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31.
Ian K. Webb Marija Mentinova William M. McGee Scott A. McLuckey 《Journal of the American Society for Mass Spectrometry》2013,24(5):733-743
Gas-phase intra-molecular crosslinking of protein ubiquitin cations has been demonstrated via ion/ion reactions with anions of a homobifunctional N-hydroxysulfosuccinimide (sulfo-NHS) ester reagent. The ion/ion reaction between multiply-protonated ubiquitin and crosslinker monoanions produces a stable, charge-reduced complex. Covalent crosslinking is indicated by the consecutive loss of 2 molecules of sulfo-NHS under ion trap collisional activation conditions. Covalent modification is verified by the presence of covalently crosslinked sequence ions produced by ion-trap collision-induced dissociation of the ion generated from the losses of sulfo-NHS. Analysis of the crosslinked sequence fragments allows for the localization of crosslinked primary amines, enabling proximity mapping of the gas-phase 3-D structures. The presence of two unprotonated reactive sites within the distance constraint of the crosslinker is required for successful crosslinking. The ability to covalently crosslink is, therefore, sensitive to protein charge state. As the charge state increases, fewer reactive sites are available and protein structure is more likely to become extended because of intramolecular electrostatic repulsion. At high charge states, the reagent shows little evidence for covalent crosslinking but does show evidence for ‘electrostatic crosslinking’ in that the binding of the sulfonate groups to the protein is sufficiently strong that backbone cleavages are favored over reagent detachment under ion trap collisional activation conditions. 相似文献
32.
Zdravko Džambaski Đorđe Toljić Bojan Bondžić Rade Marković Marija Baranac-Stojanović 《Tetrahedron》2013
The reactivity of 2-alkylidene-4-oxothiazolidine S-oxides under the Pummerer reaction conditions, using Ac2O, TFAA, SOCl2 and SOBr2 as initiators, has been examined. Almost all reactions proceeded with absolute regioselectivity yielding α-substituted sulfides or vinyl-chloro derivatives. The mechanism for the formation of the latter products was postulated and proved experimentally. 相似文献
33.
34.
Marija R. Zoric Usha Pandey Kadel Kirill A. Korvinson Hoi Ling Luk Arunpatcha Nimthong‐Roldan Matthias Zeller Ksenija D. Glusac 《Journal of Physical Organic Chemistry》2016,29(10):505-513
The conformational flexibility of three covalently linked dimers consisting of two xanthene‐based moieties connected by a diphenyl ether linker was studied using NMR spectroscopy, X‐ray crystallography, and density functional theory (DFT) calculations. The three dimers interconvert as a function of pH: the doubly cationic dimer (Xan+)2 exists in acidic solutions (pH < 0.5), the mono‐alcohol monocation Xan+–Xan‐OH at intermediate pH values (pH = 1–3), and the neutral diol at the highest pH‐values (pH > 3). Each dimer exhibits conformational degrees of freedom associated with rotations of either the xanthene moiety or of the diphenyl ether (DPE) linker. The barriers for rotation of the xanthylium moiety were evaluated using DFT calculations, yielding values of 23 kcal/mol for (Xan+)2 and 11 kcal/mol for (Xan‐OH)2, respectively. The rotational barrier for the diphenyl ether linker in Xan+–Xan‐OH (15 kcal/mol) was experimentally determined using variable temperature NMR measurements. The relative orientation of the two –OH groups in (Xan‐OH)2 diol was investigated in solution and the solid state using NMR spectroscopy and X‐ray crystallography. The conformer observed in the solid state was found to be the In–Out conformer, while free rotation of the xanthenol units is thought to occur on the NMR timescale at room temperature. These studies are relevant for the design of linkers for efficient water oxidation catalysts. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
35.
Pfeifer P Aston L Banks M Barker S Burress J Carter S Coleman J Crockett S Faulhaber C Flavin J Gordon M Hardcastle L Kallenborn Z Kemiki M Lapilli C Pobst J Schott R Shah P Spellerberg S Suppes G Taylor D Tekeei A Wexler C Wood M Buckley P Breier T Downing J Eastman S Freeze P Graham S Grinter S Howard A Martinez J Radke D Vassalli T Ilavsky J 《Chaos (Woodbury, N.Y.)》2007,17(4):041108
36.
Evgenija A. Djurendić Olivera R. Klisurić Mihály Szécsi Marija N. Sakač Suzana S. Jovanović-Šanta Imre Ignáth Vesna V. Kojić Aleksandar M. Oklješa Marina P. Savić Katarina M. Penov-Gaši 《Structural chemistry》2014,25(6):1747-1758
Tetrakis-, tris-, bis-, and mono salicylic acid derivatives 1–4 were synthesized by reaction of methyl 2-hydroxy benzoate (methyl salicylate) with 2,2-bis (hydroxymethyl) propane-1,3-diol (pentaerythritol) in the presence of sodium. Yields of different salicyloyloxy derivatives were changed by varying the molar ratios of reactants. For compounds 2 and 3, X-ray structure analysis was performed, as well as molecular energy minimization, to define their conformation in terms of their energy minima. Comparison of crystal and energy minimized structures for these two compounds (2 and 3) revealed that the intramolecular hydrogen bonds play an important role, stabilizing conformation of the most part of the molecule. The antioxidant activity and cytotoxicity of the synthesized derivatives were evaluated in a series of in vitro tests, as well as 17β-hydroxysteroid dehydrogenase type 2 inhibition potency. Tetrakis salicyloyloxy derivative 1 expressed the highest antioxidant potency, tris salicyloyloxy derivative 2 was the best inhibitor of 17βHSD2 enzyme, while bis salicyloyloxy derivative 3 showed strong cytotoxicity against prostate and breast cancer cells with no cytotoxicity against healthy cells. 相似文献
37.
Bojan Ž. Janković Marija M. Janković 《Journal of Thermal Analysis and Calorimetry》2014,115(1):823-832
Isothermal decomposition process of commercial Creosote was analyzed by thermogravimetric technique in a nitrogen atmosphere, at four different operating temperatures (T = 230, 250, 270, and 290 °C). It was found that the two-parameter autocatalytic ?esták–Berggren kinetic model best describes the investigated process. It was established that the applied logistic function can successfully perform a given kinetic predictions of investigated process, at all operating temperatures. The experimental density distribution function of the apparent activation energy values was evaluated. Based of the characteristic shape of distribution curve, it was concluded that the isothermal pyrolysis of commercial Creosote represent a complex process, which probably includes primary and secondary (autocatalytic) pyrolysis reactions, together with various decomposition reactions and radicals recombination pathways. 相似文献
38.
Ana T. Simonović Marija B. Petrović Milan B. Radovanović Snežana M. Milić Milan M. Antonijević 《Chemical Papers》2014,68(3):362-371
This investigation aimed to study a “green” non-toxic biodegradable copper corrosion inhibitor in an acidic sodium sulphate solution. The methods used in the investigation of cysteine as a copper corrosion inhibitor in an acidic sodium sulphate solution were: potentiodynamic measurements, open circuit potential measurements, and chronoamperometric measurements. Optical microscopy was used in addition to electrochemical methods. Potentiodynamic measurements show that cysteine has good inhibitory properties in an acidic medium. Polarisation curves indicate that the presence of cysteine in a sulphate solution decreases the current density and that using various cysteine concentrations results in the formation of a protective film on the surface of the electrode due to the formation of the Cu(I)-cys complex. These results are confirmed by chronoamperometric measurements. Furthermore, it is clear from microphotographs that a protective film does form on copper electrode in the presence of cysteine. The Langmuir adsorption isotherm indicates that cysteine is chemisorbed on the surface of the electrode. 相似文献
39.
Dr. Viktor Pfeifer Marie Certiat Dr. Donia Bouzouita Dr. Alberto Palazzolo Sébastien Garcia-Argote Elodie Marcon David-Alexandre Buisson Dr. Philippe Lesot Prof. Laurent Maron Dr. Bruno Chaudret Dr. Simon Tricard Dr. Iker del Rosal Prof. Romuald Poteau Dr. Sophie Feuillastre Dr. Grégory Pieters 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(22):4988-4996
Ruthenium nanocatalysis can provide effective deuteration and tritiation of oxazole, imidazole, triazole and carbazole substructures in complex molecules using D2 or T2 gas as isotopic sources. Depending on the substructure considered, this approach does not only represent a significant step forward in practice, with notably higher isotope uptakes, a broader substrate scope and a higher solvent applicability compared to existing procedures, but also the unique way to label important heterocycles using hydrogen isotope exchange. In terms of applications, the high incorporation of deuterium atoms, allows the synthesis of internal standards for LC-MS quantification. Moreover, the efficacy of the catalyst permits, even under subatmospheric pressure of T2 gas, the preparation of complex radiolabeled drugs owning high molar activities. From a fundamental point of view, a detailed DFT-based mechanistic study identifying undisclosed key intermediates, allowed a deeper understanding of C−H (and N−H) activation processes occurring at the surface of metallic nanoclusters. 相似文献
40.
Michael Reinhardt Andreas Schnhals Dietmar Pfeifer Karl Pfeiffer Irene V. Lampe Hans-Joachim Lorkowski 《先进技术聚合物》1996,7(10):791-796
Dielectric relaxation spectroscopy in the frequency range from 10−2 Hz to 106 Hz and electron spin resonance (ESR) experiments are employed to study the dynamics in chemically and physically crosslinked networks. As examples for physically crosslinked networks ortho- and para-cresol novolacs were investigated. Dielectrically these materials show low-temperature β- and high-temperature α-relaxation. Both relaxation regions differ for both types of novolacs. This is also reflected by the ESR measurements and is discussed in terms of different hydrogen bonds found to be stronger in para-cresol novolac. For the chemically crosslinked poly(triallyl isocyanurate) only a β-peak is found by the dielectric measurements. Also in the ESR experiment the slow motion regime is characterized up to high temperatures. This means that the segmental motion is strongly suppressed by chemical crosslinking. Nevertheless the obtained change in the formal T50G value can be used to characterize the glass transition in highly crosslinked systems by the ESR method. 相似文献