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991.
Lin Zhou Lei Huang Nathalie Bouet Konstantine Kaznatcheev Matthew Vescovi Yifan Dai Shengyi Li Mourad Idir 《Journal of synchrotron radiation》2016,23(5):1087-1090
Surface slope profile is widely used in the metrology of grazing‐incidence reflective optics instead of surface height profile. Nevertheless, the theoretical and experimental model currently used in deterministic optical figuring processes is based on surface height, not on surface slope. This means that the raw slope profile data from metrology need to be converted to height profile to perform the current height‐based figuring processes. The inevitable measurement noise in the raw slope data will introduce significant cumulative error in the resultant height profiles. As a consequence, this conversion will degrade the determinism of the figuring processes, and will have an impact on the ultimate surface figuring results. To overcome this problem, an innovative figuring model is proposed, which directly uses the raw slope profile data instead of the usual height data as input for the deterministic process. In this paper, first the influence of the measurement noise on the resultant height profile is analyzed, and then a new model is presented; finally a demonstration experiment is carried out using a one‐dimensional ion beam figuring process to demonstrate the validity of our approach. 相似文献
992.
993.
Kambiz Farbod Mani Diba Tatiana Zinkevich Stephan Schmidt Matthew J. Harrington Arno P. M. Kentgens Sander C. G. Leeuwenburgh 《Macromolecular bioscience》2016,16(5):717-729
Gelatin nanoparticles can be tuned with respect to their drug loading efficiency, degradation rate, and release kinetics, which renders these drug carriers highly suitable for a wide variety of biomedical applications. The ease of functionalization has rendered gelatin an interesting candidate material to introduce specific motifs for selective targeting to specific organs, but gelatin nanoparticles have not yet been modified to increase their affinity to mineralized tissue. By means of conjugating bone‐targeting alendronate to biocompatible gelatin nanoparticles, a simple method is developed for the preparation of gelatin nanoparticles which exhibit strong affinity to mineralized surfaces. It has been shown that the degree of alendronate functionalization can be tuned by controlling the glutaraldehyde crosslinking density, the molar ratio between alendronate and glutaraldehyde, as well as the pH of the conjugation reaction. Moreover, it has been shown that the affinity of gelatin nanoparticles to calcium phosphate increases considerably upon functionalization with alendronate. In summary, gelatin nanoparticles have been developed, which exhibit great potential for use in bone‐specific drug delivery and regenerative medicine.
994.
Emanuele Frittaion Matthew Hendtlass Alberto Marcone Paul Shafer Jeroen Van der Meeren 《Archive for Mathematical Logic》2016,55(3-4):431-459
A quasi-order Q induces two natural quasi-orders on \({\mathcal{P}(Q)}\), but if Q is a well-quasi-order, then these quasi-orders need not necessarily be well-quasi-orders. Nevertheless, Goubault-Larrecq (Proceedings of the 22nd Annual IEEE Symposium 4 on Logic in Computer Science (LICS’07), pp. 453–462, 2007) showed that moving from a well-quasi-order Q to the quasi-orders on \({\mathcal{P}(Q)}\) preserves well-quasi-orderedness in a topological sense. Specifically, Goubault-Larrecq proved that the upper topologies of the induced quasi-orders on \({\mathcal{P}(Q)}\) are Noetherian, which means that they contain no infinite strictly descending sequences of closed sets. We analyze various theorems of the form “if Q is a well-quasi-order then a certain topology on (a subset of) \({\mathcal{P}(Q)}\) is Noetherian” in the style of reverse mathematics, proving that these theorems are equivalent to ACA0 over RCA0. To state these theorems in RCA0 we introduce a new framework for dealing with second-countable topological spaces. 相似文献
995.
Daniel J. Scott Dr. Nicholas A. Phillips Joshua S. Sapsford Arron C. Deacy Dr. Matthew J. Fuchter Dr. Andrew E. Ashley 《Angewandte Chemie (International ed. in English)》2016,55(47):14738-14742
Despite the rapid development of frustrated Lewis pair (FLP) chemistry over the last ten years, its application in catalytic hydrogenations remains dependent on a narrow family of structurally similar early main‐group Lewis acids (LAs), inevitably placing limitations on reactivity, sensitivity and substrate scope. Herein we describe the FLP‐mediated H2 activation and catalytic hydrogenation activity of the alternative LA iPr3SnOTf, which acts as a surrogate for the trialkylstannylium ion iPr3Sn+, and is rapidly and easily prepared from simple, inexpensive starting materials. This highly thermally robust LA is found to be competent in the hydrogenation of a number of different unsaturated functional groups (which is unique to date for main‐group FLP LAs not based on boron), and also displays a remarkable tolerance to moisture. 相似文献
996.
Nitrosylation of Nitric‐Oxide‐Sensing Regulatory Proteins Containing [4Fe‐4S] Clusters Gives Rise to Multiple Iron–Nitrosyl Complexes 下载免费PDF全文
Pauline N. Serrano Dr. Hongxin Wang Dr. Jason C. Crack Christopher Prior Prof. Matthew I. Hutchings Prof. Andrew J. Thomson Dr. Saeed Kamali Dr. Yoshitaka Yoda Dr. Jiyong Zhao Dr. Michael Y. Hu Dr. Ercan E. Alp Dr. Vasily S. Oganesyan Prof. Nick E. Le Brun Prof. Stephen P. Cramer 《Angewandte Chemie (International ed. in English)》2016,55(47):14575-14579
The reaction of protein‐bound iron–sulfur (Fe‐S) clusters with nitric oxide (NO) plays key roles in NO‐mediated toxicity and signaling. Elucidation of the mechanism of the reaction of NO with DNA regulatory proteins that contain Fe‐S clusters has been hampered by a lack of information about the nature of the iron‐nitrosyl products formed. Herein, we report nuclear resonance vibrational spectroscopy (NRVS) and density functional theory (DFT) calculations that identify NO reaction products in WhiD and NsrR, regulatory proteins that use a [4Fe‐4S] cluster to sense NO. This work reveals that nitrosylation yields multiple products structurally related to Roussin's Red Ester (RRE, [Fe2(NO)4(Cys)2]) and Roussin's Black Salt (RBS, [Fe4(NO)7S3]. In the latter case, the absence of 32S/34S shifts in the Fe?S region of the NRVS spectra suggest that a new species, Roussin's Black Ester (RBE), may be formed, in which one or more of the sulfide ligands is replaced by Cys thiolates. 相似文献
997.
Cover Picture: Darwin's Warm Little Pond: A One‐Pot Reaction for Prebiotic Phosphorylation and the Mobilization of Phosphate from Minerals in a Urea‐Based Solvent (Angew. Chem. Int. Ed. 42/2016) 下载免费PDF全文
998.
Pakorn Wattana-Amorn Waranya Charoenwongsa Christopher Williams Matthew P. Crump 《Natural product research》2016,30(17):1980-1983
Two bioactive cyclic dipeptides, cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr), were isolated from the culture broth of Streptomyces sp. strain 22-4 and tested against three economically important plant pathogens, Xanthomonas axonopodis pv. citri, Ralstonia solanacearum and Clavibacter michiganensis. Both cyclic dipeptides were active against X. axonopodis pv. citri and R. Solanacearum with MIC of 31.25 μg/mL. No activity could be observed against C. michiganensis. 相似文献
999.
Matthew Moore 《Algebra Universalis》2016,75(1):21-31
We show that \({\mathcal {V}(\mathbb {A}(\mathcal {T}))}\) does not have definable principal subcongruences or bounded Maltsev depth. When the Turing machine \({\mathcal {T}}\) halts, \({\mathcal {V}(\mathbb {A}(\mathcal {T}))}\) is an example of a finitely generated semilattice based (and hence congruence \({\wedge}\)-semidistributive) variety with only finitely many subdirectly irreducible members, all finite. This is the first known example of a variety with these properties that does not have definable principal subcongruences or bounded Maltsev depth. 相似文献
1000.
Laboratory experiments are useful for estimating the carbon and nitrogen isotope discrimination factors and turnover rates that are critical for drawing field-based inferences on consumer diets using stable isotopes. Although the utility of these discrimination factors is widely recognized, work in terrestrial systems has largely been limited to studies involving mammals and birds. In contrast, scant attention has been paid to the application of isotopic techniques to reptiles, despite their broad diversity in terms of numbers of species as well as their trophic roles. Here we estimate carbon and nitrogen isotope discrimination factors and turnover for the tree lizard (Urosaurus ornatus) using a diet-switch experiment. Lizards were collected from a C4-dominated grassland and then switched to C3-based diet (crickets) in the laboratory. We estimated discrimination by lizard claw tissue as Δ13C?=?1.2?±?0.1?‰ for carbon and Δ15N?=?0.7?±?0.1?‰ (mean?±?1 SE) for nitrogen, with 95?% turnover occurring after ~15.5 days. These estimates should be appropriate for use in trophic studies of U. ornatus, and possibly other related small-bodied insectivorous lizards. 相似文献