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61.
Dr. Carlo Fasting Prof. Christoph A. Schalley Dr. Marcus Weber Prof. Oliver Seitz Prof. Stefan Hecht Prof. Beate Koksch Dr. Jens Dernedde Prof. Christina Graf Prof. Ernst‐Walter Knapp Prof. Rainer Haag 《Angewandte Chemie (International ed. in English)》2012,51(42):10472-10498
Multivalent interactions can be applied universally for a targeted strengthening of an interaction between different interfaces or molecules. The binding partners form cooperative, multiple receptor–ligand interactions that are based on individually weak, noncovalent bonds and are thus generally reversible. Hence, multi‐ and polyvalent interactions play a decisive role in biological systems for recognition, adhesion, and signal processes. The scientific and practical realization of this principle will be demonstrated by the development of simple artificial and theoretical models, from natural systems to functional, application‐oriented systems. In a systematic review of scaffold architectures, the underlying effects and control options will be demonstrated, and suggestions will be given for designing effective multivalent binding systems, as well as for polyvalent therapeutics. 相似文献
62.
Daniel Roca‐Sanjuán Marcus Lundberg David A. Mazziotti Roland Lindh 《Journal of computational chemistry》2012,33(26):2124-2126
In the preceding paper results are presented, which are in serious conflict with state‐of‐the‐art ab initio method. Based on these new results the authors propose a new explanation of the reason for the preferential production of a phosphorescent state. Here we show that these controversial results are flawed, since the model use exclude biradical electron structures. © 2012 Wiley Periodicals, Inc. 相似文献
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Tendon injuries are a common problem in medicine. While healthy tendons do not rupture, tendon injuries are mostly accompanied by pathological changes and microruptures. Unfortunately, still less is known about the underlying processes. Thus, in the present study, we introduce artificial damages into native tendon tissue and investigate its mechanical behaviour experimentally. In the second part of this study, we propose a theoretical model for predicting the mechanical behaviour of the damaged tendon and present its validity. (© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
65.
Angela Niedermeyer Bei Zhou Gözde Dursun Marcus Stoffel Aysegül Artmann Bernd Markert 《PAMM》2016,16(1):99-100
Replacement tissues, designed to fill in articular cartilage defects, should exhibit the same properties as the native material. The aim of this study is to foster the understanding of, firstly, the mechanical behavior of the material itself and, secondly, the influence of cultivation parameters on cell seeded implants as well as on cell migration into acellular implants. In this study, acellular cartilage replacement material is theoretically, numerically and experimentally investigated regarding its viscoelastic properties, where a phenomenological model for practical applications is developed. Furthermore, remodeling and cell migration are investigated. (© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
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We show how to reduce the general formulation of the mass–angular momentum–charge inequality, for axisymmetric initial data of the Einstein–Maxwell equations, to the known maximal case whenever a geometrically motivated system of equations admits a solution. It is also shown that the same reduction argument applies to the basic inequality yielding a lower bound for the area of black holes in terms of mass, angular momentum, and charge. This extends previous work by the authors (Cha and Khuri, Ann Henri Poincaré, doi: 10.1007/s00023-014-0332-6, arXiv:1401.3384, 2014), in which the role of charge was omitted. Lastly, we improve upon the hypotheses required for the mass–angular momentum–charge inequality in the maximal case. 相似文献
68.
Virtual prototyping plays an ever increasing role in the engineering disciplines. Nowadays, engineers can rely on powerful tools like object oriented modeling languages, e.g., Modelica. Models written in this language can be simulated by open source software as well as commercial tools. The advantage of this approach is that the engineers can concentrate themselves on modeling, whereas the numerical intricacies of the simulation are handled by the software. On the other hand the simulations are usually slower than implementations which are parallelized and optimized manually. This can lead to computation times which are infeasible in practice, e.g., when a real time simulation is necessary for a hardware-in-the-loop simulation. In this contribution we are concerned with speeding up such automated simulations by parallelization (on desktop hardware as well as HPC systems). We examine the parallelism across the system approaches. Additionally, the influence of the problem formulation on the simulation time is discussed. The implemented methods are demonstrated on engineering examples. (© 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
69.
Machado Poliana A. L. Cavalcanti Marcello H. S. Silva Fábio A. B. de Almeida Eduardo T. Cardoso Marcus V. C. Mesquita Anderson F. Lemes Nelson H. T. Virtuoso Luciano S. 《Journal of solution chemistry》2022,51(3):320-344
Journal of Solution Chemistry - Liquid–liquid equilibrium (LLE) data and phase diagrams for new aqueous two-phase systems (ATPSs) containing 1-butyl-3-methylimidazolium chloride... 相似文献
70.
Sisi Huang Ray T. McClain Richard Kenneth Marcus 《Journal of separation science》2022,45(9):1502-1513
Reversed phase and size-exclusion chromatography methods are commonly used for protein separations, although they are based on distinctly different principles. Reversed phase methods yield hydrophobicity-based (loosely-termed) separation of proteins on porous supports, but tend to be limited to proteins with modest molecular weights based on mass transfer limitations. Alternatively, size-exclusion provides complementary benefits in the separation of higher mass proteins based on entropic, not enthalpic, processes, but tend to yield limited peak capacities. In this study, microbore columns packed with a novel trilobal polypropylene capillary-channeled polymer fiber were used in a reversed phase modality for the separation of polypeptides and proteins of molecular weights ranging from 1.4 to 660 kDa. Chromatographic parameters including gradient times, flow rates, and trifluoroacetic acid concentrations in the mobile phase were optimized to maximize resolution and throughput. Following optimization, the performance of the trilobal fiber column was compared to two commercial-sourced columns, a superficially porous C4-derivatized silica and size exclusion, both of which are sold specifically for protein separations and operated according to the manufacturer-specified conditions. In comparison to the commercial columns, the fiber-based column yielded better separation performance across the entirety of the suite, at much lower cost and shorter separation times. 相似文献