全文获取类型
收费全文 | 6091篇 |
免费 | 347篇 |
国内免费 | 54篇 |
专业分类
化学 | 4586篇 |
晶体学 | 44篇 |
力学 | 113篇 |
数学 | 636篇 |
物理学 | 1113篇 |
出版年
2023年 | 24篇 |
2022年 | 67篇 |
2021年 | 117篇 |
2020年 | 94篇 |
2019年 | 110篇 |
2018年 | 96篇 |
2017年 | 90篇 |
2016年 | 200篇 |
2015年 | 186篇 |
2014年 | 218篇 |
2013年 | 377篇 |
2012年 | 430篇 |
2011年 | 506篇 |
2010年 | 307篇 |
2009年 | 238篇 |
2008年 | 404篇 |
2007年 | 352篇 |
2006年 | 360篇 |
2005年 | 304篇 |
2004年 | 286篇 |
2003年 | 242篇 |
2002年 | 213篇 |
2001年 | 109篇 |
2000年 | 103篇 |
1999年 | 73篇 |
1998年 | 53篇 |
1997年 | 52篇 |
1996年 | 62篇 |
1995年 | 54篇 |
1994年 | 51篇 |
1993年 | 33篇 |
1992年 | 36篇 |
1991年 | 26篇 |
1990年 | 38篇 |
1989年 | 37篇 |
1988年 | 30篇 |
1987年 | 23篇 |
1986年 | 20篇 |
1985年 | 42篇 |
1984年 | 29篇 |
1983年 | 22篇 |
1982年 | 27篇 |
1981年 | 26篇 |
1980年 | 20篇 |
1979年 | 30篇 |
1978年 | 19篇 |
1977年 | 24篇 |
1976年 | 22篇 |
1975年 | 18篇 |
1973年 | 27篇 |
排序方式: 共有6492条查询结果,搜索用时 31 毫秒
991.
Xiao SH Reagan JD Lee PH Fu A Schwandner R Zhao X Knop J Beckmann H Young SW 《Combinatorial chemistry & high throughput screening》2008,11(3):195-215
GPCRs had significant representation in the drug discovery portfolios of most major commercial drug discovery organizations for many years. This is due in part to the diverse biological roles mediated by GPCRs as a class, as well as the empirical discovery that they have proven relatively tractable to the development of small molecule therapeutics. Publication of the human genome sequence in 2001 confirmed GPCRs as the largest single gene superfamily with more than 700 members, furthering the already strong appeal of addressing this target class using efficient and highly parallelized platform approaches. The GPCR research platform implemented at Amgen is used as a case study to review the evolution and implementation of available assays and technologies applicable to GPCR drug discovery. The strengths, weaknesses, and applications of assay technologies applicable to G alpha s, G alpha i and G alpha q-coupled receptors are described and their relative merits evaluated. Particular consideration is made of the role and practice of "de-orphaning" and signaling pathway characterization as a pre-requisite to establishing effective screens. In silico and in vitro methodology developed for rapid, parallel high throughput hit characterization and prioritization is also discussed extensively. 相似文献
992.
993.
Choi HC Lee S Lee KK Noda I Park C Kwon CH Jung YM 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2008,69(4):1110-1113
A promising possibility for the quantitative analysis of X-ray absorption near edge structure (XANES) spectra of nanosized electrode materials is demonstrated. We used a 2D map representation technique, which utilizes the values of the first derivatives of the absorbance with respect to the inserted Li(+) content plotted over the two-dimensional space defined by the inserted Li(+) content (mole) versus photon energy (eV) as a single map. The technique was applied to XANES spectra of the Li(y)CoO system in the first Li(+) insertion reaction for determining the structural and electronic variations associated with the change in Li(+) content. The obtained show that the intensities of two peaks at 7725 and 7711 eV increased with the Li(+) content and the difference of intensity change of these two peaks carried out for successive couples of spectra yielded the largest changes at 1.05 and 1.98 mol of Li content. This approach for quantitative analysis of XANES without using conventional simulation techniques enable us to interpret X-ray absorption spectroscopy (XAS) as a quantitative analytical technique with greater confidence. 相似文献
994.
995.
996.
997.
Inokuma Y Easwaramoorthi S Jang SY Kim KS Kim D Osuka A 《Angewandte Chemie (International ed. in English)》2008,47(26):4840-4843
998.
999.
1000.