排序方式: 共有55条查询结果,搜索用时 46 毫秒
51.
Maryna V. Kachaeva Diana M. Hodyna Nataliya V. Obernikhina Stepan G. Pilyo Yulia S. Kovalenko Volodymyr M. Prokopenko Oleksiy D. Kachkovsky Volodymyr S. Brovarets 《Journal of heterocyclic chemistry》2019,56(11):3122-3134
A series of new 1,3‐oxazole derivatives, containing in position 5 both donor and acceptor substituents were synthesized. These substances were considered as potentially active anticancer pharmacophores in the human tumor cell line panel derived from nine cancer types, including lung, colon, melanoma, renal, ovarian, brain, leukemia, breast, and prostate. Primary in vitro one‐dose anticancer screening was shown that compounds with acceptor substituents (such as –C(O)OMe, –CN) in the position 5 inhibit the growth of most cell lines, and compounds with donor substituents (such as –NHR, ?SR) in the position 5 do not practically inhibit the growth of cancer cell lines. It can be assumed that the pharmacological activity of 1,3‐oxazole derivatives depends on donor/acceptor nature of the substituents in position 5. It was proposed to evaluate the donor/acceptor ability of 1,3‐oxazole derivatives using the special parameter φ0, which takes into account the relative position of the boundary levels (HOMO end LUMO). The quantum‐chemical modeling was performed; the special parameter φ0 for 1,3‐oxazole derivatives correlates with the experimental results. Quantum‐chemical calculations of the special parameter φ0 allow modeling the pharmacological activity of 1,3‐oxazole derivatives by introducing donor or acceptor substituents at position 2 or 5. This work may be useful for chemists to develop a target synthesis of potential biologically active compounds. 相似文献
52.
P. P. Guranich P. M. Lukach V. V. Tovt E. I. Gerzanich A. G. Slivka V. S. Shusta V. M. Kedyulich 《JETP Letters》2000,71(9):380-382
The dielectric properties of ferroelectric (Sn1?x In(2/3)x )2P2S6 crystals were studied in the region of incommensurate phase transitions occurring upon fast cooling and heating (0.2–11 K/min). The dynamic phase-transition shift observed in these materials was examined. 相似文献
53.
Ornatska M Peleshanko S Genson KL Rybak B Bergman KN Tsukruk VV 《Journal of the American Chemical Society》2004,126(31):9675-9684
We found that the amplification of weak multiple interactions between numerous peripheral branches of irregular, flexible, polydisperse, and highly branched molecules can facilitate their self-assembly into nanofibrillar micellar structures at solid surfaces and the formation of perfect long microfibers in the course of crystallization from solution. The core-shell architecture of the amphiphilic dendritic molecules provides exceptional stability of one-dimensional nanofibrillar structures. The critical condition for the formation of the nanofibrillar structures is the presence of both alkyl tails in the outer shell and amine groups in the core/inner shell. The multiple intermolecular hydrogen bonding and polar interactions between flexible cores stabilize these nanofibers and make them robust albeit flexible. This example demonstrates that one-dimensional supramolecular assembling at different spatial scales (both nanofibers and microfibers) can be achieved without a tedious, multistep synthesis of shape-persistent molecules. 相似文献
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Cemil Ibis Amac Fatih Tuyun Zeliha Ozsoy-Gunes Sibel Sahinler Ayla Maryna V. Stasevych Rostyslav Ya. Musyanovych 《Phosphorus, sulfur, and silicon and the related elements》2013,188(7):955-966
Abstract A novel series of substituted 1,4-naphthoquinone derivatives were synthesized and evaluated for their antibacterial and antifungal activity. The structures of the novel products were characterized by spectroscopic methods. Among the tested compounds, 2,2′,3,3′-alkoxy substituted naphthoquinones, S,O-substituted naphthoquinone, and N,S-substituted naphthoquinone derivatives are the most potent antifungals against C. tenuis. 2,3-Thio-2′,3′-alkoxy substituted naphthoquinones are the most effective antifungal compounds against A. niger. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. 相似文献