattering diffraction have been used to study the damage and fracture micromechanisms. For both alloys the dominante damage micromechanisms are slip bands and planar slip interacting with grain bounderies or precipitates causing strain concentrations. The dominante fracture micromechanism when using a slow strain rate at elevated temperature, is microcracks at grain bounderies due to grain boundery embrittlement caused by precipitates. The decrease in strain rate seems to have a small influence on dynamic strain ageing at 650°C. 相似文献
102.
Ivarsson ME Leroux JC Castagner B 《Angewandte Chemie (International ed. in English)》2012,51(17):4024-4045
Protein toxins constitute the main virulence factors of several species of bacteria and have proven to be attractive targets for drug development. Lead candidates that target bacterial toxins range from small molecules to polymeric binders, and act at each of the multiple steps in the process of toxin-mediated pathogenicity. Despite recent and significant advances in the field, a rationally designed drug that targets toxins has yet to reach the market. This Review presents the state of the art in bacterial toxin targeted drug development with a critical consideration of achieved breakthroughs and withstanding challenges. The discussion focuses on A-B-type protein toxins secreted by four species of bacteria, namely Clostridium difficile (toxins A and B), Vibrio cholerae (cholera toxin), enterohemorrhagic Escherichia coli (Shiga toxin), and Bacillus anthracis (anthrax toxin), which are the causative agents of diseases for which treatments need to be improved. 相似文献
103.
Grunér MS Szilvay GR Berglin M Lienemann M Laaksonen P Linder MB 《Langmuir : the ACS journal of surfaces and colloids》2012,28(9):4293-4300
Hydrophobins are structural proteins produced by filamentous fungi that are amphiphilic and function through self-assembling into structures such as membranes. They have diverse roles in the growth and development of fungi, for example in adhesion to substrates, for reducing surface tension to allow aerial growth, in forming protective coatings on spores and other structures. Hydrophobin membranes at the air-water interface and on hydrophobic solids are well studied, but understanding how hydrophobins can bind to a polar surface to make it more hydrophobic has remained unresolved. Here we have studied different class II hydrophobins for their ability to bind to polar surfaces that were immersed in buffer solution. We show here that the binding under some conditions results in a significant increase of water contact angle (WCA) on some surfaces. The highest contact angles were obtained on cationic surfaces where the hydrophobin HFBI has an average WCA of 62.6° at pH 9.0, HFBII an average of 69.0° at pH 8.0, and HFBIII had an average WCA of 61.9° at pH 8.0. The binding of the hydrophobins to the positively charged surface was shown to depend on both pH and ionic strength. The results are significant for understanding the mechanism for formation of structures such as the surface of mycelia or fungal spore coatings as well as for possible technical applications. 相似文献
104.
Ultrastrong coupling is studied in a modulation-doped parabolic potential well coupled to an inductance-capacitance resonant circuit. In this system, in accordance to Kohn's theorem, strong reduction of the energy level separation caused by the electron-electron interaction compensates the depolarization shift. As a result, a very large ratio of 27% of the Rabi frequency to the center resonance frequency as well as a polariton gap of width 2π × 670 GHz are observed, suggesting parabolic quantum wells as the system of choice in order to explore the ultrastrong coupling regime. 相似文献
105.
106.
A laboratory-scale study on acoustic scattering from a single bubble undergoing dissolution in undersaturated fresh water is presented. Several experiments are performed with the acoustic source driven with five-cycle tone bursts, center frequency of 120 kHz, to insonify a single bubble located on axis of the combined beam of the set of transducers. The bubble is placed on a fine nylon thread located in the far field of the transducer set, arranged in bistatic configuration, in a tank filled with undersaturated water. Backscattered waveforms from the bubble target are acquired every few seconds for several hours until the bubble has completely dissolved, and detailed dissolution curves are produced from the acoustic data. The rate of bubble dissolution is calculated using the solution developed by Epstein and Plesset [J. Chem. Phys. 18, 1505-1509 (1950)]. The results of the experiments performed are in agreement with the calculations. 相似文献
107.
Hans-Jörg G. Diersch Volker Clausnitzer Volodymyr Myrnyy Rodrigo Rosati Mattias Schmidt Holger Beruda Bruno J. Ehrnsperger Raffaele Virgilio 《Transport in Porous Media》2010,83(3):437-464
The flow and deformation processes in swelling porous media are modeled for absorbent hygiene products (e.g., diapers, wipes,
papers etc.). The first part of the article derives the fundamental equations for the hysteretic unsaturated flow, liquid
absorption, and large deformation. The final set of model equations consists of balance equations of mobile and absorbed (immobile)
liquid combined with a series of constitutive relationships. The resulting equation system is strongly nonlinear and requires
advanced numerical strategies for solving. The second part of the article focuses on numerical solution and presents simulation
results for 2D and 3D applications. 相似文献
108.
A method was developed for determination of total iodine content in different standard reference materials (SRMs) and seafood products by inductively coupled plasma/mass spectrometry (ICP/MS). If iodine is present as iodide and nitric acid is used in the wet digestion system, the observed signal is not stable when iodine is measured by ICP/MS at m/z 127. To stabilize the iodine signal, 3% ammonia solution (1 + 1, v/v) was added to the digest. The limit of quantitation of the method, defined as 6 times the standard deviation in the blank solution (n = 20) was estimated to be 15 mg/kg (using 0.2 g dry mass and a dilution factor of 50). The precision, expressed as repeatability of the iodine concentration, varied between 3.2 and 12% in SRMs, with concentrations of 4.70-0.17 mg/kg dry matter. The described method was compared with a method using tetramethylammonium hydroxide extraction. Both methods showed good precision and trueness by analyses of SRMs. The 2 methods were used to determine iodine in seafood from the Barents Sea, the Norwegian Sea, and the North Sea. The results showed great variation between different fish species as well as between individuals within a species. The lowest values of iodine were recorded in muscle of ling (Molva molva) with a mean of 0.07 mg/kg fresh weight and a variation between 0.03 and 0.11 mg/kg fresh weight. The highest values were found in cod (Gadus morhua) from the Barents Sea, with a mean of 2.5 mg/kg and a variation between 0.7 and 12.7 mg/kg fresh weight. 相似文献
109.
Lee J. Silverberg Carlos Pacheco Debashish Sahu Peter Scholl Hany F. Sobhi Joshua T. Bachert Kaitlyn Bandholz Ryan V. Bendinsky Heather G. Bradley Baylee K. Colburn David J. Coyle Jonathon R. Dahl Megan Felty Ryan F. Fox Kyanna M. Gonzalez Jasra M. Islam Stacy E. Koperna Quentin J. Moyer Duncan J. Noble Melissa E. Ramirez Ziwei Yang 《Journal of heterocyclic chemistry》2020,57(4):1797-1805
A series of 11 novel 3-aryl-2-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-ones was prepared at room temperature by T3P-mediated cyclization of N-aryl-C-phenyl imines with thiosalicylic acid. This provides simple and ready access to N-aryl compounds in this family, which have been generally difficult to prepare. 相似文献
110.
Mélodie Ferrat Dr. Kenneth Dahl Dr. Magnus Schou 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(34):8689-8693
Electrophilic 11C-labelled aroyl dimethylaminopyridinium salts, obtained by carbonylative cross-coupling of aryl halides with [11C]carbon monoxide, were prepared for the first time and shown to be valuable intermediates in the synthesis of primary [11C]benzamides. The methodology furnished a set of benzamide model compounds, including the two poly (ADP-ribose) polymerase (PARP) inhibitors niraparib and veliparib, in moderate to excellent radiochemical yields. In addition to providing a convenient and practical route to primary [11C]benzamides, the current method paves the way for future application of [11C]aroyl dimethylaminopyridinium halide salts in positron emission tomography (PET) tracer synthesis. 相似文献