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991.
Ionkin AS Marshall WJ Fish BM Schiffhauer MF Davidson F 《Journal of the American Chemical Society》2007,129(29):9210-9215
A beta-oxaphosphoniumbetaine stabilized by two tert-butyl groups at the phosphonium part of the betaine and two trifluoromethyl groups at the carbon adjoined to the oxa part of the betaine was isolated and structurally characterized. Additional stabilization results from the solvation of the betaine by a parent phosphonium salt, as in 4, or by protonation with methanol, as in 10. According to X-ray analysis, the betaine exhibits a sterically strained "gauche" conformeric form, with torsion angles in the P-C-C-O moiety of 32.2 degrees for 4 and 28.1 degrees for 10. The P...O separations of 3.121 A for 4 and 3.086 A for 10 are just under the sum of the O and P van der Waals radii (3.32 A). The fast H/D exchange of alpha hydrogen atoms to the phosphonium center was observed in the solution of 10 in deuterium oxide and MeOH-d4. The beta-oxaphosphoniumbetaine has long been suspected as an intermediate in the Wittig reaction, but this is the first time a stabilized derivative has been isolated. 相似文献
992.
A stereoselective synthesis of the bis-guanidinium toxin (+)-saxitoxin (STX), the agent infamously associated with red tides and paralytic shellfish poisoning, is described. Our approach to this unique natural product advances through an unusual nine-membered ring guanidine intermediate 39 en route to the tricyclic skeleton that defines STX. The effectiveness of this strategy is notable, as only four steps are needed to transform 39 into the target molecule, including a four-electron alkene oxidation catalyzed by OsCl3. Construction of the critical monocyclic guanidine has been achieved through two channels, the first of which makes use of Rh-catalyzed C-H amination and highlights a novel class of heterocyclic N,O-acetals as iminium ion equivalents for crafting functionalized amines. A second route to 39 relies on a stereoselective acetylide dianion addition to a serine-based nitrone, thereby facilitating the preparation of STX in just 14 linear steps from commercial material. 相似文献
993.
994.
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996.
Rational design and synthesis of catalytically driven nanorotors 总被引:1,自引:0,他引:1
Qin L Banholzer MJ Xu X Huang L Mirkin CA 《Journal of the American Chemical Society》2007,129(48):14870-14871
We report the design and synthesis of nanorotors based upon on-wire lithography. Because of their asymmetric structure, the nanorotors exhibit rotation in a H2O2 bath instead of linear motion. By observing the leading edge of rotation and comparing this result to the nanorotor design, we have concluded that the driving force for motion is dynamic catalytic decomposition of H2O2 which propels, rather than pulls, the nanorotor. 相似文献
997.
998.
We have developed and applied an approach to reaction discovery that takes advantage of DNA encoding, DNA-programmed assembly of substrate pairs, in vitro selection, and PCR amplification, yet does not require reaction conditions that support DNA hybridization. This system allows the simultaneous evaluation of >200 potential bond-forming combinations of substrates in a single experiment and can be applied in a range of solvent and temperature conditions. In an initial application, we applied this system to explore Au(III)-mediated chemistry and uncovered a simple, mild method for the selective Markovnikov-type hydroarylation of vinyl arenes and trisubstituted olefins with indoles. 相似文献
999.
1000.
King BT Körbe S Schreiber PJ Clayton J Nemcova A Havlas Z Vyakaranam K Fete MG Zharov I Ceremuga J Michl J 《Journal of the American Chemical Society》2007,129(43):12960-12980
The 15 symmetrically methylated derivatives of the CB11H12(-) anion (1a) have been synthesized and found to vary greatly in ease of oxidation. Cyclic voltammetry in liquid SO2 yielded fully reversible oxidation potentials for five of those that have no adjacent unsubstituted vertices in positions 7-12; three others showed some indication of reversibility. The anions 1a-16a and the Jahn-Teller distorted neutral radicals 1r-16r have been characterized by ab initio and density functional theory calculations. In the state average CASSCF(13,12)/6-31+G* approximation, the ground state potential energy surface of 1r contains five symmetry-related pairs of minima. The computational results account for the reversible redox potentials very well when the solvent is included explicitly (RI-DFT(BP)/TZVP, COSMO). For display and for a semiquantitative understanding of methyl substituent effects in terms of perturbation theory, the molecular orbitals of 1a have been expressed in the symmetry-adapted cluster basis. The results serve as an underpinning for a set of additive empirical increments for redox potential prediction. Relative to the usual hydrogen standard, a single methyl group facilitates oxidation by approximately 50, 70, 70, and 10 mV in positions 1, 2, 7, and 12, respectively. This electron donor effect on the redox potential is due to a contribution, whereas those of (inductive and direct field) type are negligible. 相似文献